Localization of the aromatase enzyme expression in the human pituitary gland and its effect on growth hormone, prolactin, and thyroid stimulating hormone axis

Endocrine ◽  
2015 ◽  
Vol 49 (3) ◽  
pp. 761-768 ◽  
Author(s):  
Asli Sezgin Caglar ◽  
Aysegul Kapucu ◽  
Kadriye Akgun Dar ◽  
Hande Mefkure Ozkaya ◽  
Erkan Caglar ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Thyroid Stimulating Hormone ◽  
Enzyme Expression ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Effect On Growth ◽  
Stimulating Hormone

THE LIPID-MOBILIZING EFFECT OF SOME PITUITARY GLAND PREPARATIONS

1967 ◽  
Vol 56 (4) ◽  
pp. 626-648 ◽  
Author(s):  
Olav Trygstad
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Serum Calcium Level ◽  
Human Growth ◽  
Pituitary Hormones ◽  
Unit Weight ◽  
Pituitary Hormone ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Gland Extract

ABSTRACT Lipid-mobilizing effect has been observed for nearly all the accepted pituitary hormones and for several suggested pituitary 'lipotrophins'. Pituitary hormone preparations are usually not homogeneous, and even a highly purified ACTH (p.ACTH) contains less than 30 per cent pure adrenocorticotrophin. Crude ACTH (c.ACTH) was found to be 250 times more adipokinetic in rabbits than p.ACTH, indicating that this effect was mainly due to impurities. A lipid-mobilizing fraction (LMFr) was precipitated from a human pituitary gland extract before the preparation of growth hormone and crude gonadotrophins, whereby the adipokinetic effect of these preparations in the rabbit became negligible. Removal of LMFr gave an electrophoretically purified growth hormone with reduced molecular weight and an increased somatotrophic potency per unit weight in a radioimmunoassay system. Injection of the lipotrophic preparations into rabbits lowered the serum calcium level, and concentrations below 3 meq./l were observed, often accompanied by convulsions and in some instances by death. It is concluded that the adipokinetic and hypocalcaemic effects of c.ACTH, p.ACTH and the employed human growth hormone preparations in rabbits may be due to contaminations. It is suggested that the LMFr contains a human pituitary lipotrophic factor which may also be responsible for the hypocalcaemia observed in the rabbit.

Somatostatin Octapeptides (Lanreotide, Octreotide, Vapreotide, and Their Analogs) Share the Growth Hormone–Releasing Peptide Receptor in the Human Pituitary Gland

Endocrine ◽  
2001 ◽  
Vol 14 (1) ◽  
pp. 029-033 ◽  
Author(s):  
Romano Deghenghi ◽  
Mauro Papotti ◽  
Ezio Ghigo ◽  
Giampiero Muccioli ◽  
Vittorio Locatelli
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Human Pituitary ◽  
Peptide Receptor ◽  
Human Pituitary Gland

scholarly journals Evidence for a nonprolactin, non-growth-hormone mammary mitogen in the human pituitary gland.

1987 ◽  
Vol 84 (22) ◽  
pp. 8110-8114 ◽  
Author(s):  
C. B. Newman ◽  
H. Cosby ◽  
H. G. Friesen ◽  
M. Feldman ◽  
P. Cooper ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland

EFFECTS OF TRI-IODOTHYRONINE, THYROXINE AND ISOPROPYL-DI-IODOTHYRONINE ON THYROID-STIMULATING HORMONE IN SERUM AND PITUITARY GLAND AND ON PITUITARY CONCENTRATIONS OF PROLACTIN, GROWTH HORMONE, LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE IN HYPOTHYROID RATS

1980 ◽  
Vol 87 (2) ◽  
pp. 255-263 ◽  
Author(s):  
C. C. WONG ◽  
K. -D. DÖHLER ◽  
A. VON ZUR MÜHLEN
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Pituitary Gland ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
Deficient Diet ◽  
Biological Potency ◽  
Suppression Test ◽  
Observation Period ◽  
Stimulating Hormone

Replacement of the 3′-halogen of the tri-iodothyronine (T3) molecule by a propyl-group produces a thyromimetic analogue, 3′-isopropyl-3,5-di-iodo-l-thyronine (T2iPr), with high biological potency. A serum thyroid-stimulating hormone (TSH) suppression test with one single intraperitoneal injection of 3 or 30 nm-T3 or T2iPr or with 30 or 300 nm-thyroxine (T4) per kg body weight was performed on 56 adult male Lewis rats which were maintained for 3 weeks on an iodine-deficient diet containing 0·2% 6n-propyl-2-thiouracil (PTU). Blood was withdrawn from each rat by cardiac puncture 24 h before and 3, 7, 24 and 48 h after application of the iodothyronines. Raised serum levels of TSH, due to the treatment with PTU, were significantly reduced within 3 h of treatment with 30 nm-T3, 300 nm-T4, 3 or 30 nm-T2iPr and they remained low throughout the observation period. Treatment with 3 nm-T3 or 30 nm-T4 per kg body weight was less effective. Pituitary concentrations of growth hormone, TSH, prolactin and FSH were significantly reduced by the treatment with PTU. There was also a slight, but insignificant reduction of pituitary concentrations of LH. Treatment with T3, T4 or T2iPr stimulated the reaccumulation of growth hormone, TSH, prolactin, LH and FSH in the pituitary gland.

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