Health-related quality of life in Egyptian children with nephrotic syndrome

2020 ◽  
Vol 29 (8) ◽  
pp. 2185-2196
Author(s):  
Riham Eid ◽  
Aya Ahmed Fathy ◽  
Nashwa Hamdy
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Health Related Quality ◽  
Egyptian Children ◽  
Related Quality ◽  
Health Related

scholarly journals Reliability of generic quality-of-life instruments in assessing health-related quality of life among children and adolescents with idiopathic nephrotic syndrome: a systematic review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ann E. Aronu ◽  
Samuel N. Uwaezuoke ◽  
Uzoamaka V. Muoneke
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Children And Adolescents ◽  
Idiopathic Nephrotic Syndrome ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Generic Quality ◽  
Quality Of Life Instruments

Abstract Introduction Most of the studies reporting the negative impact of idiopathic nephrotic syndrome on health-related quality of life in children and adolescents were conducted with generic quality-of-life instruments rather than disease-specific instruments. The consistency of these studies' findings using these generic instruments is not well established. Aim This systematic review aims to determine the reliability of current generic quality-of-life instruments in assessing health-related quality of life among children and adolescents with idiopathic nephrotic syndrome. Methods We searched the PubMed, MEDLINE, EMBASE, and Google Scholar databases for articles published between 2000 and 2020, using appropriate descriptors. We included primary studies that met the eligibility criteria, independently screened their titles and abstracts, and removed all duplicates during the study-selection process. We resolved disagreements until a consensus was reached on study selection. We independently retrieved relevant data, including the generic quality-of-life instruments and the subjects’ and controls’ aggregate health-related quality of life scores, using a preconceived data-extraction form. Results Ten original articles were selected for qualitative and quantitative analyses. Some of the studies reported the following significant findings. The mean health-related quality of life scores for children with prevalent and incident nephrotic syndrome were 68.6 (range, 52.6–84.6) and 73.7 (range, 55.9–91.5), respectively. Children with idiopathic nephrotic syndrome and their controls with other chronic diseases had median scores of 65 (interquartile range, 59–68.75) and 62.2 (interquartile range, 58.05–65.78). Patients on oral immunosuppressive drug and intravenous rituximab reportedly had median scores of 76.2 and 72.6 and mean scores of 71.4 (range, 55.4–87.4) and 61.6 (range, 42.1–81.1) respectively for quality-of-life assessment on the ‘school functioning domain.’ Conclusions The health-related quality of life scores in patients with idiopathic nephrotic syndrome are consistently low. Lower scores occur in prolonged disease duration and severe clinical phenotypes, whereas the scores are higher than the scores obtained in other chronic diseases. These consistent findings underscore the reliability of the current generic instruments in assessing health-related quality of life in patients with idiopathic nephrotic syndrome.

scholarly journals SAT-316 HEALTH RELATED QUALITY OF LIFE OF CHILDREN WITH NEPHROTIC SYNDROME IN LAGOS NIGERIA

2019 ◽  
Vol 4 (7) ◽  
pp. S140 ◽  
Author(s):  
A. Solarin ◽  
M. Adekunle ◽  
H. Gbelee ◽  
A. Animashaun ◽  
F. Njokanma
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Health-Related Quality of Life Difference between Early Diagnosed and Finished Therapy of Nephrotic Syndrome in Children

2021 ◽  
Vol 9 (B) ◽  
pp. 801-805
Author(s):  
Riska Habriel Ruslie ◽  
Darmadi Darmadi ◽  
Cennikon Pakpahan
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Therapy Group ◽  
Steroid Resistance ◽  
Health Related Quality ◽  
Female Ratio ◽  
Related Quality ◽  
Health Related ◽  
The Difference

BACKGROUND: Nephrotic syndrome is the most common glomerular disease in children with high economic burden. The management of nephrotic syndrome at present is not only focusing in outcomes of disease but also the burden related to health-related quality of life (HRQOL). HRQOL of children with nephrotic syndrome is influenced by steroid dependence, steroid resistance, cytotoxic therapy, frequency of relapse, disease severity, socioeconomic status, and duration of illness. AIM: The objective of the study is to determine the difference of HRQOL in children between early diagnosed nephrotic syndrome and finished therapy of nephrotic syndrome. METHODS: A cross-sectional study was conducted between January and December 2018. Subjects were children aged 1–18 years with nephrotic syndrome and then divided into 2 groups based on either in the 1st week of full dose corticosteroid treatment or in the 1st week after finishing therapy equally. Demographical data, nutritional status, and laboratory results were obtained. HRQOL was measured using PedsQL 4.0 questionnaire in the Indonesian language. The difference of HRQOL was analyzed using independent T-test. RESULTS: A total of 100 subjects enrolled in this study and divided into two groups. Male-to-female ratio was 4:1 in early diagnosed group and 7.3:1 in finished therapy group. Mean age of subjects for the early diagnosed group was 4.6 years and finished therapy group was 5.3 years. Total HRQOL was improved after treatment administration in children with nephrotic syndrome (p < 0.001). The improvement was most significant in physical domain (p = 0.002). CONCLUSION: HRQOL in children with early diagnosed nephrotic syndrome was lower compared to children with finished therapy of nephrotic syndrome.

