CPAP therapy induces favorable short-term changes in epicardial fat thickness and vascular and metabolic markers in apparently healthy subjects with obstructive sleep apnea-hypopnea syndrome (OSAHS)

2015 ◽  
Vol 20 (2) ◽  
pp. 483-493 ◽  
Author(s):  
Konstantinos Kostopoulos ◽  
Emmanouil Alhanatis ◽  
Konstantinos Pampoukas ◽  
Georgios Georgiopoulos ◽  
Andromahi Zourla ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Healthy Subjects ◽  
Cpap Therapy ◽  
Short Term ◽  
Metabolic Markers ◽  
Epicardial Fat Thickness ◽  
Obstructive Sleep ◽  
Fat Thickness ◽  
Hypopnea Syndrome ◽  
Apparently Healthy

scholarly journals EFFECTS OF LONG-TERM CONTINUOUS POSITIVE AIRWAY PRESSURE THERAPY (CPAP) ON EPICARDIAL FAT THICKNESS AND ARTERIAL STIFFNESS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA AND HYPERTENSION

2019 ◽  
Vol 9 (1) ◽  
pp. 52-59
Author(s):  
M. V. Gorbunova ◽  
S. L. Babak ◽  
A. G. Malyavin
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Left Ventricular ◽  
Epicardial Fat ◽  
Cpap Therapy ◽  
Study Objective ◽  
Pressure Therapy ◽  
Epicardial Fat Thickness ◽  
Obstructive Sleep ◽  
Fat Thickness

Background:obstructive sleep apnea (OSA) is associated with high prevalence of arterial hypertension (AH), obesity, violation of carbohydrate metabolism and dyslipidemia. However, the effects of CPAP therapy to improve epicardial fat thickness of the OSA patient with AH the are poorly understood and poorly studied.Study objective:the aim of the study was to investigate 12-month effects of CPAP therapy with auto-adaptation to inhalation and exhalation of the OSA patient with AH and metabolic disorders (A-Flex therapy) on epicardial fat thickness (EFT).Methods:to the prospective single-center study were included 310 patients with OSA and AH (273 male, 45,3 ± 10,4 yr.) with apnea-hypopnea index (AHI) >5 events /hour. The night polygraphy study (PG) was performed to calculate AHI, oxygen desaturation index (ODI), mean nocturnal saturation (SpO 2 ) by the rules of American Academy of Sleep Medicine (AASM). The calculation of the epicardial fat thickness (EFT), the size and volume of the heart cavities, left ventricular mass index (LVMI) were performed by two-dimensional echocardiography. Endothelial functionof blood vessels determined by finger test was measured according to peripheral arterial tone (PAT). The reactive hyperemia index (RHI) and augmentation index (AI) was calculated. Optimal level of A-Flex therapy was adjusted at home. AHI, the level of air leakage, average pressure and compliance to CPAP treatment were established in accordance with international requirements.Results:after 3 months of A-Flex therapy we found a significant decrease of HOMA-IR -1,09 (95% Cl from -1,74 to -0,96; P=0,021), decrease AI -10.8% (95% Cl from -13,70 to -4.6; P=0,001), decrease EFT -1,26 mm (95% Cl from -2,2 to -0,95; P=0,001) in mild OSA patients. After 6 months of A-Flex therapy we found a significant decrease of HOMAIR -2,81 (95% Cl from -3,74 to -1,46; P=0,001), decrease AI -15.6 % (95% Cl from -17,23 to -11,75; P=0,001), decrease EFT -2,15mm (95% Cl from -3,2 to -1,5; P=0,001) in moderate OSA patients. After 12 months of A-Flex therapy we found a significant decrease of HOMA-IR -4,22 (95% Cl from -5,36 to -2,35; P=0,001), decrease AI -21,05 % (95% Cl from -26,5 to -17,4; P=0,001), decrease EFT -4,0 mm (95% Cl from-5,8 to -2,7; P=0,001) in severe OSA patients.Conclusions:The 12-month A-Flex therapy in moderate and severe OSA patients with AH has a significant therapeutic effect of stabilization systolic and diastolic blood pressure, level of blood lipids and epicardial fat thickness, level of endothelial dysfunction. The 12-month A-Flex therapy has to able to reduce the risks of cardiovascular events in moderate and severe OSA patients with acute metabolic manifestations.

scholarly journals Effectiveness of structured educational programs in increasing adherence to CPAP therapy in patients with obstructive sleep apnea/hypopnea syndrome

2016 ◽  
Vol 97 (4) ◽  
pp. 535-540
Author(s):  
A K Myrzaakhmatova ◽  
T M Sooronbaev
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Educational Program ◽  
Positive Airway Pressure ◽  
Cpap Therapy ◽  
Obstructive Sleep ◽  
The Creation ◽  
Hypopnea Syndrome

