Circulating Tumor Cells: State-of-the-art Update on Technologies and Clinical Applications

2019 ◽  
Vol 14 (5) ◽  
pp. 353-357 ◽  
Author(s):  
Kristofor Yap ◽  
Evan N. Cohen ◽  
James M. Reuben ◽  
Joseph D. Khoury
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
State Of The Art ◽  
Clinical Applications

Clinical Applications of Circulating Tumor Cells in Breast Cancer

2019 ◽  
pp. 147-160 ◽  
Author(s):  
Erin F. Cobain ◽  
Costanza Paoletti ◽  
Jeffrey B. Smerage ◽  
Daniel F. Hayes
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Clinical Applications

scholarly journals Circulating Tumor Cells in Metastatic Breast Cancer: Clinical Applications and Future Possibilities

2020 ◽  
Vol 10 (9) ◽  
pp. 3311
Author(s):  
Maggie Banys-Paluchowski ◽  
Florian Reinhardt ◽  
Tanja Fehm
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Therapy Monitoring ◽  
Metastatic Breast ◽  
Study Groups ◽  
Clinical Applications ◽  
Response To Treatment ◽  
Cellsearch System

Circulating tumor cells (CTCs) have gained importance as an emerging biomarker in solid tumors in the last two decades. Several detection assays have been introduced by various study groups, with EpCAM-based CellSearch system being the most widely used and standardized technique. In breast cancer, detection of CTCs correlates with clinical outcome in early and metastatic settings. CTC persistence beyond first cycle of palliative chemotherapy indicates poor response to treatment in metastatic situation. Beyond prognostication and therapy monitoring, CTC counts can guide treatment decisions in hormone receptor positive HER2-negative metastatic breast cancer. Furthermore, CTC-based therapy interventions are currently under investigation in clinical trials. In this review, we focus on the current state of knowledge and possible clinical applications of CTC diagnostics in patients with metastatic breast cancer.

Liquid biopsy: novel technologies and clinical applications

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Natalie Reimers ◽  
Klaus Pantel
Keyword(s):  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Peripheral Blood ◽  
Liquid Biopsy ◽  
Clinical Applications ◽  
Novel Technologies ◽  
The Past

Abstract“Liquid biopsy” was introduced as a new diagnostic concept in 2010 for the analysis of circulating tumor cells (CTCs) and has been now extended to material (in particular DNA) released by tumor cells in the peripheral blood of cancer patients. Over the past decade, various methods have been developed to detect CTCs and ctDNA in the peripheral blood of cancer patients.

scholarly journals Circulating tumor cells: Advances in isolation and analysis, and challenges for clinical applications

2014 ◽  
Vol 141 (2) ◽  
pp. 209-221 ◽  
Author(s):  
Ramdane Harouaka ◽  
Zhigang Kang ◽  
Si-Yang Zheng ◽  
Liang Cao
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Clinical Applications
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