scholarly journals T lymphocyte depletion ameliorates age-related metabolic impairments in mice

GeroScience ◽  
2021 ◽  
Author(s):  
Daniel W. Trott ◽  
Md Torikul Islam ◽  
David J. Buckley ◽  
Anthony J. Donato ◽  
Tavia Dutson ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Depletion ◽  
Age Related ◽  
Metabolic Impairments

B and T Lymphocyte Subsets in Fetal and Cord Blood: Age-Related Modulation of CD1c Expression

Neonatology ◽  
1993 ◽  
Vol 63 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Anna Plebani ◽  
Anna Rita Proserpio ◽  
Daniela Guarneri ◽  
Mauro Buscaglia ◽  
Giorgio Cattoretti
Keyword(s):  
Cord Blood ◽  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
T Lymphocyte Subsets ◽  
Age Related

scholarly journals Peripheral T lymphocyte depletion by apoptosis after CD4 ligation in vivo: selective loss of CD44− and ‘activating’ memory T cells

2008 ◽  
Vol 95 (1) ◽  
pp. 195-200 ◽  
Author(s):  
S. E. M. HOWIE ◽  
A. J. SOMMERFIELD ◽  
E. GRAY ◽  
D. J. HARRISON
Keyword(s):  
T Cells ◽  
T Lymphocyte ◽  
Memory T Cells ◽  
Lymphocyte Depletion ◽  
Selective Loss

Normalization of CD4+ T-Lymphocyte Depletion in Patients Without HIV Infection Treated for Tuberculosis

CHEST Journal ◽  
1994 ◽  
Vol 105 (5) ◽  
pp. 1335-1337 ◽  
Author(s):  
Glenn S. Turett ◽  
Edward E. Telzak
Keyword(s):  
Hiv Infection ◽  
T Lymphocyte ◽  
Lymphocyte Depletion

scholarly journals Corticosteroid Immunosuppression and Monoclonal Antibody-mediated CD5+ T Lymphocyte Depletion in Normal and Equine Infectious Anaemia Virus-carrier Horses

1994 ◽  
Vol 75 (5) ◽  
pp. 959-968 ◽  
Author(s):  
D. B. Tumas ◽  
M. T. Hines ◽  
L. E. Perryman ◽  
W. C. Davis ◽  
T. C. McGuire
Keyword(s):  
Monoclonal Antibody ◽  
T Lymphocyte ◽  
Lymphocyte Depletion ◽  
Equine Infectious Anaemia Virus ◽  
Virus Carrier

scholarly journals CD8+ Lymphocytes Do Not Mediate Protection against Acute Superinfection 20 Days after Vaccination with a Live Attenuated Simian Immunodeficiency Virus

2005 ◽  
Vol 79 (19) ◽  
pp. 12264-12272 ◽  
Author(s):  
Richard Stebbings ◽  
Neil Berry ◽  
Herman Waldmann ◽  
Pru Bird ◽  
Geoff Hale ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Lymphocytes ◽  
Simian Immunodeficiency Virus ◽  
Cytotoxic T Lymphocytes ◽  
T Lymphocyte ◽  
Lymphoid Tissue ◽  
Human Immunoglobulin ◽  
Wild Type ◽  
Lymphocyte Depletion ◽  
Immunodeficiency Virus

ABSTRACT In order to test the hypothesis that CD8+ cytotoxic T lymphocytes mediate protection against acute superinfection, we depleted >99% of CD8+ lymphocytes in live attenuated simian immunodeficiency virus macC8 (SIVmacC8) vaccinees from the onset of vaccination, maintained that depletion for 20 days, and then challenged with pathogenic, wild-type SIVmacJ5. Vaccinees received 5 mg per kg of humanized anti-CD8 monoclonal antibody (MAb) 1 h before inoculation, followed by the same dose again on days 3, 7, 10, 13, and 17. On day 13, peripheral CD8+ T lymphocytes were >99% depleted in three out of four anti-CD8 MAb-treated vaccinees. At this time attenuated SIVmacC8 viral RNA loads in anti-CD8 MAb-treated vaccinees were significantly higher than control vaccinees treated contemporaneously with nonspecific human immunoglobulin. Lymphoid tissue CD8+ T lymphocyte depletion was >99% in three out of four anti-CD8 MAb-treated vaccinees on the day of wild-type SIVmacJ5 challenge. All four control vaccinees and three out of four anti-CD8 MAb-treated vaccinees were protected against detectable superinfection with wild-type SIVmacJ5. Although superinfection with wild-type SIVmacJ5 was detected at postmortem in a single anti-CD8 MAb-treated vaccinee, this did not correlate with the degree of preceding CD8+ T lymphocyte depletion. Clearance of attenuated SIVmacC8 viremia coincided with recovery of normal CD8+ T lymphocyte counts between days 48 and 76. These results support the view that cytotoxic T lymphocytes are important for host-mediated control of SIV primary viremia but do not indicate a central role in protection against acute superinfection conferred by inoculation with live attenuated SIV.

