Protective effect of alpha-lipoic acid on di-(2-ethylhexyl) phthalate-induced testicular toxicity in mice

2020 ◽  
Vol 27 (12) ◽  
pp. 13670-13678 ◽  
Author(s):  
Mehdi Goudarzi ◽  
Mojtaba Haghi Karamallah ◽  
Alireza Malayeri ◽  
Mojtaba Kalantar ◽  
Esrafil Mansouri ◽  
...  
Keyword(s):  
Protective Effect ◽  
Lipoic Acid ◽  
Testicular Toxicity ◽  
Alpha Lipoic Acid ◽  
Ethylhexyl Phthalate

scholarly journals Melatonin and alpha lipoic acid attenuate lopinavir/ritonavir - induced testicular toxicity in albino rats

2016 ◽  
Vol 62 (2) ◽  
pp. 17-24
Author(s):  
Elias Adikwu ◽  
Brambaifa Nelson ◽  
Wolfe Atuboyedia Obianime
Keyword(s):  
Lipoic Acid ◽  
Serum Testosterone ◽  
Sperm Parameters ◽  
Oral Exposure ◽  
Albino Rats ◽  
Sperm Cells ◽  
Testicular Toxicity ◽  
Alpha Lipoic Acid ◽  
Testosterone Levels ◽  
Oral Doses

The use of lopinavir/ritonavir (LPV/r) could be associated with testicular toxicity as a limiting factor. The present study evaluated the effects of melatonin (MT) and alpha lipoic (ALA) acid on LPV/r–induced testicular toxicity in male albino rats. Eighty five male albino rats used for this study were randomized into 6 groups (A-F). Rats in groups A1 and A2 served as placebo and solvent control and were orally exposed to water and 1% ethanol, respectively. Rats in group B were exposed to oral doses of MT (10 mg kg-1/day), ALA (10 mg kg-1/day) and combined doses of MT and ALA, respectively. Rats in group C were exposed to oral doses of LPV/r (22.9/5.71 - 91.4/22.9 mg kg-1/ day), respectively. Rats in group D-F were exposed to oral doses of MT (10 mg kg-1/day), ALA (10 mg kg-1/day) and combined doses of MT and ALA prior to oral exposure to LPV/r (22.9/5.71 - 91.4/22.9 mg kg-1/day), respectively. At the end of 60 days of exposure to drugs, rats were sacrificed; blood was collected and serum extracted and evaluated for testosterone. Testes were collected and evaluated for sperm parameters. LPV/r-treated rats showed significant (P<0.05) and dose-dependent decreases in sperm count, sperm motility, sperm viability and serum testosterone levels with increases in abnormal sperm cells, debris, and primordial sperm cells when compared to placebo control. However, LPV/r-induced changes in sperm parameters and serum testosterone levels were attenuated in rats pretreated with MT and ALA. The best effects were observed in rats pretreated with combined doses of MT and ALA. Melatonin and alpha lipoic acid have potential to reduce testicular toxicity associated with lopinavir/ritonavir treatment.

The Protective Effect Of Alpha-Lipoic Acid On Ventilator And Lipopolysaccharide-Induced Lung Injury In Rats

2011 ◽  
Author(s):  
Hung Chang ◽  
Yu-Chien Kung ◽  
Shih-Chun Lee ◽  
Chung-Cheng Kao ◽  
Chia-Yu Chang ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effect ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid

Protective Effect of Alpha-lipoic Acid Against Lead Acetate-Induced Oxidative Stress in the Bone Marrow of Rats

2011 ◽  
Vol 7 (2) ◽  
pp. 217-227 ◽  
Author(s):  
Nagaraja Haleagraha ◽  
Tan Jackie ◽  
Srikumar Chakravart ◽  
Anupama Bangra Kulur
Keyword(s):  
Oxidative Stress ◽  
Bone Marrow ◽  
Protective Effect ◽  
Lipoic Acid ◽  
Lead Acetate ◽  
Alpha Lipoic Acid

Protective effect of alpha-lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

2016 ◽  
Vol 44 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Dilek Özbeyli ◽  
Ayşe Cansu Berberoglu ◽  
Anıl Özen ◽  
Oktay Erkan ◽  
Yunus Başar ◽  
...  
Keyword(s):  
Protective Effect ◽  
Resistance Exercise ◽  
Lipoic Acid ◽  
Second Hand Smoke ◽  
Alpha Lipoic Acid ◽  
Young Rats

scholarly journals Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats

2019 ◽  
Vol 10 ◽  
Author(s):  
Jia Jia ◽  
Xiaoying Gong ◽  
Yang Zhao ◽  
Zhenyu Yang ◽  
Kaiqiang Ji ◽  
...  
Keyword(s):  
Protective Effect ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid
Sign in / Sign up

Export Citation Format

Share Document