Vascular calcification score on plain radiographs of the feet as a predictor of peripheral arterial disease in patients with chronic kidney disease

2009 ◽  
Vol 42 (3) ◽  
pp. 773-780 ◽  
Author(s):  
Won Suk An ◽  
Young Ki Son ◽  
Seong-Eun Kim ◽  
Ki-Hyun Kim ◽  
Seong Kuk Yoon ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Vascular Calcification ◽  
Arterial Disease ◽  
Plain Radiographs ◽  
Calcification Score ◽  
Peripheral Arterial

Abstract 20579: Chronic Kidney Disease is Associated With Increased Mortality and Major Adverse Cardiovascular Events in Patients With Peripheral Arterial Disease

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Gregory G Westin ◽  
Ehrin J Armstrong ◽  
Debbie C Chen ◽  
John R Laird
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Cardiovascular Events ◽  
Cox Model ◽  
Univariate Analysis ◽  
Arterial Disease ◽  
Major Adverse Cardiovascular Events ◽  
Ckd Stage ◽  
Peripheral Arterial

Introduction: Chronic kidney disease (CKD) is common in patients with peripheral arterial disease (PAD), but patients with severe CKD have been excluded from many trials and no objective performance goals exist for patients with PAD and CKD. We sought to analyze the association between severity of CKD and cardiovascular and limb-related outcomes among patients with PAD. Methods: We reviewed records of all patients at our institution who underwent lower extremity angiography between 2006 and 2013. We analyzed outcomes including mortality, major adverse cardiovascular event (MACE) rate, and major adverse limb event (MALE) rate according to clinical stage of CKD, determined by calculating each patient’s glomerular filtration rate using the Cockcroft-Gault equation. We used Cox proportional hazard modeling to account for covariates, along with Bonferroni correction for multiple comparisons. Results: Of 773 patients, 45% had CKD stage 3-5. The patients had a median age of 67, were 58% male, 51% diabetic, and 57% presented with critical limb ischemia (CLI). During a median follow-up time of 3.2 years, patients with higher stages of CKD had an increased rate of death (Figure 1, p<0.001). CKD stages 4 and 5 were significant predictors of mortality in a multivariate model (HR 3.2 and 2.4 vs. CKD 1, P<0.001 and P<0.01, respectively). An analysis of MACE by CKD stage demonstrated similar results (CKD 4 HR 2.2, p<0.01; CKD 5 HR 2.0, p<0.01). CKD stage also predicted MALE in a univariate analysis (p<0.01), driven by increased limb events among patients with CKD stage 5 (p<0.01). However, CKD stage did not demonstrate a significantly increased hazard of MALE in a multivariate Cox model. Conclusions: Patients with PAD who also have CKD have increased rates of adverse outcomes. This relationship seems to be more robust for major cardiovascular events and overall mortality than for major limb events. Future studies should investigate how management of PAD should differ for patients with CKD.

scholarly journals Subclinical peripheral arterial disease in patients with chronic kidney disease: Prevalence and related risk factors

2005 ◽  
Vol 67 ◽  
pp. S44-S47 ◽  
Author(s):  
Soledad Garcia de Vinuesa ◽  
Mayra Ortega ◽  
Patricia Martinez ◽  
Marian Goicoechea ◽  
Francisco Gomez Campdera ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Disease Prevalence ◽  
Chronic Kidney Disease Prevalence ◽  
Related Risk ◽  
Peripheral Arterial

scholarly journals MO762RELATIONSHIP BETWEEN INFLAMMATION AND PERIPHERAL ARTERIAL DISEASE MEASURED BY ANKLE-BRACHIAL INDEX IN CHRONIC HEMODIALYSIS PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Yanet Parodis ◽  
Tania Monzon ◽  
Francisco Valga ◽  
Gloria Anton-Perez
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Point Group ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Chronic Hemodialysis ◽  
Lymphocyte Ratio ◽  
Markers Of Inflammation ◽  
Peripheral Arterial

