MSC-Derived Extracellular Vesicles in Preclinical Animal Models of Bone Injury: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Aidan M. Kirkham ◽  
Adrian J. M. Bailey ◽  
Alvin Tieu ◽  
Harinad B. Maganti ◽  
Joshua Montroy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Extracellular Vesicles ◽  
Meta Analysis ◽  
Bone Injury ◽  
Preclinical Animal Models

scholarly journals MSC-Derived Extracellular Vesicles in Preclinical Animal Models of Bone Injury: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 27 (3) ◽  
pp. S191
Author(s):  
Aidan Kirkham ◽  
Adrian Bailey ◽  
Alvin Tieu ◽  
Harinad Maganti ◽  
Joshua Montroy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Extracellular Vesicles ◽  
Meta Analysis ◽  
Bone Injury ◽  
Preclinical Animal Models

scholarly journals The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Wanying Xu ◽  
Dominique Pepper ◽  
Junfeng Sun ◽  
Judith Welsh ◽  
Xizhong Cui ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Clinical Studies ◽  
Animal Studies ◽  
Meta Analysis ◽  
Cecal Ligation ◽  
Severe Infection ◽  
Single Strain ◽  
Impact On Survival ◽  
Preclinical Animal Models

Background. Clinical studies suggest obesity paradoxically increases survival during bacterial infection and sepsis but decreases it with influenza, but these studies are observational. By contrast, animal studies of obesity in infection can prospectively compare obese versus nonobese controls. We performed a systematic review and meta-analysis of animal investigations to further examine obesity’s survival effect in infection and sepsis. Methods. Databases were searched for studies comparing survival in obese versus nonobese animals following bacteria, lipopolysaccharide, or influenza virus challenges. Results. Twenty-one studies (761 obese and 603 control animals) met the inclusion criteria. Obesity reduced survival in 19 studies (11 significantly) and the odds ratio (95% CI) of survival (0.21(0.13, 0.35); I2 = 64%, p<0.01p < 0.01) but with high heterogeneity. Obesity reduced survival (1) consistently in both single-strain bacteria- and lipopolysaccharide-challenged studies (n = 6 studies, 0.21(0.13, 0.34); I2 = 31%, p=0.20 and n = 5, 0.22(0.13, 0.36); I2 = 0%, p=0.59, respectively), (2) not significantly with cecal ligation and puncture (n = 4, 0.72(0.08, 6.23); I2 = 75%, p<0.01), and (3) significantly with influenza but with high heterogeneity (n = 6, 0.12(0.04, 0.34); I2 = 73%, p<0.01). Obesity’s survival effects did not differ significantly comparing the four challenge types (p=0.49). Animal models did not include antimicrobials or glycemic control and study quality was low. Conclusions. Preclinical and clinical studies together emphasize the need for prospective studies in patients accurately assessing obesity’s impact on survival during severe infection.

scholarly journals The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Naomi Dvir ◽  
Muhammad S. Javaid ◽  
Nigel C. Jones ◽  
Kim L. Powell ◽  
Patrick Kwan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Cell Transplantation ◽  
Meta Analysis ◽  
Treatment Options ◽  
Cell Therapies ◽  
Summary Estimate ◽  
Animal Models Of Epilepsy ◽  
Preclinical Animal Models ◽  
Models Of Epilepsy

Abstract Background Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It affects about 1% of the population worldwide. Despite a range of antiepileptic drugs being available, one third of the patients do not achieve adequate seizure control. Only a minority of these patients may be suitable to undergo surgical resection of the seizure focus, but this is an invasive and not always successful procedure. There is an urgent need to develop more effective treatment options for uncontrolled seizures. With the recent advances in regenerative and translational medicine, cell therapies could prove to be beneficial. Here we describe the protocol for a proposed systematic review and meta-analysis to assess the effects for cell transplantation in animal models of epilepsy. Methods We will include all preclinical animal models of epilepsy that evaluate the effects of cell transplantation compared to the untreated control. The primary outcome will be the change in frequency and duration of seizures from baseline measured by video electroencephalography (EEG). The secondary outcomes will include histological and neurobehavioural assessments. We will perform an electronic search of MEDLINE via PubMed, Web of Science, and EMBASE. Search results will be screened independently by two reviewers and confirmed by a third reviewer. Data from eligible studies will be extracted and pooled, and the summary estimate of effect size will be calculated using DerSimonian and Laird random effects meta-analysis. Heterogeneity will be explored using sub-group meta-analysis, and meta-regression risk of bias will be assessed by using the CAMARADES checklist for study quality tool. Discussion The purpose of this systematic review is to assess and summarise the existing literature in the field of cell transplantation as a treatment for epilepsy in animal models. Efficacy will be measured by evaluating the reduction in seizure intervals, number, and duration, within animal models of epilepsy. Analysis of the existing literature will mark the achievement made in the field and locate the existing gaps, a process that will aid in the search for the next needed step. Systematic review registration CRD42018103628

Oral administration of mangiferin ameliorates diabetes in animal models: a meta-analysis and systematic review

2020 ◽  
Author(s):  
You Wu ◽  
Wei Liu ◽  
Tao Yang ◽  
Mei Li ◽  
Lingling Qin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Oral Administration ◽  
Meta Analysis

Effects of sleep deprivation on maternal behaviour in animal models: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Gabriel N. Pires ◽  
Thainá B. Oliveira ◽  
Victoria F. F. Mello ◽  
Andréia G. Bezerra ◽  
Cathalijn H. C. Leenaars ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Sleep Deprivation ◽  
Meta Analysis ◽  
Maternal Behaviour

scholarly journals Efficacy of Deferoxamine in Animal Models of Intracerebral Hemorrhage: A Systematic Review and Stratified Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0127256 ◽  
Author(s):  
Han-Jin Cui ◽  
Hao-yu He ◽  
A-Li Yang ◽  
Hua-Jun Zhou ◽  
Cong Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Intracerebral Hemorrhage ◽  
Meta Analysis
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