A label-free electrochemical immunosensor based on multi-functionalized graphene oxide for ultrasensitive detection of microcystin-LR

2017 ◽  
Vol 72 (1) ◽  
pp. 71-79 ◽  
Author(s):  
YunXia Hu ◽  
Fang Shang ◽  
Yuan Liu ◽  
Sui Wang ◽  
Yufang Hu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Electrochemical Immunosensor ◽  
Ultrasensitive Detection ◽  
Functionalized Graphene ◽  
Label Free ◽  
Functionalized Graphene Oxide

Label-free electrochemical immunosensor based on gold nanoparticle/polyethyleneimine/reduced graphene oxide nanocomposite for the ultrasensitive detection of cancer biomarker matrix metalloproteinase-1

The Analyst ◽  
2021 ◽  
Author(s):  
Xinke Liu ◽  
Lu-Yin Lin ◽  
Fu-Yen Tseng ◽  
Yu-Cheng Tan ◽  
Jian Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Matrix Metalloproteinase ◽  
Gold Nanoparticle ◽  
Reduced Graphene Oxide ◽  
Electrochemical Immunosensor ◽  
Ultrasensitive Detection ◽  
Label Free ◽  
Matrix Metalloproteinase 1 ◽  
Reduced Graphene ◽  
P Matrix

Matrix metalloproteinase-1 (MMP-1) is associated with many types of cancers, including oral, colorectal, and brain cancers. This paper describes the fabrication of an MMP-1 immunosensor based on a gold nanoparticle/polyethyleneimine/reduced...

scholarly journals New Ultrasensitive Sandwich-Type Immunoassay of Dendritic Tri-Fan Blade-like PdAuCu Nanoparticles/Amine-Functionalized Graphene Oxide for Label-Free Detection of Carcinoembryonic Antigen

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1256
Author(s):  
Pingping Xu ◽  
Wenpo Feng ◽  
Mei Wang ◽  
Ling Zhang ◽  
Gaofeng Liang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Carcinoembryonic Antigen ◽  
Au Nanoparticle ◽  
Functionalized Graphene ◽  
Label Free ◽  
Functionalized Graphene Oxide ◽  
Amine Functionalized ◽  
Label Free Detection ◽  
Sandwich Type ◽  
Fan Blade

The early detection of tumor markers has an effective role in the treatment of cancer. Here, a new sandwich-type electrochemical immunosensor for early label-free detection of the cancer biomarker carcinoembryonic antigen (CEA) was developed. Dendritic tri-fan blade-like PdAuCu nanoparticles (PdAuCu NPs)/amine functionalized graphene oxide (NH2-GO) were the label of secondary antibodies (Ab2), and Au nanoparticle-decorated polydopamines (Au/PDA) were immobilized on a screen-printed carbon electrode (SPCE) as the substrate materials. Dendritic tri-fan blade-like PdAuCu NPs/NH2-GO was synthesized according to a simple hydrothermal procedure and used to immobilize antibodies (Ab2) with large surfaces areas, increased catalytic properties and good adsorption to amplify the current signals. Subsequently, Ab2/PdAuCu NPs/NH2-GO catalyzed the reduction of H2O2 in the sandwich-type immunoreactions. Under optimal conditions, the immunosensor exhibited a satisfactory response to CEA with a limit detection of 0.07 pg mL−1 and a linear detection range from 0.1 pg mL−1 to 200 ng mL−1. The proposed immunosensor could be suitable enough for a real sample analysis of CEA, and has clinical value in the early diagnosis of cancer.

scholarly journals A label-free immunosensor based on PHEMA/graphene oxide nanocomposite for simultaneous electrochemical determination of alpha fetoprotein

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17187-17193 ◽  
Author(s):  
Ying Liang ◽  
Xiaoqing Zhao ◽  
Na Wang ◽  
Jing Wang ◽  
Hou Chen ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Electrochemical Determination ◽  
Electrochemical Immunosensor ◽  
Alpha Fetoprotein ◽  
Ultrasensitive Detection ◽  
Hydroxyethyl Methacrylate ◽  
Label Free

An electrochemical immunosensor based on poly(2-hydroxyethyl methacrylate) (PHEMA)/graphene oxide (GO) nanocomposite was designed in a simple way for the ultrasensitive detection of tumor makers (alpha-fetoprotein, AFP as a model).

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