Abstract 572: Induction of NAD(P)H-Quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer

2012 ◽  
Author(s):  
Hari K. Bhat ◽  
Bhupendra Singh
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Quinone Oxidoreductase

scholarly journals Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 225 ◽  
Author(s):  
Zhongliang Jiang ◽  
Yanhao Lai ◽  
Jill M. Beaver ◽  
Pawlos S. Tsegay ◽  
Ming-Lang Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Dna Damage ◽  
Dna Polymerase ◽  
Dna Methyltransferase ◽  
Oxidative Dna Damage ◽  
De Novo ◽  
Brca1 Gene ◽  
Methylation Pattern ◽  
Dna Polymerase Β

DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear. In this study, we seek to understand the mechanisms by exploring the effects of oxidative DNA damage on the DNA methylation pattern of the tumor suppressor breast cancer 1 (BRCA1) gene in the human embryonic kidney (HEK) HEK293H cells. We found that oxidative DNA damage simultaneously induced DNA demethylation and generation of new methylation sites at the CpGs located at the promoter and transcribed regions of the gene ranging from −189 to +27 in human cells. We demonstrated that DNA damage-induced demethylation was mediated by nucleotide misincorporation by DNA polymerase β (pol β). Surprisingly, we found that the generation of new DNA methylation sites was mediated by coordination between pol β and the de novo DNA methyltransferase, DNA methyltransferase 3b (DNMT3b), through the interaction between the two enzymes in the promoter and encoding regions of the BRCA1 gene. Our study provides the first evidence that oxidative DNA damage can cause dynamic changes in DNA methylation in the BRCA1 gene through the crosstalk between BER and de novo DNA methylation.

scholarly journals Correction: Huang, H.W.; et al. Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage. Molecules 2018, 23, 849

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1670
Author(s):  
Hurng-Wern Huang ◽  
Jen-Yang Tang ◽  
Fu Ou-Yang ◽  
Hui-Ru Wang ◽  
Pei-Ying Guan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Oxidative Dna Damage

Cross-Talk Between One-Carbon Metabolism and Xenobiotic Metabolism: Implications on Oxidative DNA Damage and Susceptibility to Breast Cancer

2011 ◽  
Vol 61 (3) ◽  
pp. 715-723 ◽  
Author(s):  
Shaik Mohammad Naushad ◽  
Cheruku Apoorva Reddy ◽  
Yedluri Rupasree ◽  
Addepalli Pavani ◽  
Raghunadha Rao Digumarti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cross Talk ◽  
Carbon Metabolism ◽  
Oxidative Dna Damage ◽  
Xenobiotic Metabolism ◽  
One Carbon Metabolism

scholarly journals Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Bhupendra Singh ◽  
Anwesha Chatterjee ◽  
Amruta M Ronghe ◽  
Nimee K Bhat ◽  
Hari K Bhat
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Oxidative Dna Damage
Sign in / Sign up

Export Citation Format

Share Document