scholarly journals Effects of T-Lymphocyte Depletion on Muscle Fibrosis in the mdx Mouse

2005 ◽  
Vol 166 (6) ◽  
pp. 1701-1710 ◽  
Author(s):  
Jamie Morrison ◽  
Donald B. Palmer ◽  
Stephen Cobbold ◽  
Terence Partridge ◽  
George Bou-Gharios
Keyword(s):  
T Lymphocyte ◽  
Mdx Mouse ◽  
Lymphocyte Depletion ◽  
Muscle Fibrosis

Age-related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL-associated serine esterase genes and the perforin gene in mice

1990 ◽  
Vol 20 (10) ◽  
pp. 2309-2316 ◽  
Author(s):  
Eda T. Bloom ◽  
Hisanori Umehara ◽  
R. Chris Bleackley ◽  
Ko Okumura ◽  
Howard Mostowski ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Serine Esterase ◽  
Age Related ◽  
Ctl Activity

T-Lymphocyte depletion and lesions of choroid plexus and kidney induced by tertiary amines in rats

1977 ◽  
Vol 40 (1) ◽  
pp. 147-159 ◽  
Author(s):  
Seymour Levine ◽  
Richard Sowinski
Keyword(s):  
Choroid Plexus ◽  
T Lymphocyte ◽  
Tertiary Amines ◽  
Lymphocyte Depletion

scholarly journals Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)

1999 ◽  
Vol 73 (2) ◽  
pp. 976-984 ◽  
Author(s):  
Mark Cayabyab ◽  
Gunilla B. Karlsson ◽  
Bijan A. Etemad-Moghadam ◽  
Wolfgang Hofmann ◽  
Tavis Steenbeke ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Mononuclear Cells ◽  
Rhesus Macaques ◽  
Envelope Glycoproteins ◽  
Peripheral Blood Mononuclear ◽  
Lymphocyte Depletion ◽  
Immunodeficiency Virus

ABSTRACT In vivo passage of a poorly replicating, nonpathogenic simian-human immunodeficiency virus (SHIV-HXBc2) generated an efficiently replicating virus, KU-1, that caused rapid CD4+T-lymphocyte depletion and AIDS-like illness in monkeys (S. V. Joag, Z. Li, L. Foresman, E. B. Stephens, L.-J. Zhao, I. Adany, D. M. Pinson, H. M. McClure, and O. Narayan, J. Virol. 70:3189–3197, 1996). The env gene of the KU-1 virus was used to create a molecularly cloned virus, SHIV-HXBc2P 3.2, that differed from a nonpathogenic SHIV-HXBc2 virus in only 12 envelope glycoprotein residues. SHIV-HXBc2P 3.2 replicated efficiently and caused rapid and persistent CD4+ T-lymphocyte depletion in inoculated rhesus macaques. Compared with the envelope glycoproteins of the parental SHIV-HXBc2, the SHIV-HXBc2P 3.2 envelope glycoproteins supported more efficient infection of rhesus monkey peripheral blood mononuclear cells. Both the parental SHIV-HXBc2 and the pathogenic SHIV-HXBc2P 3.2 used CXCR4 but none of the other seven transmembrane segment receptors tested as a second receptor. Compared with the parental virus, viruses with the SHIV-HXBc2P 3.2 envelope glycoproteins were more resistant to neutralization by soluble CD4 and antibodies. Thus, changes in the envelope glycoproteins account for the ability of the passaged virus to deplete CD4+ T lymphocytes rapidly and specify increased replicative capacity and resistance to neutralization.

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