Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Combined with Cartilage Acellular Matrix Mediated Via Bone Morphogenic Protein 6 in a Rabbit Model of Articular Cruciate Ligament Transection

2020 ◽  
Vol 16 (3) ◽  
pp. 596-611 ◽  
Author(s):  
Hyo-Jin Jeon ◽  
Kyung-Ae Yoon ◽  
Eun Suk An ◽  
Tae-Wook Kang ◽  
Yun-Beom Sim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Cruciate Ligament ◽  
Rabbit Model ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Therapeutic Effects ◽  
Acellular Matrix

scholarly journals The regenerative effect of human umbilical cord blood mesenchymal stem cells in a rabbit model of osteoarthritis

2015 ◽  
Vol 42 (4) ◽  
pp. 163 ◽  
Author(s):  
Sherif El Bassiony ◽  
Ola Gharbia ◽  
AbdElmoaty Afify ◽  
HassanAbd El Ghaffar ◽  
AmiraK El Hawary ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Rabbit Model ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Regenerative Effect

SAT0546 The Regenerative Effect of Human Umbilical Cord Blood Mesenchymal Stem Cells in A Rabbit Model of Osteoarthritis

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 788.2-789
Author(s):  
A. A.-R. Youssef ◽  
A.E.A. Afifi ◽  
H.A. Abd El Ghaffar ◽  
S.R. El-Basuny ◽  
O.M. Gharbia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Rabbit Model ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Regenerative Effect

scholarly journals Cobalt Chloride Enhances the Anti-Inflammatory Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells through the ERK-HIF-1α-MicroRNA-146a-Mediated Signaling Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Jihye Kwak ◽  
Soo Jin Choi ◽  
Wonil Oh ◽  
Yoon Sun Yang ◽  
Hong Bae Jeon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Cobalt Chloride ◽  
Inflammatory Responses ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Therapeutic Effects ◽  
Anti Inflammatory

Human mesenchymal stem cells (hMSCs), including human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs), which have high proliferation capacity and immunomodulatory properties, are considered to be a good candidate for cell-based therapies. hMSCs show enhanced therapeutic effects via paracrine secretion or cell-to-cell contact that modulates inflammatory or immune reactions. Here, treatment with cobalt chloride (CoCl2) was more effective than naïve hUCB-MSCs in suppressing inflammatory responses in a coculture system with phytohemagglutinin- (PHA-) activated human peripheral blood mononuclear cells (hPBMCs). Furthermore, the effect of CoCl2 is exerted by promoting the expression of anti-inflammatory mediators (e.g., PGE2) and inhibiting that of inflammatory cytokines (e.g., TNF-α and IFN-γ). Treatment of hUCB-MSCs with CoCl2 leads to increased expression of microRNA- (miR-) 146a, which was reported to modulate anti-inflammatory responses. Hypoxia-inducible factor- (HIF-) 1α silencing and ERK inhibition abolished CoCl2-induced miR-146a expression, suggesting that ERK and HIF-1α signals are required for CoCl2-induced miR-146a expression in hUCB-MSCs. These data suggest that treatment with CoCl2 enhances the immunosuppressive capacity of hUCB-MSCs through the ERK-HIF-1α-miR-146a-mediated signaling pathway. Furthermore, pretreatment of transplanted MSCs with CoCl2 can suppress lung inflammation more than naïve MSCs can in a mouse model of asthma. These findings suggest that CoCl2 may improve the therapeutic effects of hUCB-MSCs for the treatment of inflammatory diseases.

Myogenic Potential of Mesenchymal Stem Cells - the Case of Adhesive Fraction of Human Umbilical Cord Blood Cells

2013 ◽  
Vol 8 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Iwona Grabowska ◽  
Wladyslawa Streminska ◽  
Katarzyna Janczyk-Ilach ◽  
Eugeniusz K. Machaj ◽  
Zygmunt Pojda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Myogenic Potential ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells
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