Spontaneous brain activity in mild cognitive impairment revealed by amplitude of low-frequency fluctuation analysis: a resting-state fMRI study

2012 ◽  
Vol 117 (5) ◽  
pp. 865-871 ◽  
Author(s):  
Q. Xi ◽  
X. Zhao ◽  
P. Wang ◽  
Q. Guo ◽  
H. Jiang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Resting State ◽  
Brain Activity ◽  
Low Frequency ◽  
Resting State Fmri ◽  
Frequency Fluctuation ◽  
Fluctuation Analysis ◽  
Spontaneous Brain Activity ◽  
Fmri Study

scholarly journals Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Lv Han ◽  
Liu Zhaohui ◽  
Yan Fei ◽  
Li Ting ◽  
Zhao Pengfei ◽  
...  
Keyword(s):  
Resting State ◽  
Structural Changes ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Resting State Fmri ◽  
Pulsatile Tinnitus ◽  
Spontaneous Brain Activity ◽  
Fmri Study ◽  
The Brain

Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n=42) and age-, sex-, and education-matched normal control subjects (n=42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.

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