Mechanism of Action of Peripheral Nerve Stimulation

2021 ◽  
Vol 25 (7) ◽  
Author(s):  
Natalie H. Strand ◽  
Ryan D’Souza ◽  
Christopher Wie ◽  
Stephen Covington ◽  
Moustafa Maita ◽  
...  
Biomedicines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 18
Author(s):  
Alaa Abd-Elsayed ◽  
Ryan S. D’Souza

Peripheral nerve stimulation (PNS) involves the application of electrical stimulation near the proximity of peripheral nerves. Although the mechanism of action remains unknown, PNS likely modulates both the central and peripheral nervous systems to provide analgesia for a wide variety of pain disorders involving the head, extremities, and trunk. Historically, PNS was not utilized widely due to underwhelming results from earlier studies. However, significant innovations in device technologies, including improved implantation techniques, hardware miniaturization, and externalized pulse generators, have led to the resurgence of PNS in the field of pain medicine. This editorial briefly reviews the evolution of PNS in the field of pain medicine and highlights areas for future investigation.


2021 ◽  
pp. 2004033
Author(s):  
Estelle A. Cuttaz ◽  
Christopher A. R. Chapman ◽  
Omaer Syed ◽  
Josef A. Goding ◽  
Rylie A. Green

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