New treatment for amblyopia based on rules of synaptic plasticity: a randomized clinical trial

2022 ◽  
Author(s):  
Xin Huang ◽  
Huika Xia ◽  
Qi Zhang ◽  
Colin Blakemore ◽  
Yan Nan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Synaptic Plasticity ◽  
Randomized Clinical Trial ◽  
New Treatment

Randomized Clinical Trial Design for Assessing Noninferiority When Superiority Is Expected

2007 ◽  
Vol 25 (31) ◽  
pp. 5019-5023 ◽  
Author(s):  
Boris Freidlin ◽  
Edward L. Korn ◽  
Stephen L. George ◽  
Robert Gray
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Tolerability Profile ◽  
Modest Improvement ◽  
Noninferiority Trials ◽  
New Treatment ◽  
Formal Test ◽  
Hybrid Trial

The randomized clinical trial (RCT) is the gold standard for definitive evaluation of new therapies. RCTs designed to show that the therapeutic efficacy of a new therapy is not unacceptably inferior to that of standard therapy are called noninferiority trials. Traditionally, noninferiority trials have required very large sample sizes. Sometimes, a new treatment regimen with a favorable toxicity and/or tolerability profile is also expected to have some modest improvement in efficacy. In such specialized settings we describe a hybrid trial-design approach that requires a dramatically smaller sample size than that of a standard noninferiority design. This hybrid design can naturally incorporate a formal test of superiority as well as noninferiority.

Randomized clinical trial of LigasureTM versus open haemorrhoidectomy

2002 ◽  
Vol 89 (2) ◽  
pp. 154-157 ◽  
Author(s):  
F. F Palazzo ◽  
D. L Francis ◽  
M. A Clifton
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial

Ciprofloxacin is more effective in treating acute pouchitis than metronidazole: A randomized clinical trial

2001 ◽  
Vol 120 (5) ◽  
pp. A453-A453 ◽  
Author(s):  
B SHEN ◽  
J ACHKAR ◽  
B LASHNER ◽  
A ORMSBY ◽  
F REMZI ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial

Enhancing psychotherapy process with common factors feedback: A randomized, clinical trial.

2017 ◽  
Vol 64 (3) ◽  
pp. 247-260 ◽  
Author(s):  
Andrew S. McClintock ◽  
Matthew R. Perlman ◽  
Shannon M. McCarrick ◽  
Timothy Anderson ◽  
Lina Himawan
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Common Factors ◽  
Psychotherapy Process
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