Risk analysis of hepatocellular carcinoma in Northeast China

2009 ◽  
Vol 21 (4) ◽  
pp. 304-309
Author(s):  
Zhi-fang Jia ◽  
Meng Su ◽  
Miao He ◽  
Zhi-hua Yin ◽  
Wei Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Analysis ◽  
Northeast China

scholarly journals A Scoring System For Predicting Hepatocellular Carcinoma Risk In Alcoholic Cirrhosis: A Competing Risk Analysis

2021 ◽  
Author(s):  
Kyunghan Lee ◽  
Gwang Hyeon Choi ◽  
Eun Sun Jang ◽  
Sook-Hyang Jeong ◽  
Jin–Wook Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Analysis ◽  
Viral Hepatitis ◽  
Validation Cohort ◽  
Alcoholic Cirrhosis ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
Hazards Model ◽  
B Virus

Abstract Background & Aims: The role of hepatocellular carcinoma (HCC) surveillance is being questioned in alcoholic cirrhosis because of the relative low HCC risk. Comorbid viral hepatitis may synergistically increase the HCC risk in alcoholic cirrhosis. This study aimed to assess the risk and predictors of HCC in patients with alcoholic cirrhosis by using competing risk analysis in an area with intermediate prevalence for hepatitis B virus.Methods: A total of 965 patients with alcoholic cirrhosis were recruited at a university-affiliated hospital in Korea and randomly assigned to either the derivation (n=643) and validation (n=322) cohort. Subdistribution hazards model of Fine and Gray was used with deaths and liver transplantation treated as competing risks. Death records were confirmed from Korean government databases. A nomogram was developed to calculate the Alcohol-associated Liver Cancer Estimation (ALICE) score.Results: Markers for viral hepatitis were positive in 21.0 % and 25.8 % of patients in derivation and validation cohort, respectively. The cumulative incidence of HCC was 13.5 and 14.9 % at 10 years for derivation and validation cohort, respectively. Age, positivity for viral hepatitis markers, alpha-fetoprotein level, and platelet count were identified as independent predictors of HCC and incorporated in the ALICE score, which discriminated low, intermediate, and high risk for HCC in alcoholic cirrhosis at the cut-off of 120 and 180. Conclusions: HCC risk can be stratified by using clinical parameters including viral markers in alcoholic cirrhosis in an area where the prevalence of viral hepatitis is substantial.

scholarly journals Radionuclide content and risk analysis of edible mushrooms in northeast China

2021 ◽  
Author(s):  
Shuo Wang ◽  
Baolu Yang ◽  
Qiang Zhou ◽  
Zeshu Li ◽  
Wenhong Li ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Northeast China ◽  
Edible Mushrooms ◽  
Radionuclide Content

Polymorphisms of UGT1A7 and XRCC1 are associated with an increased risk of hepatocellular carcinoma in Northeast China

2010 ◽  
Vol 22 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Zhi-fang Jia ◽  
Hong-ying Su ◽  
Xue-lian Li ◽  
Xin Xu ◽  
Zhi-hua Yin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Northeast China ◽  
Increased Risk

scholarly journals Risk Prediction of Hepatocellular Carcinoma in Patients With Alcoholic Cirrhosis in an Area With Intermediate Prevalence for Hepatitis B Virus Infection: a Competing Risk Analysis

2021 ◽  
Author(s):  
Kyunghan Lee ◽  
Gwang Hyeon Choi ◽  
Eun Sun Jang ◽  
Sook-Hyang Jeong ◽  
Jin-Wook Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Risk Analysis ◽  
Viral Hepatitis ◽  
Validation Cohort ◽  
Alcoholic Cirrhosis ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
B Virus

