Prevalence of sleep breathing complaints reported by treatment-seeking chronic insomnia disorder patients on presentation to a sleep medical center: a preliminary report

2012 ◽  
Vol 17 (1) ◽  
pp. 317-322 ◽  
Author(s):  
Barry Krakow ◽  
Victor A. Ulibarri
2017 ◽  
Vol 59 (3) ◽  
pp. 45-51
Author(s):  
Lucille Malan ◽  
Nokuthula Dlamini

Insomnia disorder is defined as difficulty in falling asleep, maintaining sleep, and early morning awakenings. Common daytime consequences experienced are fatigue, mood instability and impaired concentration. In chronic insomnia these symptoms persist over a period of at least three months. Chronic insomnia can also be a symptom of a variety of disorders. The pathophysiology of insomnia is theorised as a disorder of nocturnal and daytime hyper-arousal as a result of increased somatic, cortical and cognitive activation. The causes of insomnia can be categorized into situational, medical, psychiatric and pharmacologically-induced. To diagnose insomnia, it is required to evaluate the daytime and nocturnal symptoms, as well as psychiatric and medical history. The Diagnostic and Statistical Manual 5 Criteria (DSM-5) also provides guidelines and criteria to be followed when diagnosing insomnia disorder. Goals of treatment for insomnia disorder are to correct the underlying sleep complaint and this, together with insomnia symptoms, their severity and duration, as well as co-morbid disorders will determine the choice of treatment. In the majority of patients, insomnia can be treated without pharmacological therapy and cognitive behavioural therapy is considered first-line therapy for all patients with insomnia. The most common pharmacological insomnia treatments include benzodiazepines and benzodiazepines receptor agonists. To avoid tolerance and dependence, these hypnotics are recommended to be used at the lowest possible dose, intermittently and for the shortest duration possible. A combination of cognitive behavioural therapy and pharmacological treatment options is recommended for chronic insomnia.


2020 ◽  
Vol Volume 12 ◽  
pp. 693-704
Author(s):  
Ping Zhang ◽  
Ying-Xue Li ◽  
Zhe-Zhe Zhang ◽  
Ye Yang ◽  
Ji-Xian Rao ◽  
...  

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e034421 ◽  
Author(s):  
Anastasia Suraev ◽  
Ronald R Grunstein ◽  
Nathaniel S Marshall ◽  
Angela L D'Rozario ◽  
Christopher J Gordon ◽  
...  

IntroductionInsomnia is a highly prevalent and costly condition that is associated with increased health risks and healthcare utilisation. Anecdotally, cannabis use is frequently reported by consumers to promote sleep. However, there is limited research on the effects of cannabis on sleep and daytime function in people with insomnia disorder using objective measures. This proof-of-concept study will evaluate the effects of a single dose of an oral cannabis-based medicine on sleep and daytime function in participants with chronic insomnia disorder.Methods and analysisA randomised, crossover, placebo-controlled, single-dose study design will be used to test the safety and efficacy of an oral oil solution (‘ETC120’) containing 10 mg Δ9-tetrahydrocannabinol (THC) and 200 mg cannabidiol (CBD) in 20 participants diagnosed with chronic insomnia disorder. Participants aged 35–60 years will be recruited over an 18-month period commencing August 2019. Each participant will receive both the active drug and matched placebo, in a counterbalanced order, during two overnight study assessment visits, with at least a 1-week washout period between each visit. The primary outcomes are total sleep time and wake after sleep onset assessed via polysomnography. In addition, 256-channel high-density electroencephalography and source modelling using structural brain MRI will be used to comprehensively examine brain activation during sleep and wake periods on ETC120 versus placebo. Next-day cognitive function, alertness and simulated driving performance will also be investigated.Ethics and disseminationEthics approval was received from Bellberry Human Research Ethics Committee (2018-04-284). The findings will be disseminated in a peer-reviewed open-access journal and at academic conferences.Trial registration numberANZCTRN12619000714189.


2016 ◽  
Vol 165 (12) ◽  
pp. 892 ◽  
Author(s):  
Devan Kansagara ◽  
Timothy J. Wilt ◽  
Melissa Starkey ◽  
Amir Qaseem

2019 ◽  
Vol 64 ◽  
pp. S101
Author(s):  
J. Edinger ◽  
C. Morin ◽  
S. Beaulieu-Bonneau ◽  
H. Ivers ◽  
A. Krystal ◽  
...  

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