Stem Cells: Implications in Experimental Ischaemic Stroke Therapy

2008 ◽  
Vol 4 (3) ◽  
pp. 227-233 ◽  
Author(s):  
Ashish K. Rehni ◽  
Inderbir Singh ◽  
Nirmal Singh ◽  
Manoj Kumar
Keyword(s):  
Stem Cells ◽  
Ischaemic Stroke ◽  
Stroke Therapy

Nanomedicine Directs Neuronal Differentiation of Neural Stem Cells via Silencing Long Noncoding RNA for Stroke Therapy

Nano Letters ◽  
2021 ◽  
Author(s):  
Bingling Lin ◽  
Liejing Lu ◽  
Yong Wang ◽  
Qinyuan Zhang ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Stroke Therapy

scholarly journals Prospects for the use of mesenchymal stem cells in stroke therapy

2019 ◽  
Vol 78 (1) ◽  
pp. 4-17
Author(s):  
T. T. Nurkenov ◽  
◽  
Sh. N. Askarova ◽  
A. K. Tsoy ◽  
Т. М. Shalakhmetova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stroke Therapy

scholarly journals Transplanted hair follicle stem cells migrate to the penumbra and express neural markers in a rat model of cerebral ischaemia/reperfusion

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Xuemei Zhang ◽  
Hao Tang ◽  
Senlin Mao ◽  
Bing Li ◽  
Yinglian Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischaemic Stroke ◽  
Hair Follicle ◽  
Cell Transplantation ◽  
Rat Model ◽  
Therapeutic Potential ◽  
Neural Regeneration ◽  
Ischaemia Reperfusion ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

Abstract Background Ischaemic stroke has become the main cause of death and severe neurological disorders, for which effective restorative treatments are currently limited. While stem cell transplantation offers therapeutic potential through neural regeneration, this approach is associated with the challenges of limited applicable sources. Hair follicle stem cells (HFSCs) are multipotential cells that can differentiate into ectodermal and mesodermal lineages and proliferate for long periods. The therapeutic potentials of HFSCs have not been investigated in ischaemic stroke models, and therefore, in this study, we aimed to determine whether they could survive and migrate to ischaemic areas after a stroke attack. Methods A rat model of middle cerebral artery ischaemia/reperfusion was established and intravenously administered HFSCs. The potential of HFSCs to migrate and differentiate into neuron-like cells as well as their ability to reduce the infarct size was evaluated. Rat brain tissue samples were collected 2 weeks after cell transplantation and analysed via TTC staining, immunofluorescence and immunohistochemistry methods. The data were statistically analysed and presented as the means ± standard deviations. Results Intravenously administrated rat HFSCs were able to migrate to the penumbra where they expressed neuron-specific markers, reduced the infarct volume and promoted neurological recovery. Conclusion HFSC transplantation has therapeutic potential for ischaemic stroke and is, therefore, worthy of further investigation toward possible clinical development for treating stroke patients.

scholarly journals The Battle of the Sexes for Stroke Therapy: Female- Versus Male-Derived Stem Cells

2013 ◽  
Vol 12 (3) ◽  
pp. 405-412 ◽  
Author(s):  
Yuji Kaneko ◽  
Mibel M. Pabon ◽  
Travis Dailey ◽  
Nathan L. Weinbren ◽  
Jessica Rizzi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stroke Therapy ◽  
Battle Of The Sexes

scholarly journals Transplanted Hair Follicle Stem Cells Migrate to the Penumbra and Express Neural Markers in a Rat Model of Cerebral Ischaemia/Reperfusion

2020 ◽  
Author(s):  
Xuemei Zhang ◽  
Hao Tang ◽  
Senlin Mao ◽  
Bing Li ◽  
Yinglian Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischaemic Stroke ◽  
Hair Follicle ◽  
Cell Transplantation ◽  
Rat Model ◽  
Therapeutic Potential ◽  
Neural Regeneration ◽  
Ischaemia Reperfusion ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

Abstract Background: Ischaemic stroke has become the main cause of death and severe neurological disorders, for which effective restorative treatments are currently limited. While stem cell transplantation offers therapeutic potential through neural regeneration, this approach is associated with challenges of limited applicable sources. Hair follicle stem cells (HFSCs) are multipotential cells which can differentiate into ectodermal and mesodermal lineages and proliferate for long periods. The therapeutic potentials of HFSCs have not been investigated in ischaemic stroke models and, therefore, in this study, we aimed to determine whether they can survive and migrate to ischaemic areas after stroke attack. Methods : A rat model of middle cerebral artery ischaemia/reperfusion was established and intravenously administrated HFSCs. The potential of HFSCs to migrate and differentiate into neuron-like cells, as well as their ability to reduce the infarct size, was evaluated. Rat brain tissue samples were collected 2 weeks after cell transplantation and analysed via TTC staining, immunofluorescence, and immunohistochemistry methods. The data were statistically analysed and are presented as the means ± standard deviations (SDs). Results : Intravenously administrated rat HFSCs migrated to the penumbra where they expressed neuron-specific markers, reduced the infarct volume, and promoted neurological recovery. Conclusion : HFSC transplantation has therapeutic potential for ischaemic stroke, which implies that HFSC treatment might be useful for stroke patients in the future and is, therefore, worthy of further investigation toward possible clinical development.

scholarly journals Using Dental Pulp Stem Cells for Stroke Therapy

2019 ◽  
Vol 10 ◽  
Author(s):  
Maria R. Gancheva ◽  
Karlea L. Kremer ◽  
Stan Gronthos ◽  
Simon A. Koblar
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Stroke Therapy

scholarly journals Corrigendum to ‘Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke’ [EBioMedicine 52 (2020) 102660]

EBioMedicine ◽  
2020 ◽  
Vol 55 ◽  
pp. 102751
Author(s):  
Guangtian Wang ◽  
Bing Han ◽  
Ling Shen ◽  
Shusheng Wu ◽  
Li Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Ischaemic Stroke ◽  
Functional Recovery ◽  
Circular Rna

scholarly journals Acute ischaemic stroke interventions: large vessel occlusion and beyond

2019 ◽  
Vol 5 (1) ◽  
pp. 80-85
Author(s):  
Ahmad Sweid ◽  
Batoul Hammoud ◽  
Sunidhi Ramesh ◽  
Daniella Wong ◽  
Tyler D Alexander ◽  
...  
Keyword(s):  
Ischaemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Mechanical Thrombectomy ◽  
Large Vessel ◽  
Large Vessel Occlusion ◽  
Stroke Therapy ◽  
Comprehensive Overview ◽  
Vessel Occlusion ◽  
Management Techniques ◽  
Randomised Controlled

Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy. Large vessel occlusion (LVO) accounts for up to 38% of acute ischaemic stroke and comes with devastating outcomes for patients, families and society in the pre-intervention era. A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke; this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits. This review article will present a comprehensive overview of LVO management, techniques and devices used, and the future of stroke therapy. In addition, we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion.

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