Backround:
Radiation induced oral mucositis consists of a series of relatively frequent side effects after head
and neck cancer radiotherapy and has an adverse impact on both regular treatment process and the quality of life of patients.
Objective:
The purpose of the present review is to optimize the current management of radiation induced oral mucositis in
head and neck cancer patients.
Methods:
PubMed database research was performed on articles published since 2015 that demonstrated efficacy in the
management of radiation induced oral mucositis in head and neck cancer patients.The study selection included observa-tional, prospective, comparative, randomized, double-blind, placebo-controlled or uncontrolled, and retrospective studies,
as well as systematic reviews and metanalyses.
Results:
From the 931 citations of our search only 94 articles met our inclusion criteria including mucosal protectants, anti-inflammatory agents, growth factors, and various miscellaneous and natural agents. Several methods including both
pharmacological and natural agents have been proposed for the management of oral mucositis. In addition to the already
known interventions with high evidence, according to Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology guidelines, further agents have been used. However, a great number of them are lacking of clear evidence, which surely requires the design of more controlled clinical trials for the better assessment of the
most ideal methods.
Conclusion:
The management of oral mucositis constitutes an active area of research. In the light of our results we aim to
illustrate those treatment strategies that are most effective regarding the treatment approach of oral mucositis.