Abstract Background and Aims Peripheral arterial disease (PAD) is very common in patients with chronic kidney disease. There are predisposing factors such as high blood pressure, diabetes mellitus, and dyslipidemia that are highly prevalent in this population. The ankle-brachial index (ABI) is a widely validated diagnostic method for the diagnosis of PAD. A value below 0.9 is suggestive of this pathology. On the other hand, inflammation is a phenomenon that favors development of atherosclerosis and therefore could be another predisposing factor for PAD. There are emerging markers of inflammation such as the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) that have an excellent correlation with classic markers such as C-reactive protein (CRP). The objective of our study was to determine whether there is a relationship between ABI values and the degree of inflammation in patients. Method A retrospective observational cross-sectional study was conducted in our prevalent hemodialysis population between April-May 2019. ABI was measured through the Microlife WatchBP Office ABI™ device. The sample was divided into two groups using 0.9 as a cut-off point: group 1 (ABI &lt;0.9) and group 2 (ABI&gt; 0.9). Inflammatory ratios (NLR, PLR and SII) and other parameters of bone kidney disease such as serum calcium, bicarbonate, phosphorus, parathyroid hormone (PTH), magnesium and vitamin D were determined. Results 100 patients with chronic kidney disease on chronic hemodialysis belonging to our Avericum Negrin center were analyzed. 42% (N = 42) of the sample were women and 42% (N = 42) were diabetic. The etiology of kidney disease was: 12% (N = 12) renal nephroangiosclerosis, 35% (N = 35) diabetic nephropathy, 14% (N = 14) chronic glomerulonephritis, 8% (N = 8) polycystic kidney disease, 17% (N = 17) unknow and 14% (N = 14) others. 19% (N = 19) had a central venous catheter as vascular access. The mean values of inflammatory and renal bone disease parameters are described in Table 1. The values of PLR and SII index were significantly higher in patients with ABI &lt;0.9. (Figures 1 and 2). Conclusion Patients with peripheral arterial disease (ABI &lt;0.9) had higher PLR and SII values

scholarly journals Risk Factors for Peripheral Arterial Disease Among Patients With Chronic Kidney Disease

2012 ◽  
Vol 110 (1) ◽  
pp. 136-141 ◽  
Author(s):  
Jing Chen ◽  
Emile R. Mohler ◽  
Dawei Xie ◽  
Michael G. Shlipak ◽  
Raymond R. Townsend ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Contrast-induced nephropathy in patients with chronic kidney disease and peripheral arterial disease

2015 ◽  
Vol 4 (6) ◽  
pp. 205846011558303 ◽  
Author(s):  
Christian Kroneberger ◽  
Christian N Enzweiler ◽  
Andre Schmidt-Lucke ◽  
Ralph-Ingo Rückert ◽  
Ulf Teichgräber ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Serum Creatinine ◽  
Contrast Material ◽  
Arterial Disease ◽  
Contrast Induced Nephropathy ◽  
Related Risk ◽  
Peripheral Arterial

Background The risk for contrast-induced nephropathy (CIN) after intra-arterial application of an iodine-based contrast material is unknown for patients with chronic kidney disease (CKD) and peripheral arterial disease (PAD). Purpose To investigate the incidence of CIN in patients with CKD and PAD. Material and Methods This retrospective study was approved by the local ethics committee. One hundred and twenty patients with 128 procedures (73 with baseline eGFR in the range of 45–60 mL/min/1.73m2, 55 with eGFR < 45 mL/min/1.73m2) were evaluated. All patients received intra-arterially an iodine-based low-osmolar contrast material (CM) after adequate intravenous hydration with isotonic NaCl 0.9% solution. CIN was defined as an increase in serum creatinine of more than 44 μmol/L within 4 days. The influence of patient-related risk factors (age, weight, body mass index, eGFR, serum creatinine, hypertension, diabetes mellitus, coronary heart disease, heart failure) and therapy-related risk factors (amount of CM, nephrotoxic drugs, number of CM applications) on CIN were examined. Results CIN developed in 0% (0/73) of procedures in patients with PAD and an eGFR in the range of 45–60 mL/min/1.73m2 and in 10.9% (6/55) of procedures in patients with an eGFR <45 mL/min/1.73m2. No risk factor significantly influenced the development of CIN, although baseline serum creatinine ( P = 0.06) and baseline eGFR ( P = 0.10) showed a considerable dependency. Conclusion Patients with an eGFR in the range of 45–60 mL/min/1.73m2 and PAD seem not at risk for CIN after intra-arterial CM application and adequate hydration. Whereas, an eGFR < 45 mL/min/1.73m2 correlated with a risk of 10.9% for a CIN.

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