The associations of urinary DEHP metabolite levels, serum thyroid hormones, and thyroid-related genes among the adolescent students from China: a cross-sectional study

Author(s):  
Yaming Zhao ◽  
Xinyue Song ◽  
Shuang Ding ◽  
Wen Qi ◽  
Yuezhu Zhang ◽  
...  
Author(s):  
Blanca Sarzo ◽  
Virginia Ballesteros ◽  
Carmen Iñiguez ◽  
Cyntia B. Manzano-Salgado ◽  
Maribel Casas ◽  
...  

2021 ◽  
Author(s):  
Yanli Li ◽  
Min Yi ◽  
Xiaoyi Deng ◽  
Wangen Li ◽  
Yimei Chen ◽  
...  

Abstract Background Diabetes mellitus (DM) and thyroid dysfunction (TD) are two closely associated disorders. The coexistence of TD could adversely influence metabolic control and even increase the long-term mortality in patients with DM. The objective of the present study was to investigate the thyroid status and the relationship between thyroid hormones, diabetic complications and metabolic parameters in patients with newly diagnosed type 2 DM (T2DM). Methods This is an observational cross-sectional study, conducting on 340 patients with newly diagnosed T2DM who were admitted to ward of endocrinology department and 120 matched nondiabetic subjects. Clinical characteristics were collected and laboratory measurements were conducted. Results Levels of free T3 (FT3), free T4 (FT4) and TSH were significantly lower in patients with T2DM as compared to nondiabetic subjects. The prevalence of TD was 21.2% in patients with diabetes, higher than that of controls (4.2%). The low T3 syndrome was the most frequent TD, shown in 14.7% of patients. The presence of diabetic complications (diabetic nephropathy (DN), diabetic ketosis), metabolic and demographic factors, including age, glycemic control and insulin resistance were factors associated with levels of thyroid hormones. FT3 level was inversely correlated with the level of urinary total protein (mg/24h) and the presence of DN. Multivariate analysis indicated low FT3 level as a strong independent risk factor (OR = 0.364, P < 0.001) for DN. Conclusions TD is not rarely seen in patients with newly diagnosed T2DM. Diabetic complications and diabetes-related metabolic and demographic factors are related to TD. Decreased FT3 is strongly correlated with the presence of DN.


2020 ◽  
Author(s):  
Mengesha Srah ◽  
Enguday Tirfeneh

Abstract Background: World Health Organization has documented many health risks and complications secondary to unprotected sexual activity among adolescents. Even though the impact of risky sexual practice on the general health of adolescents is enormous, little attention has been given on identification and intervention plans. Therefore, the aim of this study was to find magnitude of risky sexual behavior and associated factors among adolescents in high schools at Aksum town, Tigray, Ethiopia. Methods: we conducted a facility-based cross-sectional study at Aksum town. A systematic random sampling technique was applied. Data was collected with face to face interview and analyzed using statistical package for social science version 22. we have done bivariate and multivariate logistic regression. Adjusted Odds ratio at a p-value <0.05 with 95% confidence interval was taken to declare statistical significance. Result: A total of 644 students were participated with a response rate of 97.7%. Prevalence of risky sexual behavior was found to be 17.2%. Factors like poor social support [AOR=5.59, 95% CI: 2.71-11.53], living out of family [AOR=1.93, 95% CI: 1.21-3.07], experiencing parental neglect [AOR=1.87, 95% CI: 1.18-2.94] and drinking alcohol [AOR=2.55, 95% CI: 1.55-4.20] were statistically associated with risky sexual behavior. Conclusion: An alarming proportion of adolescent students have participated in risky sexual behavior. This can significantly affect health quality in the community and the country at large. Factors, like having poor social support, living out of the family, experiencing parental neglect and using alcoholic beverages are risk factors that increase the odds of risky sexual behavior among adolescent students.


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