Is micronucleus assay in oral exfoliated cells a suitable tool for biomonitoring children exposed to environmental pollutants? A systematic review

2021 ◽  
Author(s):  
Ingra Tais Malacarne ◽  
Daniel Vitor De Souza ◽  
Maria Esther Suarez Alpire ◽  
Ana Carolina Flygare Souza ◽  
Ana Claudia Muniz Renno ◽  
...  
Keyword(s):  
Systematic Review ◽  
Environmental Pollutants ◽  
Micronucleus Assay ◽  
Suitable Tool ◽  
Exfoliated Cells

The improved Allium/Vicia root tip micronucleus assay for clastogenicity of environmental pollutants

1995 ◽  
Vol 334 (2) ◽  
pp. 185-195 ◽  
Author(s):  
Te-Hsiu Ma ◽  
Zhidong Xu ◽  
Chengen Xu ◽  
Heike McConnell ◽  
Eugenia Valtierra Rabago ◽  
...  
Keyword(s):  
Environmental Pollutants ◽  
Micronucleus Assay ◽  
Root Tip

Cytological assays for the evaluation of genotoxicity in plants: A review

2014 ◽  
Vol 4 (4) ◽  
pp. 141-149
Author(s):  
Sazada Siddiqui
Keyword(s):  
Comet Assay ◽  
Chromosomal Aberration ◽  
Environmental Pollutants ◽  
Genetic Material ◽  
Micronucleus Assay ◽  
Short Term ◽  
Metabolic System ◽  
Action Mechanisms ◽  
Chromosomal Aberration Assay ◽  
Aneugenic Effects

Plants model are recognized as excellent genetic models to detect environ-mental mutagens and are frequently used in xenomoitoring studies. Several assays such as chromosomal aberration assay, micronucleus assay and comet assay are used for detecting the mutagenicity, cytotoxicity and genotoxicity of environmental pollutants. It is easily handled and has advantages over other short-term tests that require pervious preparation of tested samples as well as the addition of exogenous metabolic system. Plants model also enables to evaluate different end points such as chromosomal aberration assay (CAA), micronucleus assay (MNA) and comet assay (CA) that have been used to detect genotoxicity of environmental pollutants. In addition, plants model provides important information to evaluate action mechanisms of an agent about its effects on the genetic material (clastogenic and/or aneugenic effects). It has been widely used to assess the impacts caused by xenobiotic, characterizing an important tool for environmental monitoring studies. The present review describes the two important assays using plant models that are appropriate and efficient cytogenetic materials for the detection of geno-toxicity of environmental pollutants.

Exposure to ambient gaseous air pollutants and adult lung function: a systematic review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Kazhal Masroor ◽  
Mansour Shamsipour ◽  
Ramin Mehrdad ◽  
Farzad Fanaei ◽  
Mina Aghaei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Air Pollutants ◽  
Environmental Pollutants ◽  
Premature Mortality ◽  
Epidemiological Studies ◽  
Chronic Obstructive ◽  
Hazardous Air Pollutants ◽  
Mortality Factors ◽  
Obstructive Pulmonary Disease

Abstract Exposure to hazardous air pollutants is identified as most obvious premature mortality factors in the world. Numerous epidemiological studies have estimated exposure to air pollutants may cause pulmonary toxicity and the incidence of respiratory diseases including chronic obstructive pulmonary disease (COPD), chronic bronchitis and asthma. The currently research was performed to evaluation the association between gaseous pollutants and lung function in healthy adults. Articles related to this study were selected from researches of Scopus, PubMed, and Web of Science databases. A total of 2,644 articles were retrieved and 39 records were reviewed after removing duplicates and excluding irrelevant studies. The result of this systematic review indicated that there is some evidence on decreasing lung function with exposure to gaseous air pollutants (NO2, SO2, and O3) which can have negative effects on human health. Although according to the evidence changes in lung function are mostly linked to the exposure to environmental pollutants including CO, O3, NO2 and SO2, the results should be interpreted with caution considering some following issues discussed in this review. Therefore, further studies are required considering well-designed studies in large scales to strengthen the evidence.

