scholarly journals Health-Related Quality of Life Difference between Early Diagnosed and Finished Therapy of Nephrotic Syndrome in Children

2021 ◽  
Vol 9 (B) ◽  
pp. 801-805
Author(s):  
Riska Habriel Ruslie ◽  
Darmadi Darmadi ◽  
Cennikon Pakpahan
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Therapy Group ◽  
Steroid Resistance ◽  
Health Related Quality ◽  
Female Ratio ◽  
Related Quality ◽  
Health Related ◽  
The Difference

BACKGROUND: Nephrotic syndrome is the most common glomerular disease in children with high economic burden. The management of nephrotic syndrome at present is not only focusing in outcomes of disease but also the burden related to health-related quality of life (HRQOL). HRQOL of children with nephrotic syndrome is influenced by steroid dependence, steroid resistance, cytotoxic therapy, frequency of relapse, disease severity, socioeconomic status, and duration of illness. AIM: The objective of the study is to determine the difference of HRQOL in children between early diagnosed nephrotic syndrome and finished therapy of nephrotic syndrome. METHODS: A cross-sectional study was conducted between January and December 2018. Subjects were children aged 1–18 years with nephrotic syndrome and then divided into 2 groups based on either in the 1st week of full dose corticosteroid treatment or in the 1st week after finishing therapy equally. Demographical data, nutritional status, and laboratory results were obtained. HRQOL was measured using PedsQL 4.0 questionnaire in the Indonesian language. The difference of HRQOL was analyzed using independent T-test. RESULTS: A total of 100 subjects enrolled in this study and divided into two groups. Male-to-female ratio was 4:1 in early diagnosed group and 7.3:1 in finished therapy group. Mean age of subjects for the early diagnosed group was 4.6 years and finished therapy group was 5.3 years. Total HRQOL was improved after treatment administration in children with nephrotic syndrome (p < 0.001). The improvement was most significant in physical domain (p = 0.002). CONCLUSION: HRQOL in children with early diagnosed nephrotic syndrome was lower compared to children with finished therapy of nephrotic syndrome.

scholarly journals Reliability of generic quality-of-life instruments in assessing health-related quality of life among children and adolescents with idiopathic nephrotic syndrome: a systematic review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ann E. Aronu ◽  
Samuel N. Uwaezuoke ◽  
Uzoamaka V. Muoneke
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Children And Adolescents ◽  
Idiopathic Nephrotic Syndrome ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Generic Quality ◽  
Quality Of Life Instruments

Abstract Introduction Most of the studies reporting the negative impact of idiopathic nephrotic syndrome on health-related quality of life in children and adolescents were conducted with generic quality-of-life instruments rather than disease-specific instruments. The consistency of these studies' findings using these generic instruments is not well established. Aim This systematic review aims to determine the reliability of current generic quality-of-life instruments in assessing health-related quality of life among children and adolescents with idiopathic nephrotic syndrome. Methods We searched the PubMed, MEDLINE, EMBASE, and Google Scholar databases for articles published between 2000 and 2020, using appropriate descriptors. We included primary studies that met the eligibility criteria, independently screened their titles and abstracts, and removed all duplicates during the study-selection process. We resolved disagreements until a consensus was reached on study selection. We independently retrieved relevant data, including the generic quality-of-life instruments and the subjects’ and controls’ aggregate health-related quality of life scores, using a preconceived data-extraction form. Results Ten original articles were selected for qualitative and quantitative analyses. Some of the studies reported the following significant findings. The mean health-related quality of life scores for children with prevalent and incident nephrotic syndrome were 68.6 (range, 52.6–84.6) and 73.7 (range, 55.9–91.5), respectively. Children with idiopathic nephrotic syndrome and their controls with other chronic diseases had median scores of 65 (interquartile range, 59–68.75) and 62.2 (interquartile range, 58.05–65.78). Patients on oral immunosuppressive drug and intravenous rituximab reportedly had median scores of 76.2 and 72.6 and mean scores of 71.4 (range, 55.4–87.4) and 61.6 (range, 42.1–81.1) respectively for quality-of-life assessment on the ‘school functioning domain.’ Conclusions The health-related quality of life scores in patients with idiopathic nephrotic syndrome are consistently low. Lower scores occur in prolonged disease duration and severe clinical phenotypes, whereas the scores are higher than the scores obtained in other chronic diseases. These consistent findings underscore the reliability of the current generic instruments in assessing health-related quality of life in patients with idiopathic nephrotic syndrome.