Aim. To study the effectiveness of a structured educational program in improving adherence to therapy with the creation of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea/hypopnea syndrome.Methods. The study included 40 patients with moderate to severe obstructive sleep apnea/hypopnea syndrome, who received CPAP therapy. Patients were divided into two groups: the first group (main) - 20 patients who had undergone training according to a specially designed structured educational program, the second group (control) - 20 patients who had not received training. CPAP therapy was considered as effective in case of reducing the apnea-hypopnea index to less than 5 per hour of sleep, with an average duration of the machine use for the night was to be more than 5 hours.Results. Using a structured educational program in patients of the main (first) group showed a good adherence of patients and the effectiveness of CPAP therapy. Positive dynamics of clinical symptoms, in particular a decrease in daytime sleepiness, assessed according to Epworth sleepiness scale (17.1±4.2 vs. 3.9±1.6; p=0,0000), was registered, the number of pauses in breathing during the night significantly reduced (44.37±14.6 vs. 2.86±3.5 per hour; p=0,0000), accompanied by improvement of night saturation parameters: SpO2min (58.4±9.0 vs. 78.0±9.3; p=0,0000), SpO2mean (87.2±6.8 vs. 93.1±3.5; p=0,0018). Against this background, after 3 months of therapy a decrease in body mass index and blood pressure was registered.Conclusion. The implementation of a structured educational program showed increase in adherence and the effectiveness of therapy with the creation of continuous positive airway pressure (CPAP therapy) in treating obstructive sleep apnea/hypopnea syndrome.

Association of epicardial fat thickness with the severity of obstructive sleep apnea in obese patients

2013 ◽  
Vol 167 (5) ◽  
pp. 2244-2249 ◽  
Author(s):  
Stefania Mariani ◽  
Daniela Fiore ◽  
Giuseppe Barbaro ◽  
Sabrina Basciani ◽  
Maurizio Saponara ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Epicardial Fat ◽  
Obese Patients ◽  
Epicardial Fat Thickness ◽  
Obstructive Sleep ◽  
Fat Thickness

Gender-Related Changes of the Epicardial Fat Thickness and Leptin in Obstructive Sleep Apnea

2013 ◽  
Vol 31 (4) ◽  
pp. 411-419 ◽  
Author(s):  
Hakan Akilli ◽  
Mehmet Kayrak ◽  
Taha Tahir Bekci ◽  
Halil İbrahim Erdogan ◽  
Alpay Aribas ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Epicardial Fat ◽  
Epicardial Fat Thickness ◽  
Obstructive Sleep ◽  
Fat Thickness

scholarly journals Efficacy and adherence of auto-CPAP therapy in patients with obstructive sleep apnea: a prospective study

2020 ◽  
Vol 15 ◽  
Author(s):  
Hang Dinh-Thi-Dieu ◽  
Anh Vo-Thi-Kim ◽  
Huong Tran-Van ◽  
Sy Duong-Quy
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Nasal Congestion ◽  
Apnea Hypopnea Index ◽  
Cpap Therapy ◽  
Short Term ◽  
Arousal Index ◽  
Obstructive Sleep ◽  
A Prospective Study

Introduction: The use of auto-continuous positive airway pressure (auto-CPAP) therapy has been recommended for subjects with moderate-to-severe obstructive sleep apnea (OSA) without significant comorbidities. This study is aimed at evaluating the efficacy and adherence of auto-CPAP therapy in subjects with OSA. Methods: It was a perspective and descriptive study. All study subjects who had apnea-hypopnea index (AHI) >30/h, measured by polysomnography, were included. They were treated with auto-CPAP and followed-up for 6 months for evaluating the effect of CPAP-therapy on clinical and biological features and treatment adherence. Results: One hundred and thirty-nine subjects with severe OSA were accepted for auto-CPAP therapy at inclusion. BMI was 28.4±3.8 kg/m2; neck and abdomen circumferences were 38.2±6.4 and 85.7±11.6. Epworth and Pichot scores were 18.4±6.3 and 28.3±4.5, respectively; AHI was 39±7/h and arousal index was 39±13/hour. At 6th month, 96.4% of study subjects continued to use auto-CPAP-therapy within 6.5±2.4 hours/night. There was a significant correlation between the modification (Δ) of Epworth scores and (Δ) AHI after 3 and 6 months of auto-CPAP-therapy (R=0.568 and P=0.003; R=0.745 and P=0.002; respectively). At 6th month follow-up, the main side effects of auto-CPAP were difficult sleeping, dry mouth or nose, skin marks or rashes, discomfortable breathing, and nasal congestion (36.1%, 32.0%, 20.8%, 16.0%, and 11.9%; respectively). Conclusion: Auto-CPAP is effective in treatment of Vietnamese patients with severe OSA in short-term follow-up.

Sign in / Sign up

Export Citation Format

Share Document