Study on structure-activity relationship of mutation-dependent herbicide resistance acetohydroxyacid synthase through 3D-QSAR and mutation

2007 ◽  
Vol 52 (14) ◽  
pp. 1929-1941 ◽  
Author(s):  
ZhiHong Yu ◽  
CongWei Niu ◽  
ShuRong Ban ◽  
Xin Wen ◽  
Zhen Xi
Keyword(s):  
Herbicide Resistance ◽  
3D Qsar ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Acetohydroxyacid Synthase ◽  
Structure Activity ◽  
Relationship Of

scholarly journals TDPBP Derivative Aiding Liquid-Phase Synthesis Strategy and ACE Inhibitory Structure-activity Relationship of Anti-SARS Octapeptide

2020 ◽  
Author(s):  
Haidi Li ◽  
Jin Ren ◽  
Zixin Zhang ◽  
Junyou Li ◽  
Ninghui Chang ◽  
...  
Keyword(s):  
Liquid Phase ◽  
3D Qsar ◽  
Ace Inhibition ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Phase Synthesis ◽  
Fmoc Chemistry ◽  
Structure Activity ◽  
Synthesis Strategy ◽  
Relationship Of

The tri(4'-diphenylphosphonyloxylbenzoyl phenyl) phosphate (TDPBP) derivatives were designed and developed as C-terminal supports to aid the greener and highefficient liquid-phase peptide synthesis (LPPS) without the need of unrecyclable resin and chromatographic separation, whereby the anti-SARS octapeptide (2) (AVLQSGFR) was synthesized with TDPBP-OH support via Fmoc chemistry and support-aided precipitation (SAP) technology. Furthermore, the ACE inhibition and the inhibitory structure-activity relationship (SAR) between the synthetic C-terminal amidated derivate (1), anti-SARS octapeptide (2) and its alanine-scanning sequence analogues (3) to (9) were systematically studied by HPLC analysis and 3D-QSAR via molecular docking.<br>

Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking

2010 ◽  
Vol 17 (7) ◽  
pp. 1643-1659 ◽  
Author(s):  
Ping Lan ◽  
Wan-Na Chen ◽  
Zhi-Jian Huang ◽  
Ping-Hua Sun ◽  
Wei-Min Chen
Keyword(s):  
Betulinic Acid ◽  
3D Qsar ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals TDPBP Derivative Aiding Liquid-Phase Synthesis Strategy and ACE Inhibitory Structure-activity Relationship of Anti-SARS Octapeptide

2020 ◽  
Author(s):  
Haidi Li ◽  
Jin Ren ◽  
Zixin Zhang ◽  
Junyou Li ◽  
Ninghui Chang ◽  
...  
Keyword(s):  
Liquid Phase ◽  
3D Qsar ◽  
Ace Inhibition ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Phase Synthesis ◽  
Fmoc Chemistry ◽  
Structure Activity ◽  
Synthesis Strategy ◽  
Relationship Of

The tri(4'-diphenylphosphonyloxylbenzoyl phenyl) phosphate (TDPBP) derivatives were designed and developed as C-terminal supports to aid the greener and highefficient liquid-phase peptide synthesis (LPPS) without the need of unrecyclable resin and chromatographic separation, whereby the anti-SARS octapeptide (2) (AVLQSGFR) was synthesized with TDPBP-OH support via Fmoc chemistry and support-aided precipitation (SAP) technology. Furthermore, the ACE inhibition and the inhibitory structure-activity relationship (SAR) between the synthetic C-terminal amidated derivate (1), anti-SARS octapeptide (2) and its alanine-scanning sequence analogues (3) to (9) were systematically studied by HPLC analysis and 3D-QSAR via molecular docking.<br>

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Structure Activity Relationship of Kahalalide F and its Analogs Against Fusarium Spp

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
N Kasanah ◽  
AG Shilabin ◽  
DE Wedge ◽  
MT Hamann
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Fusarium Spp ◽  
Structure Activity ◽  
Kahalalide F ◽  
Relationship Of

Antineoplastic Activity, Structural Modification, Synthesis and Structure-activity Relationship of Dammarane-type Ginsenosides: An Overview

2019 ◽  
Vol 23 (5) ◽  
pp. 503-516 ◽  
Author(s):  
Qiang Zhang ◽  
Xude Wang ◽  
Liyan Lv ◽  
Guangyue Su ◽  
Yuqing Zhao
Keyword(s):  
Structural Modification ◽  
Gastrointestinal Disease ◽  
Structure Activity Relationship ◽  
Cerebrovascular Diseases ◽  
Activity Relationship ◽  
Cycle Arrest ◽  
Structure Activity ◽  
Wide Range ◽  
Structural Association ◽  
Relationship Of

Dammarane-type ginsenosides are a class of tetracyclic triterpenoids with the same dammarane skeleton. These compounds have a wide range of pharmaceutical applications for neoplasms, diabetes mellitus and other metabolic syndromes, hyperlipidemia, cardiovascular and cerebrovascular diseases, aging, neurodegenerative disease, bone disease, liver disease, kidney disease, gastrointestinal disease and other conditions. In order to develop new antineoplastic drugs, it is necessary to improve the bioactivity, solubility and bioavailability, and illuminate the mechanism of action of these compounds. A large number of ginsenosides and their derivatives have been separated from certain herbs or synthesized, and tested in various experiments, such as anti-proliferation, induction of apoptosis, cell cycle arrest and cancer-involved signaling pathways. In this review, we have summarized the progress in structural modification, shed light on the structure-activity relationship (SAR), and offered insights into biosynthesis-structural association. This review is expected to provide a preliminary guide for the modification and synthesis of ginsenosides.

Design, Facile Synthesis, Antibacterial Activity and Structure-Activity Relationship of Novel Di- and Tri-Substituted 1,3,5-Triazines

2012 ◽  
Vol 9 (3) ◽  
pp. 329-335 ◽  
Author(s):  
Surajit Kumar Ghosh ◽  
Ashmita Saha ◽  
Bornali Hazarika ◽  
Udaya Pratap Singh ◽  
Hans Raj Bhat ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Facile Synthesis ◽  
Structure Activity ◽  
Relationship Of
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