scholarly journals SAT-316 HEALTH RELATED QUALITY OF LIFE OF CHILDREN WITH NEPHROTIC SYNDROME IN LAGOS NIGERIA

2019 ◽  
Vol 4 (7) ◽  
pp. S140 ◽  
Author(s):  
A. Solarin ◽  
M. Adekunle ◽  
H. Gbelee ◽  
A. Animashaun ◽  
F. Njokanma
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Adolescent-parent disagreement on health-related quality of life in food allergic adolescents; who makes the difference?

2011 ◽  
Vol 1 (S1) ◽  
Author(s):  
Jantina L van der Velde ◽  
Bertine MJ Flokstra-de Blok ◽  
Ann Hamp ◽  
Rebecca C Knibb ◽  
Eric J Duiverman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Adolescent Parent ◽  
The Difference

scholarly journals Social gradient in health-related quality of life among urban residents in Limassol, Cyprus: Research article

2020 ◽  
Author(s):  
Panagiota Ellina ◽  
Nicos Middleton ◽  
Ekaterini Lambrinou ◽  
Christiana Kouta
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Social Inequalities ◽  
Social Gradient ◽  
Health Related Quality ◽  
Social Inequalities In Health ◽  
Related Quality ◽  
Health Related ◽  
The Difference

Abstract Background: Social inequalities in health threaten social cohesion and, therefore, their investigation is an important research field. Monitoring the health of the population is necessary to identify health needs, design programs focused in people’s needs and to evaluate the effectiveness of health policies.Methods: A cross-sectional survey using primary data was applied. The study investigates the size and the extent of social inequalities in quality of life and health behaviours in Limassol, Cyprus. Data collection was done by door-to-door survey, in the form of interviews. The sample consisted of 450 residents aged 45-64 across 45 randomly selected neighbourhoods, that met the selection criteria. The tools used were: Demographic questionnaire, SF 36 Questionnaire, IPAQ- International Physical Activity Questionnaire short form.Results: The social gradient appears in all social indicators. As for the physical dimension of health has a strong relationship between health-related quality of life with the education index. Specifically, the difference between the two poles is 12 points for men and 14 points for women (p = 0.16). Profession systematically appears to have a stronger relationship with men than with women, and is present in both physical and mental dimensions. Specifically, the difference between the two poles is 13 points for men and 10 points for women (p = 0.31).Conclusions: Exploring social inequalities in health-related quality of life, is a complex situation influencing social, physical and psychological health state. It seems that young male individuals, who are highly educated, employed full time, earning high incomes and engaging in mild physical activity, have significantly higher level of health-related life quality, compared to other middle age adult groups, living in Limassol. This finding is in agreement with other studies that show correlations between gender and the patterns of risk factors.

scholarly journals Social gradient in health-related quality of life among urban residents in Limassol, Cyprus: Research article

2020 ◽  
Author(s):  
Panagiota Ellina ◽  
Nicos Middleton ◽  
Ekaterini Lambrinou ◽  
Christiana Kouta
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Social Inequalities ◽  
Social Gradient ◽  
Health Related Quality ◽  
Social Inequalities In Health ◽  
Related Quality ◽  
Health Related ◽  
The Difference

Abstract Background: Social inequalities in health threaten social cohesion and, therefore, their investigation is an important research field. Monitoring the health of the population is necessary to identify health needs, design programs focused in people’s needs and to evaluate the effectiveness of health policies.Methods: A cross-sectional survey using primary data was applied. The study investigates the size and the extent of social inequalities in quality of life and health behaviours in Limassol, Cyprus. Data collection was done by door-to-door survey, in the form of interviews. The sample consisted of 450 residents aged 45-64 across 45 randomly selected neighbourhoods, that met the selection criteria. The tools used were: Demographic questionnaire, SF 36 Questionnaire, IPAQ- International Physical Activity Questionnaire short form.Results: The social gradient appears in all social indicators. As for the physical dimension of health has a strong relationship between health-related quality of life with the education index. Specifically, the difference between the two poles is 12 points for men and 14 points for women (p = 0.16). Profession systematically appears to have a stronger relationship with men than with women, and is present in both physical and mental dimensions. Specifically, the difference between the two poles is 13 points for men and 10 points for women (p = 0.31).Conclusions: Exploring social inequalities in health-related quality of life, is a complex situation influencing social, physical and psychological health state. It seems that young male individuals, who are highly educated, employed full time, earning high incomes and engaging in mild physical activity, have significantly higher level of health-related life quality, compared to other middle age adult groups, living in Limassol. This finding is in agreement with other studies that show correlations between gender and the patterns of risk factors.

