In vivo growth-inhibition of Sarcoma 180 by an α-(1 → 4)-glucan–β-(1 → 6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill

2008 ◽  
Vol 63 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Maria Leônia Costa Gonzaga ◽  
Daniel Pereira Bezerra ◽  
Ana Paula Negreiros Nunes Alves ◽  
Nylane Maria Nunes de Alencar ◽  
Rodney de Oliveira Mesquita ◽  
...  
2006 ◽  
Vol 39 (6) ◽  
pp. 801-807 ◽  
Author(s):  
D.P. Bezerra ◽  
F.O. Castro ◽  
A.P.N.N. Alves ◽  
C. Pessoa ◽  
M.O. Moraes ◽  
...  

2007 ◽  
Vol 69 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Alessandra Paula Alves de Sousa ◽  
Márcia Rocha Torres ◽  
Cláudia Pessoa ◽  
Manoel Odorico de Moraes ◽  
Francisco Dário Rocha Filho ◽  
...  

2010 ◽  
Vol 382 (2) ◽  
pp. 139-149 ◽  
Author(s):  
Jefferson S. Oliveira ◽  
Letícia V. Costa-Lotufo ◽  
Daniel P. Bezerra ◽  
Nylane M. N. Alencar ◽  
José Delano B. Marinho-Filho ◽  
...  

2012 ◽  
Vol 48 ◽  
pp. S241
Author(s):  
D. Bezerra ◽  
A.C.A. Oliveira ◽  
A.C.S. Britto ◽  
R.M. Henriques ◽  
G.M.B. Cardoso ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Siamak Salehi ◽  
Oliver D. Tavabie ◽  
Augusto Villanueva ◽  
Julie Watson ◽  
David Darling ◽  
...  

AbstractRegulated cell proliferation is an effector mechanism of regeneration, whilst dysregulated cell proliferation is a feature of cancer. We have previously identified microRNA (miRNA) that regulate successful and failed human liver regeneration. We hypothesized that these regulators may directly modify tumor behavior. Here we show that inhibition of miRNAs -503 and -23a, alone or in combination, enhances tumor proliferation in hepatocyte and non-hepatocyte derived cancers in vitro, driving more aggressive tumor behavior in vivo. Inhibition of miRNA-152 caused induction of DNMT1, site-specific methylation with associated changes in gene expression and in vitro and in vivo growth inhibition. Enforced changes in expression of two miRNA recapitulating changes observed in failed regeneration led to complete growth inhibition of multi-lineage cancers in vivo. Our results indicate that regulation of regeneration and tumor aggressiveness are concordant and that miRNA-based inhibitors of regeneration may constitute a novel treatment strategy for human cancers.


2002 ◽  
Vol 13 (5) ◽  
pp. 533-543 ◽  
Author(s):  
Jane-Jen Wang ◽  
Yaw-Terng Chern ◽  
Yuh-Fang Chang ◽  
Tsung-Yun Liu ◽  
Chin-Wen Chi

2013 ◽  
Vol 42 (6) ◽  
pp. 2087-2093 ◽  
Author(s):  
JU-HEE HAN ◽  
JUNGLIM LEE ◽  
SOO-JIN JEON ◽  
EUN-SUN CHOI ◽  
SUNG-DAE CHO ◽  
...  

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