scholarly journals Prevalence of Functional Gastrointestinal Disorders among School-aged Children and adolescents, A Multicenter Study

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A T A Ibrahim ◽  
A M Hamdy ◽  
M A Elhodhod
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Arabic Translation ◽  
Income Per Capita ◽  
School Aged Children ◽  
Egyptian Children ◽  
Related Quality ◽  
Health Related ◽  
Per Capita

Abstract Background The term Functional Gastrointestinal Disorder ‘(FGID)’ defines several and variable combinations of recurrent or chronic gastrointestinal (GI) symptoms that do not have an identified underlying pathophysiology. Without an objective marker, the classification of FGIDs depends on symptoms. The aim of the Work: To measure the prevalence of FGIDs among a representative sample of school-aged children/adolescents aging 4-18 years, to determine the socio-demographic characteristics of children affected by FGID and to assess the effect of FGIDs on health-related quality of life concerning both the child and the parent/caregiver. Patients and Methods The present cross-sectional study included 1082 Egyptian children/adolescents with age varying between 4-18 yrs. They were randomly selected among those attending primary, preparatory and secondary schools at Cairo, El-Gharbya and El-Sharqia governorates in the period from September 2017 to September 2018. Each child was subjected to clinical history taking, assessment of socioeconomic standard of family, assessment for presence of FGIDs using an Arabic translation of “Rome 4 diagnostic Questionnaire for pediatric functional GI disorders” and using Arabic translation of HRQOL score which included social and school functioning to study the effect of FGIDs on quality of life of children and parents. Results Mean age for screened children was 8.05 ± 3.03 years. 574 (53.1%) were males. The prevalence of FGIDs among studied children was 30.4%. Irritable bowel syndrome (IBS) was the most common type of FGIDs (11.6%), followed by functional constipation (8.4%), then functional dyspepsia (4.6%). Late order of birth and more members in the family, lower income per capita were all significantly related to positive FGID diagnosis. Children with FGID had lower scores for health-related quality of life (HRQOL). Conclusion FGIDs are common in school-aged Egyptian children/adolescents; IBS is the most common. Risk factors associated with having FGID include increased family members and decreased income per capita. FGIDs adversely affect the HRQOL of patients.

scholarly journals Health-related quality of life in a group of Egyptian children and adolescents with type 1 diabetes: relationship to microvascular complications

2019 ◽  
Vol 43 (1) ◽  
Author(s):  
Zeinab Mohammed Monir ◽  
Mona Hussein El Samahy ◽  
Ehab Mohammed Eid ◽  
Abla Galal Khalifa ◽  
Soheir abd-El Mawgood abd-ElMaksoud ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Microvascular Complications ◽  
Health Related Quality ◽  
Egyptian Children ◽  
Related Quality ◽  
Health Related

scholarly journals Impact of the COVID-19 Pandemic on Health-Related Quality of Life and Anxiety in Pediatric Hematology/Oncology Patients: A Single Egyptian Center Experience

2020 ◽  
Author(s):  
Eman Hassan ◽  
Dalia Nagui Rizk ◽  
Nourhan Moustafa Aly ◽  
Yasmine El Chazli
Keyword(s):  
Quality Of Life ◽  
World Health ◽  
Health Related Quality ◽  
Oncology Patients ◽  
Pediatric Hematology ◽  
Egyptian Children ◽  
Related Quality ◽  
Health Related ◽  
Anxiety Levels

Abstract Background: Since the World Health Organization declared coronavirus disease 2019 (COVID-19) pandemic on March 11, 2020, the tremendous strain on ill-prepared healthcare services affected the management of patients suffering from various comorbidities and added to the psychological burden. The study aimed to assess the health-related quality of life (HRQoL) of pediatric Hematology/Oncology patients during the COVID-19 pandemic as a reflection of the quality of health care services and to assess anxiety levels and its impact on HRQoL. Methods: a cross-sectional study of 292 Egyptian children between 2.5 - 13 years with chronic hematological/oncological disorders categorized as bleeding/coagulation disorders, transfusion-dependent patients, and patients receiving chemotherapy. Validated Arabic versions of Pediatric Quality of Life Inventory 4.0 Generic Core Scale and Spence Children's Anxiety Scale were used for assessment of HRQoL and anxiety, respectively. Results: the mean age was 8.72 ± 3.66 years, 52.4% were males and 65.4% were transfusion-dependent patients. Almost 60% of children were aware of the pandemic and 60.3% had blood transfusion difficulties. Males had significantly lower anxiety levels than females (p < 0.001), and transfusion-dependent patients also had significantly lower anxiety levels than patients receiving chemotherapy (p < 0.001). Children who were aware of the COVID-19 pandemic had lower anxiety levels than those who were not (p = 0.006), while those suffering from fewer clinic days had higher anxiety levels (p = 0.02). Several factors have been shown to affect the HRQoL in the three patients’ categories and anxiety significantly reduced the three HRQoL domains (p < 0.001). The overall emotional functioning score was better than the physical and social aspects. Conclusion: This study highlights the effect of the COVID-19 pandemic on the anxiety level and hence the HRQoL of chronic hematological/oncological pediatric patients as a crucial step in guiding policies and interventions to maintain their psychological wellbeing.

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