Altered modular organization of intrinsic brain functional networks in patients with Parkinson’s disease

2016 ◽  
Vol 11 (2) ◽  
pp. 430-443 ◽  
Author(s):  
Qing Ma ◽  
Biao Huang ◽  
Jinhui Wang ◽  
Carol Seger ◽  
Wanqun Yang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Modular Organization ◽  
Functional Networks ◽  
Brain Functional Networks

scholarly journals Alteration of Brain Functional Networks in Early-Stage Parkinson’s Disease: A Resting-State fMRI Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141815 ◽  
Author(s):  
Linqiong Sang ◽  
Jiuquan Zhang ◽  
Li Wang ◽  
Jingna Zhang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Resting State ◽  
Early Stage ◽  
Resting State Fmri ◽  
Functional Networks ◽  
Brain Functional Networks ◽  
Fmri Study

Prefrontal activity imbalance and aberrant reconfiguration across functional networks in patients with Parkinson's disease and somatic symptom disorder

2021 ◽  
Vol 429 ◽  
pp. 119498
Author(s):  
Stefano Delli Pizzi ◽  
Raffaella Franciotti ◽  
Piero Chiacchiaretta ◽  
Antonio Ferretti ◽  
Astrid Thomas ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Somatic Symptom ◽  
Functional Networks ◽  
Somatic Symptom Disorder

Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease

NeuroImage ◽  
2015 ◽  
Vol 119 ◽  
pp. 296-304 ◽  
Author(s):  
Jee Hyun Ham ◽  
Jungho Cha ◽  
Jae Jung Lee ◽  
Gwang-Min Baek ◽  
Mun Kyung Sunwoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Resting State ◽  
Functional Networks ◽  
Nigrostriatal Dopamine

Patterns of olfactory functional networks in Parkinson's disease dementia and Alzheimer's dementia

2020 ◽  
Vol 89 ◽  
pp. 63-70 ◽  
Author(s):  
Yang Hyun Lee ◽  
Yunjin Bak ◽  
Chang-hyun Park ◽  
Seok Jong Chung ◽  
Han Soo Yoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Alzheimer’S Dementia ◽  
Functional Networks ◽  
Parkinson’S Disease Dementia ◽  
Alzheimer's Dementia

Distinct Effects of Motor Training on Resting-State Functional Networks of the Brain in Parkinson’s Disease

2020 ◽  
Vol 34 (9) ◽  
pp. 795-803
Author(s):  
Amgad Droby ◽  
Inbal Maidan ◽  
Yael Jacob ◽  
Nir Giladi ◽  
Jeffrey M. Hausdorff ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neural Plasticity ◽  
Resting State ◽  
Large Scale ◽  
Functional Networks ◽  
Motor Training ◽  
Neural Pathways ◽  
Precentral Gyrus ◽  
Sensorimotor Network

Background. Nigrostriatal dopaminergic loss is a hallmark of Parkinson’s disease (PD) pathophysiology, leading to motor Parkinsonism. Different intervention protocols have shown that motor and cognitive functions improvement in PD occur via the modulation of distinct motor and cognitive pathways. Objective. To investigate the effects of two motor training programs on the brains’ functional networks in PD patients. Methods. Thirty-seven PD patients were prospectively studied. All enrolled patients underwent either treadmill training (TT) (n = 19) or treadmill with virtual reality (TT + VR) (n = 18) for 6 weeks. Magnetic resonance imaging (MRI) scans (3 T) acquiring 3-dimensional T1-weighted and resting-state functional MRI (rs-fMRI) data sets were performed at baseline and after 6 weeks. Independent component analysis (ICA) was conducted, and functional connectivity (FC) changes within large-scale functional brain networks were examined. Results. In both groups, significant post-training FC decrease in striatal, limbic, and parietal regions within the basal ganglia network, executive control network, and frontal-striatal network, and significant FC increase in the caudate, and cingulate within the sensorimotor network (SMN) were observed. Moreover, a significant time × group interaction was detected where TT + VR training had greater effects on FC levels in the supplementary motor area (SMA) and right precentral gyrus within the SMN, and in the right middle frontal gyrus (MFG) within the cerebellar network. These FC alterations were associated with improved usual and dual-task walking performance. Conclusions. These results suggest that TT with-and-without the addition of a VR component affects distinct neural pathways, highlighting the potential for beneficial neural plasticity in PD. Such distinctive task-specific pathways may foster the facilitation of interventions tailored to the individual needs of PD patients. Registered at Clinicaltrials.gov number: NCT01732653.

Gender-specific effect of uric acid on resting-state functional networks in de novo Parkinson's disease

2018 ◽  
Vol 52 ◽  
pp. 49-54 ◽  
Author(s):  
Yoonju Lee ◽  
Yeong-Hun Park ◽  
Jae Jung Lee ◽  
Young H. Sohn ◽  
Jong-Min Lee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Uric Acid ◽  
Resting State ◽  
De Novo ◽  
Specific Effect ◽  
Functional Networks ◽  
Gender Specific

Age-related changes in modular organization of human brain functional networks

NeuroImage ◽  
2009 ◽  
Vol 44 (3) ◽  
pp. 715-723 ◽  
Author(s):  
David Meunier ◽  
Sophie Achard ◽  
Alexa Morcom ◽  
Ed Bullmore
Keyword(s):  
Human Brain ◽  
Modular Organization ◽  
Functional Networks ◽  
Brain Functional Networks ◽  
Age Related ◽  
Age Related Changes

scholarly journals Functional networks in motor sequence learning: Abnormal topographies in Parkinson's disease

2000 ◽  
Vol 12 (1) ◽  
pp. 42-60 ◽  
Author(s):  
T. Nakamura ◽  
M.F. Ghilardi ◽  
M. Mentis ◽  
V. Dhawan ◽  
M. Fukuda ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sequence Learning ◽  
Functional Networks ◽  
Motor Sequence Learning ◽  
Motor Sequence
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