scholarly journals A questionnaire for rating health-related quality of life

2021 ◽  
Vol 60 (4) ◽  
pp. 260-268
Author(s):  
Slobodan M. Janković ◽  
Nataša Bogavac-Stanojević ◽  
Iva Mikulić ◽  
Sebija Izetbegović ◽  
Ivana Iličković ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Convergent Validity ◽  
Health Related Quality ◽  
Good Reliability ◽  
Cross Sectional ◽  
Female Ratio ◽  
Related Quality ◽  
Health Related ◽  
Hrqol Scale

Abstract Background Translations of instruments for measuring quality of life developed in certain, mostly more developed, parts of the world usually do not cover regionally specific aspects of health-related quality of life, even after transcultural validation. The aim of this study was to develop and validate a reliable questionnaire in Serbian, Croatian, Bosnian, and Montenegrin languages suitable for measuring health-related quality of life in adults. Methods The study was of a cross-sectional type, assessing the reliability and validity of a newly developed questionnaire for measuring health-related quality of life (HRQoL) in adults residing in western Balkan states (WB-HRQoL). It was conducted on a sample of 489 adults from Serbia, Croatia, Bosnia & Herzegovina, and Montenegro, with a mean age of 52.2±14.4 years and a male/female ratio of 195/294 (39.9%/60.1%). Result The definitive version of the WB-HRQoL scale with 19 items showed very good reliability, with Cronbach’s alpha 0.905. The scale was temporally stable, and satisfactory results were obtained for divergent and convergent validity tests. Exploratory factorial analysis brought to the surface four domains of health-related quality of life, namely the physical, psychical, social, and environmental. Conclusion The WB-HRQoL scale is a reliable and valid generic instrument for measuring HRQoL that takes into account the cultural specifics of the western Balkan region.

scholarly journals Evaluation of differences in health-related quality of life in patients receiving conventional versus newer anti-epileptic drugs

2020 ◽  
Vol 9 (2) ◽  
pp. 342
Author(s):  
Kavisha S. Goswami ◽  
Devang A. Rana ◽  
Shalin Shah ◽  
Supriya D. Malhotra
Keyword(s):  
Quality Of Life ◽  
Single Point ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Male Predominance ◽  
Related Quality ◽  
Health Related ◽  
The Difference ◽  
Better Than

Background: Epilepsy is associated with stigma and bad health-related quality of life (HR-QOL) due to this, and side effects of the drug therapy. Newer anti-epileptics are claimed to be better than the conventional. We evaluated this based on comparison of HR-QOL in patients taking the respective therapy.Methods: An observational, cross-sectional, single point study involved 127 consenting patients from Neurology OPD at V.S. General Hospital. Quality of life in epilepsy-10 (QOLIE-10) questionnaire was used to measure HR-QOL in patients. SPSS software and Graphpad prism were used to analyze the variables.Results: Patients of 20-30 age group were commonly affected (37.80%) with a male predominance (56.69%). 41.73% were unemployed. The difference in HR-QOL between patients and controls in all three domains (epilepsy effects, mental effects, role function domains) of QOLIE-10 was significant (p=0.0002), indicating better HR-QOL in controls. The worst HR-QOL scores were found in Epilepsy effects domain. Metabolic adverse effects (38.58%) were the common ADRs. Sodium valproate was the most effective in controlling seizures (last seizure episode: 15 months). HR-QOL correlation between patients receiving monotherapy and polytherapy was significant (p=0.026) with monotherapy rendering a better HR-QOL. Comparison of HR-QOL between patients taking the conventional and the newer drugs was not significant (p=0.1768).Conclusions: Our study nullifies the claims that newer drugs are better than the conventional since no such benefit was seen in HR-QOL as well as ADRs. Our findings ruled out the belief that cases of epilepsy are better controlled with polytherapy.

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