Challenges and Opportunities in Multimodal Monitoring and Data Analytics in Traumatic Brain Injury

Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population; however, research in this population lags behind research in adults. This may be due, in part, to the smaller number of investigators engaged in research with this population and may also be related to changes in safety laws and clinical practice that have altered length of hospital stays, treatment, and access to this population. Specific developmental issues also warrant attention in studies of children, and the ever-changing context of childhood and adolescence may require larger sample sizes than are commonly available to adequately address remaining questions related to TBI. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric Moderate-Severe TBI (msTBI) group aims to advance research in this area through global collaborative meta-analysis. In this paper we discuss important challenges in pediatric TBI research and opportunities that we believe the ENIGMA Pediatric msTBI group can provide to address them. We conclude with recommendations for future research in this field of study.

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Multimodal monitoring in traumatic brain injury: current status and future directions

British Journal of Anaesthesia ◽

10.1093/bja/aem143 ◽

2007 ◽

Vol 99 (1) ◽

pp. 61-67 ◽

Cited By ~ 85

Author(s):

M.M. Tisdall ◽

M. Smith

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Current Status ◽

Future Directions ◽

Multimodal Monitoring

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Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines

10.31234/osf.io/d4qs8 ◽

2019 ◽

Cited By ~ 2

Author(s):

David F Tate ◽

Emily L. Dennis ◽

John T Adams ◽

Maheen Adamson ◽

Heather G Belanger ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Meta Analysis ◽

Natural Aging ◽

Prognostic Accuracy ◽

Challenges And Opportunities ◽

Imaging Markers ◽

Conducting Research ◽

Return To Duty ◽

Neuroimaging Genetics

Traumatic brain injury (TBI) is common among military personnel and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. This inconsistent presentation makes it difficult to establish or validate biological and imaging markers that could help improve diagnostic and prognostic accuracy in this patient population. The purpose of this manuscript is to describe both the challenges and opportunities when conducting research with Service Members and Veterans and introduce the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Military Brain Injury working group. ENIGMA is a worldwide consortium focused on improving replicability and analytical power through data sharing and collaboration. In this paper, we discuss challenges affecting efforts to aggregate data in this patient group. In addition, we highlight how “big data” approaches might be used to understand better the role that each of these variables might play in the imaging and functional phenotypes of TBI in Service Member and Veteran populations, and how data may be used to examine important military specific issues such as return to duty, the late effects of combat-related injury, and alteration of the natural aging processes.

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Bioengineering in Brain Trauma Research

Neurotrauma ◽

10.1093/med/9780190279431.003.0028 ◽

2018 ◽

pp. 347-358

Author(s):

Michelle C. LaPlaca

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Problem Solving ◽

Injury Prevention ◽

Data Analytics ◽

Imaging Biomarkers ◽

Injury Biomechanics ◽

Problem Solving Skills ◽

Trauma Research ◽

Quantitative Analyses

The study of traumatic brain injury (TBI) encompasses research spanning from injury prevention to clinical interventions, all of which have been influenced by bioengineering. Bioengineering uses quantitative analyses and problem-solving skills to approach the complexity of many areas of neurotrauma research including injury biomechanics, imaging, biomarkers, and data analytics. This chapter presents basic bioengineering concepts, highlights significant contributions to neurotrauma research, and discusses opportunities in the field that may lend themselves to bioengineering solutions. The intention of the author is to promote an appreciation of engineering and to catalyze problem-solving among readers, engineers and non-engineers alike.

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