scholarly journals Minimal-invasive management of urological complications after kidney transplantation

2021 ◽  
Author(s):  
Susanne Deininger ◽  
Silvio Nadalin ◽  
Bastian Amend ◽  
Martina Guthoff ◽  
Nils Heyne ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Postoperative Morbidity ◽  
Minimal Invasive ◽  
Endoscopic Management ◽  
Allograft Survival ◽  
Urological Complications ◽  
Allograft Function ◽  
Stage Renal Disease ◽  
End Stage ◽  
Invasive Management

AbstractKidney transplantation represents the gold standard treatment option for patients with end-stage renal disease. Improvements in surgical technique and pharmacologic treatment have continuously prolonged allograft survival in recent years. However, urological complications are frequently observed, leading to both postoperative morbidity and putative deterioration of allograft function. While open redo surgery in these patients is often accompanied by elevated surgical risk, endoscopic management of urological complications is an alternative, minimal-invasive option. In the present article, we reviewed the literature on relevant urological postoperative complications after kidney transplantation and describe preventive approaches during the pre-transplantation assessment and their management using minimal-invasive approaches.

scholarly journals IMUNOSUPRESI UNTUK PENCANGKOKAN GINJAL (Bagian I)

2018 ◽  
Vol 14 (2) ◽  
pp. 72
Author(s):  
Suprapto Ma’at
Keyword(s):  
Kidney Transplantation ◽  
End Stage Renal Disease ◽  
Immunosuppressive Agents ◽  
Immunosuppressive Drugs ◽  
Phase 2 ◽  
Phase 3 ◽  
Allograft Function ◽  
Circulating Antibodies ◽  
Stage Renal Disease ◽  
End Stage

Renal transplantation is the treatment of choice for most patients with end stage renal disease. Most of the time, transplantationrejection is immunological mediated. Both T cells and circulating antibodies are induced against allograft. Successful organtransplantation requires the use of immunosuppressive drugs to prevent the host’s immune system from rejecting the transplanted organ.The development of immunosuppressive drugs is the key to successful allograft function Immunosuppressive agents are used for induction(intense immunosuppressant in the initial days after transplantation), maintenance and reversal of established rejection. This reviewfocuses on agents that are either approved or in phase 2 or phase 3 trials in kidney transplantation.

Recurrence of Primary Glomerular Diseases Post Kidney Transplantation

2019 ◽  
pp. 459-466
Author(s):  
John Manllo-Dieck ◽  
Nada Alachkar
Keyword(s):  
Kidney Transplantation ◽  
End Stage Renal Disease ◽  
De Novo ◽  
Close Monitoring ◽  
Allograft Survival ◽  
Glomerular Diseases ◽  
Common Cause ◽  
Primary Glomerular Diseases ◽  
Stage Renal Disease ◽  
End Stage

Glomerulonephritis (GN) is a common cause of end stage renal disease (ESRD), just behind diabetes and hypertension. Primary glomerular diseases may recur after transplant, or in some instances may present de novo. At times is difficult to differentiate between recurrence and de novo, due to misdiagnosis of the primary cause of ESRD and lack of tissue diagnosis prior to transplantation. All GNs can recur after transplantation, incidence and impact on allograft survival depends on the primary disease and immunosuppression being used. Close monitoring of patients with known GN is key, since early diagnosis and rapid intervention are crucial for allograft survival.

scholarly journals MENAHAN ATAU MENEKAN KEKEBALAN (IMUNOSUPRESI) UNTUK PENCANGKOKAN GINJAL (Bagian II)

2018 ◽  
Vol 14 (3) ◽  
pp. 112
Author(s):  
Suprapto Ma’at
Keyword(s):  
Kidney Transplantation ◽  
End Stage Renal Disease ◽  
Immunosuppressive Agents ◽  
Immunosuppressive Drugs ◽  
Phase 2 ◽  
Phase 3 ◽  
Allograft Function ◽  
Circulating Antibodies ◽  
Stage Renal Disease ◽  
End Stage

Renal transplantation is the treatment of choice for most patients with end stage renal disease. Most of the time, transplantationrejection is immunological mediated. Both T cells and circulating antibodies are induced against allograft. Successful organtransplantation requires the use of immunosuppressive drugs to prevent the host’s immune system from rejecting the transplanted organ.The development of immunosuppressive drugs is the key to successful allograft function Immunosuppressive agents are used for induction(intense immunosuppressant in the initial days after transplantation), maintenance and reversal of established rejection. This reviewfocuses on agents that are either approved or in phase 2 or phase 3 trials in kidney transplantation.

scholarly journals Providers’ View on the First Kidney Transplantation Center in Ethiopia: Experience From Past to Present