Abstract Background & Aims: The role of hepatocellular carcinoma (HCC) surveillance is being questioned in alcoholic cirrhosis because of the relative low incidence of HCC. Comorbid viral hepatitis may modify the risk, and competing outcomes may influence the actual incidence of HCC in alcoholic cirrhosis. This study aimed to assess the risk and predictors of HCC in patients with alcoholic cirrhosis by using competing risk analysis in an area with intermediate prevalence for hepatitis B virus.Methods: A total of 965 patients with alcoholic cirrhosis were recruited at a university-affiliated hospital in Korea and randomly assigned to either the derivation (n=643) and validation (n=322) cohort. Subdistribution hazards model of Fine and Gray was used with deaths and liver transplantation treated as competing risks. Death records were confirmed from Korean government databases. A nomogram was developed to calculate the Alcohol-associated Liver Cancer Estimation (ALICE) score.Results: Markers for viral hepatitis were positive in 21.0 % and 25.8 % of patients in derivation and validation cohort, respectively. The cumulative incidence of HCC was 13.5 and 14.9 % at 10 years for derivation and validation cohort, respectively. Age, positivity for viral hepatitis markers, alpha-fetoprotein level, and platelet count were identified as independent predictors of HCC and incorporated in the ALICE score, which discriminated low, intermediate, and high risk for HCC in alcoholic cirrhosis at the cut-off of 120 and 180. Conclusions: ALICE score reliably stratifies HCC risk of alcoholic cirrhosis in an area where the prevalence of viral hepatitis is substantial.

Risk analysis of climate variability on food production in Hailun, Northeast China

2010 ◽  
Vol 18 (6) ◽  
pp. 1345-1350
Author(s):  
Hai-Ping ZHANG ◽  
Li-Ding CHEN ◽  
Xiao-Yan WANG ◽  
Yan MA ◽  
Xin-Feng ZHAO ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Climate Variability ◽  
Northeast China ◽  
Food Production

scholarly journals The Effect of SNPs in lncRNA As ceRNA on the Risk and Prognosis of Hepatocellular Carcinoma

2021 ◽  
Author(s):  
Han Mo ◽  
Xi Wang ◽  
Guohua Ji ◽  
Xiao Liang ◽  
Yi Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Genetic Risk ◽  
Northeast China ◽  
Clinical Characteristics ◽  
Healthy Controls ◽  
Interindividual Differences ◽  
Han Population ◽  
Coding Regions ◽  
Stratified Analysis ◽  
The Relationship

Abstract Background: Most the HCC susceptible loci identified by GWAS are located in non-coding regions, and the mechanism of action remains unclear. The objective of this study was to explore the relationship among SNPs on lncRNA that affects ceRNA mechanism and the risk and prognosis of HCC.Methods: Combined with multiple databases, eight lncRNA genes that affect HCC were systematically screened through the mechanism of lncRNA-mediated ceRNA, and 15 SNPs that affect miRNA binding in the eight lncRNA genes were annotated. Genotyping was conducted in 800 HCC cases and 801 healthy controls from a Han population in Northeast China to examine the genetic risk associated with HCC.Results: The GG, GC and GG + GC genotypes of HOTAIR rs7958904 were found to be associated with a 0.65, 0.59 and 0.63-fold decreased HCC risk, respectively. Moreover, in the stratified analysis of clinical characteristics and biochemical indexes, HCC patients with PVT1 rs3931282 AA + GA genotypes were less prone to develop late-stage tumors; rs1134492 and rs10589312 in PVT1 and rs84557 in EGFR-AS1 showed significant associations with AST, ALT or AST/ALT ratio. Conclusions: The results provide new insights of how non-coding loci confer the interindividual differences to susceptibility and progression of HCC.

scholarly journals Competing risk analysis on outcome after hepatic resection of hepatocellular carcinoma in cirrhotic patients

2017 ◽  
Vol 23 (8) ◽  
pp. 1469 ◽  
Author(s):  
Alessandro Cucchetti ◽  
Carlo Sposito ◽  
Antonio Daniele Pinna ◽  
Davide Citterio ◽  
Matteo Cescon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Analysis ◽  
Hepatic Resection ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
Cirrhotic Patients
Sign in / Sign up

Export Citation Format

Share Document