Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats

2015 ◽  
Vol 25 (8) ◽  
pp. 7223-7230 ◽  
Author(s):  
Vesna Milovanovic ◽  
Aleksandra Buha ◽  
Vesna Matovic ◽  
Marijana Curcic ◽  
Slavica Vucinic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Renal Toxicity ◽  
Diphenyl Ether ◽  
Subacute Exposure

Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats

Drug Research ◽  
2018 ◽  
Vol 68 (12) ◽  
pp. 696-703 ◽  
Author(s):  
Abdulwasiu Busari ◽  
Abdullahi Adejare ◽  
Abiodun Shodipe ◽  
Oludaisi Oduniyi ◽  
Khadijah Ismail-Badmus ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Creatinine Level ◽  
Wistar Rats ◽  
Renal Toxicity ◽  
Nigella Sativa ◽  
Synergistic Effects ◽  
Sodium Concentration ◽  
Urea Level ◽  
And Oxidative Stress

Abstract Background Cisplatin is an anti-cancer drug that causes nephrotoxicity and oxidative stress. Extracts of Nigella sativa is nephroprotective. Vitamin E is also a potent antioxidant. This study sought to determine a possible synergistic effect of administering the two agents prior to cisplatin use on nephrotoxicity and oxidative stress. Methods 48 male Wistar rats were randomly divided into 6 groups of 8 rats each. Group I served as the control. Group II received cisplatin without any treatment for 6 days. Groups III, IV, V and VI received 100 mg/kg Nigella sativa (NS), 200 mg/kg NS, 100 mg/kg Vitamin E and 200 mg/kg NS+100 mg/kg Vitamin E respectively for 5 days prior to 6 days administration of cisplatin. On the last day of the experiment, all the animals were sacrificed and serum samples collected for analysis. Results Cisplatin administration caused a significant increase in creatinine level (p<0.01), urea level (p<0.01), sodium concentration and malondialdehyde level (p<0.001). Pre-administration with NS caused a significant reduction in creatinine level (p<0.001), urea level (p<0.001), sodium concentration (p<0.001) and malondialdehyde (p<0.01) level. Pre-administration with vitamin E caused a significant reduction in creatinine level (p<0.001), urea level (p<0.01), sodium concentration (p<0.001) and malondialdehyde level. They both also caused a significant increase in superoxide dismutase, reduced glutathione and catalase (CAT) levels. The combination of NS and vitamin E however did not show significant synergistic effects. Conclusion These results suggest that even though pre-administration of the two agents protect against renal toxicity and oxidative stress, the effects are however not collaborative.

scholarly journals Annona muricata Attenuates Cadmium-Induced Oxidative Stress and Renal Toxicity in Wistar Rats

2019 ◽  
Vol 5 (4) ◽  
pp. 543-550
Author(s):  
Johnson Oladele ◽  
Olu Oyewole ◽  
Moses Oyeleke ◽  
Omowumi Adewale ◽  
Oluwamuyiwa Adeloju
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Renal Toxicity ◽  
Annona Muricata

Abrogation of 5-flourouracil induced renal toxicity by bee propolis via targeting oxidative stress and inflammation in Wistar rats

2013 ◽  
Vol 7 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Summya Rashid ◽  
Nemat Ali ◽  
Sana Nafees ◽  
Shiekh Tanveer Ahmad ◽  
Syed Kazim Hasan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Renal Toxicity

Oxidative stress responses in Wistar rats on subacute exposure to pharmaceutical wastewater

2016 ◽  
Vol 23 (23) ◽  
pp. 24158-24165 ◽  
Author(s):  
Ali Sharif ◽  
Muhammad Ashraf ◽  
Aqeel Javeed ◽  
Aftab Ahmed Anjum ◽  
Muhammad Furqan Akhtar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Responses ◽  
Wistar Rats ◽  
Pharmaceutical Wastewater ◽  
Oxidative Stress Responses ◽  
Subacute Exposure

Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats

2014 ◽  
Vol 66 ◽  
pp. 185-193 ◽  
Author(s):  
Summya Rashid ◽  
Nemat Ali ◽  
Sana Nafees ◽  
Syed Kazim Hasan ◽  
Sarwat Sultana
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Renal Toxicity

Effects of Chronic Exposure to Electromagnetic Waves at 930 MHz Frequency on Oxidative Stress in Plasma and Some Organs of Wistar Rats

2012 ◽  
Vol 3 (7) ◽  
pp. 1-7
Author(s):  
L. TAZROUT L. TAZROUT ◽  
◽  
K. TALEA K. TALEA ◽  
S. EL AMRANI S. EL AMRANI ◽  
I. M’TOUGUY I. M’TOUGUY ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Exposure ◽  
Electromagnetic Waves ◽  
Wistar Rats

Thymus Vulgaris Inhibit Lung Fibrosis Progression and Oxidative Stress Induced by Bleomycin in Wistar Rats

2021 ◽  
pp. 1-11
Author(s):  
Sana Bahri ◽  
Mona Mlika ◽  
Afef Nahdi ◽  
Ridha Ben Ali ◽  
Saloua Jameleddine
Keyword(s):  
Oxidative Stress ◽  
Lung Fibrosis ◽  
Wistar Rats ◽  
Thymus Vulgaris ◽  
Fibrosis Progression ◽  
And Oxidative Stress
Sign in / Sign up

Export Citation Format

Share Document