Cross-Talk Between One-Carbon Metabolism and Xenobiotic Metabolism: Implications on Oxidative DNA Damage and Susceptibility to Breast Cancer

2011 ◽  
Vol 61 (3) ◽  
pp. 715-723 ◽  
Author(s):  
Shaik Mohammad Naushad ◽  
Cheruku Apoorva Reddy ◽  
Yedluri Rupasree ◽  
Addepalli Pavani ◽  
Raghunadha Rao Digumarti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cross Talk ◽  
Carbon Metabolism ◽  
Oxidative Dna Damage ◽  
Xenobiotic Metabolism ◽  
One Carbon Metabolism

Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer

2010 ◽  
Vol 349 (1-2) ◽  
pp. 159-167 ◽  
Author(s):  
Naushad Shaik Mohammad ◽  
Rupasree Yedluri ◽  
Pavani Addepalli ◽  
Suryanarayana Raju Gottumukkala ◽  
Raghunadha Rao Digumarti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Carbon Metabolism ◽  
Oxidative Dna Damage ◽  
Sporadic Breast Cancer ◽  
One Carbon Metabolism

Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer

2010 ◽  
Vol 38 (8) ◽  
pp. 4893-4901 ◽  
Author(s):  
Shaik Mohammad Naushad ◽  
Addepalli Pavani ◽  
Raghunadha Rao Digumarti ◽  
Suryanarayana Raju Gottumukkala ◽  
Vijay Kumar Kutala
Keyword(s):  
Breast Cancer ◽  
Carbon Metabolism ◽  
Epistatic Interactions ◽  
One Carbon Metabolism

scholarly journals B-Vitamin Intake, One-Carbon Metabolism, and Survival in a Population-Based Study of Women with Breast Cancer

2008 ◽  
Vol 17 (8) ◽  
pp. 2109-2116 ◽  
Author(s):  
Xinran Xu ◽  
Marilie D. Gammon ◽  
James G. Wetmur ◽  
Patrick T. Bradshaw ◽  
Susan L. Teitelbaum ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbon Metabolism ◽  
Population Based ◽  
Population Based Study ◽  
Vitamin Intake ◽  
One Carbon Metabolism ◽  
B Vitamin

scholarly journals Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation

Cell Reports ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2864-2873.e7 ◽  
Author(s):  
Mohamad-Ali Fawal ◽  
Thomas Jungas ◽  
Anthony Kischel ◽  
Christophe Audouard ◽  
Jason S. Iacovoni ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Neural Stem Cell ◽  
Cross Talk ◽  
Histone Methylation ◽  
Carbon Metabolism ◽  
Stem Cell Differentiation ◽  
One Carbon Metabolism

scholarly journals Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 225 ◽  
Author(s):  
Zhongliang Jiang ◽  
Yanhao Lai ◽  
Jill M. Beaver ◽  
Pawlos S. Tsegay ◽  
Ming-Lang Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Dna Damage ◽  
Dna Polymerase ◽  
Dna Methyltransferase ◽  
Oxidative Dna Damage ◽  
De Novo ◽  
Brca1 Gene ◽  
Methylation Pattern ◽  
Dna Polymerase Β

DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear. In this study, we seek to understand the mechanisms by exploring the effects of oxidative DNA damage on the DNA methylation pattern of the tumor suppressor breast cancer 1 (BRCA1) gene in the human embryonic kidney (HEK) HEK293H cells. We found that oxidative DNA damage simultaneously induced DNA demethylation and generation of new methylation sites at the CpGs located at the promoter and transcribed regions of the gene ranging from −189 to +27 in human cells. We demonstrated that DNA damage-induced demethylation was mediated by nucleotide misincorporation by DNA polymerase β (pol β). Surprisingly, we found that the generation of new DNA methylation sites was mediated by coordination between pol β and the de novo DNA methyltransferase, DNA methyltransferase 3b (DNMT3b), through the interaction between the two enzymes in the promoter and encoding regions of the BRCA1 gene. Our study provides the first evidence that oxidative DNA damage can cause dynamic changes in DNA methylation in the BRCA1 gene through the crosstalk between BER and de novo DNA methylation.

scholarly journals Cross-Talk between Carbon Metabolism and the DNA Damage Response in S. cerevisiae

Cell Reports ◽  
2015 ◽  
Vol 12 (11) ◽  
pp. 1865-1875 ◽  
Author(s):  
Kobi J. Simpson-Lavy ◽  
Alex Bronstein ◽  
Martin Kupiec ◽  
Mark Johnston
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Cross Talk ◽  
Carbon Metabolism ◽  
Damage Response

scholarly journals Correction: Huang, H.W.; et al. Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage. Molecules 2018, 23, 849

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1670
Author(s):  
Hurng-Wern Huang ◽  
Jen-Yang Tang ◽  
Fu Ou-Yang ◽  
Hui-Ru Wang ◽  
Pei-Ying Guan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Oxidative Dna Damage
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