Effect of pH and Excipients on Structure, Dynamics, and Long-Term Stability of a Model IgG1 Monoclonal Antibody upon Freeze-Drying

2012 ◽  
Vol 30 (4) ◽  
pp. 968-984 ◽  
Author(s):  
Jihea Park ◽  
Karthik Nagapudi ◽  
Camille Vergara ◽  
Ranjini Ramachander ◽  
Jennifer S. Laurence ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Freeze Drying ◽  
Effect Of Ph ◽  
Term Stability ◽  
Long Term Stability ◽  
Structure Dynamics ◽  
Igg1 Monoclonal Antibody

PP-028 Long-term stability of diluted solutions of the monoclonal antibody infliximab

2015 ◽  
Vol 22 (Suppl 1) ◽  
pp. A127.3-A128
Author(s):  
I Suárez González ◽  
N Navas Iglesias ◽  
A Martínez Ortega ◽  
J Hernández Jiménez ◽  
A Salmerón García ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Term Stability ◽  
Long Term Stability

Genetic analyses of Per.C6 cell clones producing a therapeutic monoclonal antibody regarding productivity and long-term stability

2016 ◽  
Vol 100 (23) ◽  
pp. 10031-10041 ◽  
Author(s):  
Lilian Rumi Tsuruta ◽  
Mariana Lopes dos Santos ◽  
Fernanda Perez Yeda ◽  
Oswaldo Keith Okamoto ◽  
Ana Maria Moro
Keyword(s):  
Monoclonal Antibody ◽  
Genetic Analyses ◽  
Term Stability ◽  
Long Term Stability ◽  
Therapeutic Monoclonal Antibody ◽  
Cell Clones

PP-027 Long-term stability of solutions of the monoclonal antibody cetuximab

2015 ◽  
Vol 22 (Suppl 1) ◽  
pp. A127.2-A127
Author(s):  
I Suárez González ◽  
N Navas Iglesias ◽  
A Martínez Ortega ◽  
J Hernández Jiménez ◽  
A Salmerón García ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Stability Of Solutions ◽  
Term Stability ◽  
Long Term Stability

Long term stability of a HIV-1 neutralizing monoclonal antibody using isothermal calorimetry

2018 ◽  
Vol 554 ◽  
pp. 61-69 ◽  
Author(s):  
Benjamin R. Clarkson ◽  
Rajoshi Chaudhuri ◽  
Arne Schön ◽  
Jonathan W. Cooper ◽  
Lisa Kueltzo ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Isothermal Calorimetry ◽  
Term Stability ◽  
Long Term Stability ◽  
Neutralizing Monoclonal Antibody ◽  
Hiv 1

A Comparison of Spray-Drying and Freeze-Drying for the Production of Stable Silybin Nanosuspensions

2020 ◽  
Vol 20 (6) ◽  
pp. 3598-3603 ◽  
Author(s):  
Yingying Ma ◽  
Jin Gao ◽  
Wankui Jia ◽  
Yangyang Liu ◽  
Lanying Zhang ◽  
...  
Keyword(s):  
Spray Drying ◽  
Freeze Drying ◽  
Drying Methods ◽  
Dry Powders ◽  
Term Stability ◽  
Long Term Stability ◽  
Freeze Dried ◽  
Spray Dried

Spray-drying and freeze-drying are effective approaches to improve the long-term stability of nanosuspensions. This research explored the effect of spray-drying and freeze-drying techniques on PVP K30-stabilized silybin nanosuspensions. The morphology was observed by scanning electron microscopy (SEM): The spray-dried sample was spherical, and the freeze-dried samples were rodlike with smooth surfaces. The redispersibility was studied via dynamic light scattering (DLS): The size, PDI, and zeta of the spray-dried sample were 133.27 nm, 0.214, and 24.37 mV, respectively; the size, PDI, and zeta of the freeze-dried sample were 298.70 nm, 0.114, and 20.98 mV, respectively. The in vitro dissolution was studied, and the two dry powders showed a significant increase compared to silybin. The two dried powders had better long-term stability than the liquid starting material. Overall, spray-drying and freeze-drying are appropriate drying methods for the preparation of silybin nanosuspensions with better stability and dissolution velocity.

Freeze drying optimization of polymeric nanoparticles for ocular flurbiprofen delivery: effect of protectant agents and critical process parameters on long-term stability

2017 ◽  
Vol 43 (4) ◽  
pp. 637-651 ◽  
Author(s):  
Gladys Rosario Ramos Yacasi ◽  
Ana Cristina Calpena Campmany ◽  
María Antonia Egea Gras ◽  
Marta Espina García ◽  
María Luisa García López
Keyword(s):  
Process Parameters ◽  
Freeze Drying ◽  
Polymeric Nanoparticles ◽  
Term Stability ◽  
Long Term Stability ◽  
Critical Process Parameters ◽  
Critical Process
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