scholarly journals The Significance of the Relative Lymphocyte Count as an Independent Predictor of Cardiovascular Disease in Patients with Obstructive Sleep Apnea Syndrome

2016 ◽  
Vol 25 (5) ◽  
pp. 455-460 ◽  
Author(s):  
Vildan Altunayoglu Cakmak ◽  
Savas Ozsu ◽  
Ayhan Gulsoy ◽  
Ramazan Akpinar ◽  
Yilmaz Bulbul
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Lymphocyte Count ◽  
Independent Predictor ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Platelet–lymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome

2014 ◽  
Vol 39 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Handan Inonu Koseoglu ◽  
Fatih Altunkas ◽  
Asiye Kanbay ◽  
Sibel Doruk ◽  
Ilker Etikan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Independent Predictor ◽  
Sleep Apnea Syndrome ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Cardiovascular outcomes of CPAP therapy in obstructive sleep apnea syndrome

2007 ◽  
Vol 293 (4) ◽  
pp. R1666-R1670 ◽  
Author(s):  
Walter T. McNicholas
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Cpap Therapy ◽  
Obstructive Sleep ◽  
Cardiovascular Morbidity And Mortality ◽  
Apnea Syndrome ◽  
The Impact

Considerable evidence is now available of an independent association between obstructive sleep apnea syndrome (OSAS) and cardiovascular disease. The association is particularly strong for systemic arterial hypertension, but there is growing evidence of an association with ischemic heart disease and stroke. The mechanisms underlying cardiovascular disease in patients with OSAS are still poorly understood. However, the pathogenesis is likely to be a multifactorial process involving a diverse range of mechanisms, including sympathetic overactivity, selective activation of inflammatory molecular pathways, endothelial dysfunction, abnormal coagulation, and metabolic dysregulation, the latter particularly involving insulin resistance and disordered lipid metabolism. Therapy with continuous positive airway pressure (CPAP) has been associated with significant benefits to cardiovascular morbidity and mortality, both in short-term studies addressing specific aspects of morbidity, such as hypertension, and more recently in long-term studies that have evaluated major outcomes of cardiovascular morbidity and mortality. However, there is a clear need for further studies evaluating the impact of CPAP therapy on cardiovascular outcomes. Furthermore, studies on the impact of CPAP therapy have provided useful information concerning the role of basic cell and molecular mechanisms in the pathophysiology of OSAS.

scholarly journals Serum gamma-glutamyl transferase activity is an independent predictor for cardiovascular disease in Obstructive Sleep Apnea Syndrome

2011 ◽  
Vol 105 (4) ◽  
pp. 637-642 ◽  
Author(s):  
Asiye Kanbay ◽  
Elif Kaya ◽  
Hakan Buyukoglan ◽  
Nezihe Ozdogan ◽  
Mehmet Gungor Kaya ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Independent Predictor ◽  
Sleep Apnea Syndrome ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Glutamyl Transferase

scholarly journals The rheological properties of blood and the risk of cardiovascular disease in patients with obstructive sleep apnea syndrome (OSAS)

2011 ◽  
Vol 49 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Maciej Tażbirek ◽  
Ludmiła Słowińska ◽  
Marcin Kawalski ◽  
Władysław Pierzchała
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Rheological Properties ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Serum levels of γ-glutamyl transferase are associated with cardiovascular disease in obstructive sleep apnea syndrome

2013 ◽  
Vol 33 (6) ◽  
pp. 584-590 ◽  
Author(s):  
Handan Inonu Koseoglu ◽  
Fatih Altunkas ◽  
Osman Demir ◽  
Sibel Doruk ◽  
Ilker Etikan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Serum Levels ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Glutamyl Transferase

scholarly journals Pathophysiologic Mechanisms of Cardiovascular Disease in Obstructive Sleep Apnea Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
Carlos Zamarrón ◽  
Luis Valdés Cuadrado ◽  
Rodolfo Álvarez-Sala
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Metabolic Effects ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep disorder, characterized by repeated disruptions of breathing during sleep. This disease has many potential consequences including excessive daytime sleepiness, neurocognitive deterioration, endocrinologic and metabolic effects, and decreased quality of life. Patients with OSAS experience repetitive episodes of hypoxia and reoxygenation during transient cessation of breathing that provoke systemic effects. Furthermore, there may be increased levels of biomarkers linked to endocrine-metabolic and cardiovascular alterations. Epidemiological studies have identified OSAS as an independent comorbid factor in cardiovascular and cerebrovascular diseases, and physiopathological links may exist with onset and progression of heart failure. In addition, OSAS is associated with other disorders and comorbidities which worsen cardiovascular consequences, such as obesity, diabetes, and metabolic syndrome. Metabolic syndrome is an emerging public health problem that represents a constellation of cardiovascular risk factors. Both OSAS and metabolic syndrome may exert negative synergistic effects on the cardiovascular system through multiple mechanisms (e.g., hypoxemia, sleep disruption, activation of the sympathetic nervous system, and inflammatory activation). It has been found that CPAP therapy for OSAS provides an objective improvement in symptoms and cardiac function, decreases cardiovascular risk, improves insulin sensitivity, and normalises biomarkers. OSAS contributes to the pathogenesis of cardiovascular disease independently and by interaction with comorbidities. The present review focuses on indirect and direct evidence regarding mechanisms implicated in cardiovascular disease among OSAS patients.

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