scholarly journals An Overview of the Treatment Efficacy and Side Effect Profile of Pharmacological Therapies in Asian Patients with Breast Cancer

2021 ◽  
Author(s):  
Yen-Shen Lu ◽  
Winnie Yeo ◽  
Yoon-Sim Yap ◽  
Yeon Hee Park ◽  
Kenji Tamura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Efficacy ◽  
Side Effect ◽  
Side Effect Profile ◽  
Asian Patients

Safety and Efficacy Results of a Randomized Trial Comparing Adjuvant Toremifene and Tamoxifen in Postmenopausal Patients With Node-Positive Breast Cancer

2000 ◽  
Vol 18 (20) ◽  
pp. 3487-3494 ◽  
Author(s):  
Kaija Holli ◽  
Ritva Valavaara ◽  
Guillermo Blanco ◽  
Vesa Kataja ◽  
Päivi Hietanen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effect ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Side Effect Profile ◽  
Treatment Groups ◽  
Node Positive ◽  
Er Positive ◽  
The Mean

PURPOSE: In this multicenter trial, toremifene 40 mg/d was compared with tamoxifen 20 mg/d, both given orally for 3 years to postmenopausal, axillary node–positive women after breast surgery. PATIENTS AND METHODS: The first 899 patients (toremifene, n = 459; tamoxifen, n = 440) of the total of 1,480 patients accrued to the trial were included in this scheduled safety analysis. The mean follow-up time was 3.4 years. RESULTS: The two treatment groups were well balanced with respect to patient and disease characteristics. The subjective side-effect profile was similar in both treatment groups. Slightly more vascular complications (deep vein thromboses, cerebrovascular events, and pulmonary embolisms) were seen among tamoxifen-treated patients (5.9%) as compared with toremifene-treated patients (3.5%) (P = .11), whereas bone fractures (P = .09) and vaginal leukorrhea (P = .05) were more common in the toremifene group. The number of subsequent second cancers was similar. The breast cancer recurrence rate was 23.1% (n = 106) in the toremifene group and 26.1% (n = 115) in the tamoxifen group (P = .31). When only patients with estrogen receptor (ER)–positive cancer were considered (n = 556), the risk for breast cancer recurrence was nonsignificantly lower among the toremifene-treated women, with a hazards ratio of 0.74 (90% confidence interval, 0.52 to 1.04; P = .14). The mean time to breast cancer recurrence and overall survival were similar in both groups. CONCLUSION: The side-effect profile of toremifene resembles that of tamoxifen. The efficacy of toremifene seems to be no less than that of tamoxifen. The trend for fewer breast cancer recurrences in the ER-positive subgroup is encouraging, but a longer follow-up is needed to confirm this.

Ropinirole, a potential drug for systematic repositioning based on side effect profile for management and treatment of breast cancer

2020 ◽  
Vol 144 ◽  
pp. 110156 ◽  
Author(s):  
Emdormi Rymbai ◽  
Deepa Sugumar ◽  
J. Saravanan ◽  
S. Divakar
Keyword(s):  
Breast Cancer ◽  
Side Effect ◽  
Side Effect Profile ◽  
Potential Drug

Treatment of Febrile Seizures: The Influence of Treatment Efficacy and Side-Effect Profile on Value to Parents

PEDIATRICS ◽  
2001 ◽  
Vol 108 (5) ◽  
pp. 1080-1088 ◽  
Author(s):  
K. E. Gordon ◽  
J. M. Dooley ◽  
P. R. Camfield ◽  
C. S. Camfield ◽  
J. MacSween
Keyword(s):  
Treatment Efficacy ◽  
Side Effect ◽  
Febrile Seizures ◽  
Side Effect Profile

Everolimus: side effect profile and management of toxicities in breast cancer

2013 ◽  
Vol 140 (3) ◽  
pp. 453-462 ◽  
Author(s):  
Elisavet Paplomata ◽  
Amelia Zelnak ◽  
Ruth O’Regan
Keyword(s):  
Breast Cancer ◽  
Side Effect ◽  
Side Effect Profile

Valproic Acid:

1999 ◽  
Vol 16 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Sayonara Beatriz Ranciaro Fagundes
Keyword(s):  
Health Care ◽  
Valproic Acid ◽  
Antiepileptic Drug ◽  
Detailed Analysis ◽  
Side Effect ◽  
Side Effect Profile ◽  
Care Givers

Clinical pharmacologists, neurologists, and all health care givers must consider the efficacy, safety, and side effect profile of a given antiepileptic drug when determining which drug is best for a given patient.The purpose of this study was to investigate valproic acid with a detailed analysis of the different reports.

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