The Role of Bariatric Surgery in the Treatment of Type 2 Diabetes: Current Evidence and Clinical Guidelines

2013 ◽  
Vol 15 (11) ◽  
Author(s):  
Michael A. Via ◽  
Jeffrey I. Mechanick
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Clinical Guidelines ◽  
Current Evidence

scholarly journals Gut as an emerging organ for the treatment of diabetes: focus on mechanism of action of bariatric and endoscopic interventions

2018 ◽  
Vol 237 (1) ◽  
pp. R1-R17 ◽  
Author(s):  
Martin Haluzík ◽  
Helena Kratochvílová ◽  
Denisa Haluzíková ◽  
Miloš Mráz
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Therapeutic Option ◽  
Gastrointestinal Hormones ◽  
Less Invasive ◽  
Treatment Of Diabetes ◽  
Endoscopic Methods ◽  
Diabetes And Obesity

Increasing worldwide prevalence of type 2 diabetes mellitus and its accompanying pathologies such as obesity, arterial hypertension and dyslipidemia represents one of the most important challenges of current medicine. Despite intensive efforts, high percentage of patients with type 2 diabetes does not achieve treatment goals and struggle with increasing body weight and poor glucose control. While novel classes of antidiabetic medications such as incretin-based therapies and gliflozins have some favorable characteristics compared to older antidiabetics, the only therapeutic option shown to substantially modify the progression of diabetes or to achieve its remission is bariatric surgery. Its efficacy in the treatment of diabetes is well established, but the exact underlying modes of action are still only partially described. They include restriction of food amount, enhanced passage of chymus into distal part of small intestine with subsequent modification of gastrointestinal hormones and bile acids secretion, neural mechanisms, changes in gut microbiota and many other possible mechanisms underscoring the importance of the gut in the regulation of glucose metabolism. In addition to bariatric surgery, less-invasive endoscopic methods based on the principles of bariatric surgery were introduced and showed promising results. This review highlights the role of the intestine in the regulation of glucose homeostasis focusing on the mechanisms of action of bariatric and especially endoscopic methods of the treatment of diabetes. A better understanding of these mechanisms may lead to less invasive endoscopic treatments of diabetes and obesity that may complement and widen current therapeutic options.

scholarly journals Role of gut microbiota, bile acids and their cross-talk in the effects of bariatric surgery on obesity and type 2 diabetes

2017 ◽  
Vol 9 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Haijun Liu ◽  
Cheng Hu ◽  
Xueli Zhang ◽  
Weiping Jia
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Cross Talk

scholarly journals Remission of type 2 diabetes in obese patients after bariatric surgery: the role of incretins

2010 ◽  
Vol 18 (4) ◽  
pp. 324
Author(s):  
Wen-Fang Hou ◽  
Guo-Qiang Liu ◽  
Tian-Pei Hong
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Obese Patients

Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of type 2 diabetes

2011 ◽  
Vol 14 (4) ◽  
pp. 291-298 ◽  
Author(s):  
N. A. Rhee ◽  
T. Vilsbøll ◽  
F. K. Knop
Keyword(s):  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Current Evidence

scholarly journals New glance at pathogenesis of type 2 diabetes mellitus: incretin and antiincretin systems.

2011 ◽  
Vol 14 (3) ◽  
pp. 26-29 ◽  
Author(s):  
Ekaterina Alekseevna Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Gastrointestinal Tract ◽  
Glycemic Status ◽  
Decrease Body Weight

Type 2 diabetes mellitus (T2 DM) is often seen in patients with obesity. Bariatric surgery, aimed to decrease body weight, can often help those patientsto improve glycemic status. After some of bariatric operations patients reach normoglycemia in few days, the fact that cant be explained onlyby reduction in weight. Recent trials revealed that the reorganization of gastrointestinal tract provides hypoglycemic effect of such operations. Thisarticle explains the role of proximal and distal gut in pathophysiology of T2 DM.

Sign in / Sign up

Export Citation Format

Share Document