Evaluation of 90-day Repeated Dose Oral Toxicity, Glycometabolism, Learning and Memory Ability, and Related Enzyme of Chromium Malate Supplementation in Sprague-Dawley Rats

2015 ◽  
Vol 168 (1) ◽  
pp. 181-195 ◽  
Author(s):  
Weiwei Feng ◽  
Huiyu Wu ◽  
Qian Li ◽  
Zhaoxiang Zhou ◽  
Yao Chen ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Memory Ability ◽  
Sprague Dawley Rats ◽  
Dose Oral ◽  
Related Enzyme ◽  
Chromium Malate

4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats

2016 ◽  
Vol 81 ◽  
pp. 275-283 ◽  
Author(s):  
A.M. Saillenfait ◽  
F. Marquet ◽  
J.P. Sabaté ◽  
D. Ndiaye ◽  
A.M. Lambert-Xolin
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

scholarly journals A 4-Week Repeated-Dose Oral Toxicity Study of Bojungikgi-Tang in Crl:CD Sprague Dawley Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Sae-Rom Yoo ◽  
Hyekyung Ha ◽  
Mee-Young Lee ◽  
Hyeun-Kyoo Shin ◽  
Su-Cheol Han ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Serum Biochemistry ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Organ Weights ◽  
Sprague Dawley Rats ◽  
Dose Oral

Traditional herbal medicines have been used for centuries in Asian countries. However, recent studies have led to increasing concerns about the safety and toxicity of herbal prescriptions. Bojungikgi-tang (BJIGT), a herbal decoction, has been used in Korea to improve physical strength. To establish the safety information, BJIGT water extract was evaluated in a 4-week repeated-dose oral toxicity test in Crl:CD Sprague Dawley rats. BJIGT was orally administered in daily doses of 0, 500, 1000, and 2000 mg/kg/day for 4 weeks via oral gavage in male and female rats. We examined the mortality, clinical signs, body weight change, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters. No significant changes were observed in mortality, clinical sings, body weight, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters between the control group and the BJIGT-treated groups in the rats of both sexes. The results indicate that BJIGT did not induce toxic effects at a dose level up to 2000 mg/kg in rats. Thus, this concentration is considered the nonobservable effect dose in rats and is appropriate for a 13-week subchronic toxicity study.

200 Repeated dose oral toxicity (13 weeks) of 4-hydroxy-3-methoxy-benzaldehyde (vanillin) to sprague dawley rats

2003 ◽  
Vol 144 ◽  
pp. s57 ◽  
Author(s):  
Axel Mancebo ◽  
Yoagne M. Trapero ◽  
Yana González ◽  
Bárbara O. Gonzalez ◽  
Dasha Fuentes ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

scholarly journals A 28 Day Repeated Dose-Oral Toxicity Studies of Arisaema Rhizome Aqueous Extracts in Sprague-Dawley Rats

2015 ◽  
Vol 28 (4) ◽  
pp. 371-381
Author(s):  
Min-Kyeoung Kim ◽  
Ji Sun Lee ◽  
Yeong Chul Park ◽  
Sun Mi Choi ◽  
Sanghun Lee
Keyword(s):  
Repeated Dose ◽  
Aqueous Extracts ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Sprague Dawley Rats ◽  
Dose Oral

A 14-day Repeated Dose Oral Toxicity Study of HT042 in Sprague-Dawley Rats

2017 ◽  
Vol 32 (1) ◽  
pp. 63-68
Author(s):  
Jungbin Song ◽  
Donghun Lee ◽  
Young-Sik Kim ◽  
Seunggyeong Lee ◽  
Jin-Sook Bae ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

scholarly journals A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test

2015 ◽  
Vol 18 (4) ◽  
pp. 45-50 ◽  
Author(s):  
Sungchul Kim ◽  
Eunhye Cha ◽  
Jongchul Lee ◽  
Seongjin Lee ◽  
Manyong Park ◽  
...  
Keyword(s):  
Toxicity Test ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

scholarly journals 26-Week Repeated Dose Oral Toxicity Study of KCHO-1 in Sprague-Dawley Rats

2019 ◽  
Vol 22 (3) ◽  
pp. 192-199
Author(s):  
Muhack Yang ◽  
Seongjin Lee ◽  
Tingting Wang ◽  
Eunhye Cha ◽  
Jongwon Jang ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

Four-week repeated dose oral toxicity study of KDS2010, a novel selective monoamine oxidase B inhibitor, in Sprague Dawley rats

2020 ◽  
Vol 117 ◽  
pp. 104733
Author(s):  
Kyung-Tai Kim ◽  
Da-Hee Kim ◽  
Bo-Kyung Kim ◽  
Ji-Seok Han ◽  
Han Young Eom ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Monoamine Oxidase B ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

Acute and repeated dose oral toxicity of N-acetyl-l-aspartic acid in Sprague–Dawley rats

2008 ◽  
Vol 46 (6) ◽  
pp. 2023-2034 ◽  
Author(s):  
Bryan Delaney ◽  
Z. Amanda Shen ◽  
Charles R. Powley ◽  
Shawn Gannon ◽  
Susan A. Munley ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral
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