2021 ◽  
Vol 8 ◽  
pp. 233339282110183
Author(s):  
Tariku Shimels ◽  
Abrham Getachew ◽  
Mekdim Tadesse ◽  
Alison Thompson
Keyword(s):  
Kidney Transplantation ◽  
Renal Transplant ◽  
Health Care Providers ◽  
Study Data ◽  
Care Providers ◽  
Transplant Center ◽  
Transplantation Center ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Transplantation is the optimal management for patients with end-stage renal disease. In Ethiopia, the first national kidney transplantation center was opened at St. Paul’s Hospital Millennium Medical College in September 2015. The aim of this study was to explore providers’ views and experiences of the past to present at this center. Methods: A qualitative study design was employed from 1st November to 15th December, 2019. To ensure that appropriate informants would provide rich study data, 8 health care providers and top management members were purposefully chosen for in-depth interviews. A maximum variation sampling method was considered to include a representative sample of informants. Interviews were digitally audio-recorded, and transcribed verbatim. Transcribed data was coded and analyzed using Qualitative Data Analysis (QDA) Minor Lite software and Microsoft-Excel. Result: The participants (5 males and 3 females) approached were from different departments of the renal transplant center, and the main hospital. Eight main themes and 18 sub-themes were generated initially from all interviews totaling to 109 index codes. Further evaluation and recoding retained 5 main themes, and 14 sub-themes. The main themes are; challenges experienced during and after launching the center, commitment, sympathy and satisfaction, outcomes of renal transplant, actions to improve the quality of service, and how the transplant center should operate. Providers claim that they discharge their responsibilities through proper commitment and compassion, paying no attention to incentive packages. They also explained that renal transplantation would have all the outcomes related to economic, humanistic and clinical facets. Conclusion and Recommendation: A multitude of challenges were faced during and after the establishment of the first renal transplant center in Ethiopia. Providers discharge their responsibility through a proper compassion for patients. Concerned stakeholders should actively collaborate to improve the quality of renal transplant services in the center.

scholarly journals Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Irham Arif Rahman ◽  
Nur Rasyid ◽  
Ponco Birowo ◽  
Widi Atmoko
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Kidney Transplantation ◽  
Renal Transplantation ◽  
End Stage Renal Disease ◽  
Erectile Function ◽  
Meta Analysis ◽  
Post Transplantation ◽  
Stage Renal Disease ◽  
End Stage

AbstractErectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function.

Kidney transplantation in the extremely elderly from extremely aged deceased donors: a kidney for each age

2020 ◽  
Vol 35 (4) ◽  
pp. 687-696
Author(s):  
Jimena Cabrera ◽  
Mario Fernández-Ruiz ◽  
Hernando Trujillo ◽  
Esther González ◽  
María Molina ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Cox Regression ◽  
Patient Survival ◽  
Incidence Rates ◽  
Allocation Policy ◽  
Recipient Age ◽  
Deceased Donors ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Advances in life expectancy have led to an increase in the number of elderly people with end-stage renal disease (ESRD). Scarce information is available on the outcomes of kidney transplantation (KT) in extremely elderly patients based on an allocation policy prioritizing donor–recipient age matching. Methods We included recipients ≥75 years that underwent KT from similarly aged deceased donors at our institution between 2002 and 2015. Determinants of death-censored graft and patient survival were assessed by Cox regression. Results We included 138 recipients with a median follow-up of 38.8 months. Median (interquartile range) age of recipients and donors was 77.5 (76.3–79.7) and 77.0 years (74.7–79.0), with 22.5% of donors ≥80 years. Primary graft non-function occurred in 8.0% (11/138) of patients. Cumulative incidence rates for post-transplant infection and biopsy-proven acute rejection (BPAR) were 70.3% (97/138) and 15.2% (21/138), respectively. One- and 5-year patient survival were 82.1 and 60.1%, respectively, whereas the corresponding rates for death-censored graft survival were 95.6 and 93.1%. Infection was the leading cause of death (46.0% of fatal cases). The occurrence of BPAR was associated with lower 1-year patient survival [hazard ratio (HR) = 4.21, 95% confidence interval (CI) 1.64–10.82; P = 0.003]. Diabetic nephropathy was the only factor predicting 5-year death-censored graft survival (HR = 4.82, 95% CI 1.08–21.56; P = 0.040). Conclusions ESRD patients ≥75 years can access KT and remain dialysis free for their remaining lifespan by using grafts from extremely aged deceased donors, yielding encouraging results in terms of recipient and graft survival.

scholarly journals Significant Decrease in Plasma N-Acetyl-seryl-aspartyl-lysyl-proline Level in Patients with End Stage Renal Disease after Kidney Transplantation

2014 ◽  
Vol 37 (6) ◽  
pp. 1075-1079 ◽  
Author(s):  
Yosuke Suzuki ◽  
Fumihiko Katagiri ◽  
Fuminori Sato ◽  
Kanako Fujioka ◽  
Yukie Sato ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Proline Level ◽  
Stage Renal Disease ◽  
End Stage
Sign in / Sign up

Export Citation Format

Share Document