Platelet–lymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome

2014 ◽  
Vol 39 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Handan Inonu Koseoglu ◽  
Fatih Altunkas ◽  
Asiye Kanbay ◽  
Sibel Doruk ◽  
Ilker Etikan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Independent Predictor ◽  
Sleep Apnea Syndrome ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Cardiovascular outcomes of CPAP therapy in obstructive sleep apnea syndrome

2007 ◽  
Vol 293 (4) ◽  
pp. R1666-R1670 ◽  
Author(s):  
Walter T. McNicholas
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Cpap Therapy ◽  
Obstructive Sleep ◽  
Cardiovascular Morbidity And Mortality ◽  
Apnea Syndrome ◽  
The Impact

Considerable evidence is now available of an independent association between obstructive sleep apnea syndrome (OSAS) and cardiovascular disease. The association is particularly strong for systemic arterial hypertension, but there is growing evidence of an association with ischemic heart disease and stroke. The mechanisms underlying cardiovascular disease in patients with OSAS are still poorly understood. However, the pathogenesis is likely to be a multifactorial process involving a diverse range of mechanisms, including sympathetic overactivity, selective activation of inflammatory molecular pathways, endothelial dysfunction, abnormal coagulation, and metabolic dysregulation, the latter particularly involving insulin resistance and disordered lipid metabolism. Therapy with continuous positive airway pressure (CPAP) has been associated with significant benefits to cardiovascular morbidity and mortality, both in short-term studies addressing specific aspects of morbidity, such as hypertension, and more recently in long-term studies that have evaluated major outcomes of cardiovascular morbidity and mortality. However, there is a clear need for further studies evaluating the impact of CPAP therapy on cardiovascular outcomes. Furthermore, studies on the impact of CPAP therapy have provided useful information concerning the role of basic cell and molecular mechanisms in the pathophysiology of OSAS.

scholarly journals Predictive factors facilitate identification of potential aortic dissection in patients with obstructive sleep apnea syndrome

2021 ◽  
Author(s):  
dinghui wu ◽  
Dandan Jiang ◽  
Qu Chen ◽  
xiangyang yao ◽  
chunping dong ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Aortic Dissection ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Sleep Study ◽  
Hypertensive Patients ◽  
Lymphocyte Ratio ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Objective: Investigating potential predictors of aortic dissection development in high-risk hypertensive patients with obstructive sleep apnea syndrome (OSAS). Methods: Hypertensive patients with aortic dissection, admitted to hospital between January 2010 and July 2020, was diagnosed with OSAS by overnight sleep study with polysomnography (PSG). Results: Male was liable to aortic dissection compared to female in both groups（84.7% and 86% respectively）.There were actually significant differences with regard to neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV) / platelet count (PLT) ratio and D-dimer that we concerned about and were of great value in aortic dissection as previously reported. As multivariable regression analysis revealed, NLR (odds rate [OR], 2.258, 95% confidence interval [CI], 1.464-3.482, P<0.05), MPV/PLT (OR, 2.743, 95%CI, 1.713-4.392, P<0.05) and apnea and hypopnea index (AHI) (OR, 1.746,95% CI, 1.225-1.320, P<0.05) were all independent risk factors for aortic dissection. receiver operating characteristic curves analysis of NLR, MPV/PLT, AHI and combination of indicators for aortic dissection revealed combination of NLR, MPV/PLT ratio and AHI is of outstanding predictive value with sensitivity of 0.904 and specificity of 0.847. At the thresholds of 4.41 for NLR and 5.14 for MPV/PLT and 35.95 for AHI, 87.5% of all studied patients were expected to be correctly diagnosed with regard to aortic dissection. Conclusion: Inflammation, platelet alteration is crucial for initiation and progression of aortic dissection. Combined detection of NLR, MPV/PLT ratio and AHI could assist sleep physicians to identify silent or potential aortic dissection in patient comorbidity OSAS and hypertension.

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