In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities

2011 ◽  
Vol 65 (3-4) ◽  
pp. 440-447 ◽  
Author(s):  
Yan Pan ◽  
Badrul Amini Abd-Rashid ◽  
Zakiah Ismail ◽  
Rusli Ismail ◽  
Joon Wah Mak ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Andrographis Paniculata ◽  
Hepatic Cytochrome

In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19)

2011 ◽  
Vol 133 (2) ◽  
pp. 881-887 ◽  
Author(s):  
Yan Pan ◽  
Badrul Amini Abd-Rashid ◽  
Zakiah Ismail ◽  
Rusli Ismail ◽  
Joon Wah Mak ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Centella Asiatica ◽  
Andrographis Paniculata ◽  
Orthosiphon Stamineus ◽  
Cytochrome P450 2C19

Impact of Andrographis paniculata crude extract on mouse hepatic cytochrome P450 enzymes

2006 ◽  
Vol 105 (3) ◽  
pp. 464-467 ◽  
Author(s):  
Kanokwan Jarukamjorn ◽  
Kannika Don-in ◽  
Cattaleya Makejaruskul ◽  
Thewarach Laha ◽  
Supawadee Daodee ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Crude Extract ◽  
Andrographis Paniculata ◽  
Cytochrome P450 Enzymes ◽  
Hepatic Cytochrome

Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide

2008 ◽  
Vol 115 (3) ◽  
pp. 432-440 ◽  
Author(s):  
D. Pekthong ◽  
H. Martin ◽  
C. Abadie ◽  
A. Bonet ◽  
B. Heyd ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Andrographis Paniculata ◽  
Differential Inhibition ◽  
Hepatic Cytochrome

Mechanism-based inhibition of Alantolactone on human cytochrome P450 3A4 in vitro and activity of hepatic cytochrome P450 in mice

2015 ◽  
Vol 168 ◽  
pp. 146-149 ◽  
Author(s):  
Chong-Zhen Qin ◽  
Qiao-Li Lv ◽  
Na-Yiyuan Wu ◽  
Lin Cheng ◽  
Yun-Chen Chu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 3A4 ◽  
Human Cytochrome ◽  
Hepatic Cytochrome

scholarly journals beta-Naphthoflavone abolishes interrenal sensitivity to ACTH stimulation in rainbow trout

1998 ◽  
Vol 157 (1) ◽  
pp. 63-70 ◽  
Author(s):  
JM Wilson ◽  
MM Vijayan ◽  
CJ Kennedy ◽  
GK Iwama ◽  
TW Moon
Keyword(s):  
Cytochrome P450 ◽  
Rainbow Trout ◽  
Acth Stimulation ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Treated Fish ◽  
First Time ◽  
Hepatic Cytochrome ◽  
Stimulation Of

We report for the first time that beta-naphthoflavone (BNF) abolishes ACTH stimulation of cortisol production in rainbow trout (Oncorhynchus mykiss). There was significantly higher hepatic cytochrome P450 content and ethoxyresorufin O-de-ethylase and uridine-5'-diphosphoglucuronic acid transferase activities in BNF-treated fish than in sham-treated controls. BNF did not significantly affect either plasma turnover or tissue distribution of [3H]cortisol-derived radioactivity. Hepatic membrane fluidity and hepatocyte capacity for cortisol uptake were not altered by BNF as compared with the sham-treated fish. These results taken together suggest that BNF does not affect cortisol-clearance mechanisms in trout. A 3 min handling disturbance period elicited a plasma cortisol response in the sham-treated fish; however, the response in the BNF-treated fish was muted and significantly lower than in the sham fish. This in vivo response corroborates the lack of interrenal sensitivity to ACTH in vitro in the BNF-treated fish, suggesting that BNF affects the ACTH pathway in trout. Our results suggest the possibility that cytochrome P450-inducing compounds may affect cortisol dynamics by decreasing interrenal responsiveness to ACTH stimulation in fish, thereby impairing the physiological responses that are necessary for the animal to cope with the stressor.

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