Smartphones, Suitable Tool for Driver Behavior Recognition. A Systematic Review

2020 ◽  
pp. 233-242
Author(s):  
Jovan F. Fernández Joya ◽  
Gabriel Ávila Buitrago ◽  
Huizilopoztli Luna-García ◽  
Wilson J. Samiento
Keyword(s):  
Systematic Review ◽  
Driver Behavior ◽  
Behavior Recognition ◽  
Suitable Tool

The micronucleus assay in exfoliated cells of the human buccal mucosa

Mutagenesis ◽  
1987 ◽  
Vol 2 (1) ◽  
pp. 11-17 ◽  
Author(s):  
F. Sarto ◽  
S. Finotto ◽  
L. Giacomelli ◽  
D. Mazzotti ◽  
R. Tomanin ◽  
...  
Keyword(s):  
Buccal Mucosa ◽  
Micronucleus Assay ◽  
Exfoliated Cells ◽  
Human Buccal Mucosa

scholarly journals Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review

2021 ◽  
Vol 11 (6) ◽  
pp. 500
Author(s):  
Margherita Ferrante ◽  
Antonio Cristaldi ◽  
Gea Oliveri Conti
Keyword(s):  
Systematic Review ◽  
Environmental Exposure ◽  
Environmental Pollutants ◽  
Altered Expression ◽  
Toxicological Assessment ◽  
Cellular Processes ◽  
Global Issue ◽  
Meta Analyses ◽  
The Relationship

The daily environmental exposure of humans to plasticizers may adversely affect human health, representing a global issue. The altered expression of microRNAs (miRNAs) plays an important pathogenic role in exposure to plasticizers. This systematic review summarizes recent findings showing the modified expression of miRNAs in cancer due to exposure to plasticizers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, we performed a systematic review of the literature published in the past 10 years, focusing on the relationship between plasticizer exposure and the expression of miRNAs related to cancer. Starting with 535 records, 17 articles were included. The results support the hypothesis that exposure to plasticizers causes changes in or the deregulation of a number of oncogenic miRNAs and show that the interaction of plasticizers with several redundant miRNAs, such as let-7f, let-7g, miR-125b, miR-134, miR-146a, miR-22, miR-192, miR-222, miR-26a, miR-26b, miR-27b, miR-296, miR-324, miR-335, miR-122, miR-23b, miR-200, miR-29a, and miR-21, might induce deep alterations. These genotoxic and oncogenic responses can eventually lead to abnormal cell signaling pathways and metabolic changes that participate in many overlapping cellular processes, and the evaluation of miRNA-level changes can be a useful target for the toxicological assessment of environmental pollutants, including plastic additives and plasticizers.

scholarly journals Oncogenic Role of miRNA by Environmental Exposure to Plasticizers: A Systematic Review.

2021 ◽  
Author(s):  
Margherita Ferrante ◽  
Antonio Cristaldi ◽  
Gea Oliveri Conti
Keyword(s):  
Systematic Review ◽  
Environmental Exposure ◽  
Environmental Pollutants ◽  
Altered Expression ◽  
Toxicological Assessment ◽  
Cellular Processes ◽  
Global Issue ◽  
Meta Analyses ◽  
The Relationship

The environmental exposure of human in the daily and occupational activities to plasticizers may adversely affect human health, and thus represents a global issue. The altered expression of MicroRNAs (miRNAs) exerts an important pathogenic role linked also to the exposure to plasticizers. This systematic review summarizes the recent findings showing modified ex-pression of miRNAs in cancer due to plasticizers exposures. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, we performed a systematic review of the past ten years, focusing on the relationship between plasticizer exposures and expression of miRNAs cancer. Starting by 535 records, 17 articles were included. Results support the hypothesis that exposure to plasticizers cause changes or deregulation of a number of oncogenic miRNAs and showed that plasticizers interaction with several redundant miRNAs, such as let-7f, let-7g, miR-125b, miR-134, miR-146a, miR-22; miR-192, miR-222, miR-26a, miR-26b, miR-27b, miR-296, miR-324, miR-335, miR-122, miR-23b, miR-200, miR-29a and miR-21, might induce deep alterations. These genotoxic and oncogenic responses can eventually lead to abnormal cell signaling pathways and metabolisms that participate in many overlapped cellular processes, and miRNA level changes can be a useful tool for the toxicological assessment of environmental pollutants, including plastic additives and plasticizers

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