Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland

2001 ◽  
Vol 24 (1) ◽  
pp. RC1-RC3 ◽  
Author(s):  
R. Deghenghi ◽  
M. Papotti ◽  
E. Ghigo ◽  
G. Muccioli
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Human Pituitary ◽  
Growth Hormone Secretagogue ◽  
Human Pituitary Gland

THE LIPID-MOBILIZING EFFECT OF SOME PITUITARY GLAND PREPARATIONS

1967 ◽  
Vol 56 (4) ◽  
pp. 626-648 ◽  
Author(s):  
Olav Trygstad
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Serum Calcium Level ◽  
Human Growth ◽  
Pituitary Hormones ◽  
Unit Weight ◽  
Pituitary Hormone ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Gland Extract

ABSTRACT Lipid-mobilizing effect has been observed for nearly all the accepted pituitary hormones and for several suggested pituitary 'lipotrophins'. Pituitary hormone preparations are usually not homogeneous, and even a highly purified ACTH (p.ACTH) contains less than 30 per cent pure adrenocorticotrophin. Crude ACTH (c.ACTH) was found to be 250 times more adipokinetic in rabbits than p.ACTH, indicating that this effect was mainly due to impurities. A lipid-mobilizing fraction (LMFr) was precipitated from a human pituitary gland extract before the preparation of growth hormone and crude gonadotrophins, whereby the adipokinetic effect of these preparations in the rabbit became negligible. Removal of LMFr gave an electrophoretically purified growth hormone with reduced molecular weight and an increased somatotrophic potency per unit weight in a radioimmunoassay system. Injection of the lipotrophic preparations into rabbits lowered the serum calcium level, and concentrations below 3 meq./l were observed, often accompanied by convulsions and in some instances by death. It is concluded that the adipokinetic and hypocalcaemic effects of c.ACTH, p.ACTH and the employed human growth hormone preparations in rabbits may be due to contaminations. It is suggested that the LMFr contains a human pituitary lipotrophic factor which may also be responsible for the hypocalcaemia observed in the rabbit.

Somatostatin Octapeptides (Lanreotide, Octreotide, Vapreotide, and Their Analogs) Share the Growth Hormone–Releasing Peptide Receptor in the Human Pituitary Gland

Endocrine ◽  
2001 ◽  
Vol 14 (1) ◽  
pp. 029-033 ◽  
Author(s):  
Romano Deghenghi ◽  
Mauro Papotti ◽  
Ezio Ghigo ◽  
Giampiero Muccioli ◽  
Vittorio Locatelli
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Human Pituitary ◽  
Peptide Receptor ◽  
Human Pituitary Gland

scholarly journals Evidence for a nonprolactin, non-growth-hormone mammary mitogen in the human pituitary gland.

1987 ◽  
Vol 84 (22) ◽  
pp. 8110-8114 ◽  
Author(s):  
C. B. Newman ◽  
H. Cosby ◽  
H. G. Friesen ◽  
M. Feldman ◽  
P. Cooper ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland

Localization of the aromatase enzyme expression in the human pituitary gland and its effect on growth hormone, prolactin, and thyroid stimulating hormone axis

Endocrine ◽  
2015 ◽  
Vol 49 (3) ◽  
pp. 761-768 ◽  
Author(s):  
Asli Sezgin Caglar ◽  
Aysegul Kapucu ◽  
Kadriye Akgun Dar ◽  
Hande Mefkure Ozkaya ◽  
Erkan Caglar ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Thyroid Stimulating Hormone ◽  
Enzyme Expression ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Effect On Growth ◽  
Stimulating Hormone

THE EXTRACTION OF PROLACTIN FROM HUMAN PITUITARY GLANDS

1965 ◽  
Vol 49 (1) ◽  
pp. 1-16 ◽  
Author(s):  
M. Apostolakis
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
List Type ◽  
Distilled Water ◽  
Hormone Activity ◽  
Isoelectric Precipitation ◽  
Human Pituitary ◽  
Pituitary Glands ◽  
Prolactin Content ◽  
The Mean

ABSTRACT A method for the extraction of prolactin from human pituitary glands is described. It is based on acetone drying, distilled water extraction, acetone and isoelectric precipitation. Two main products are obtained: Fraction R8 with a mean prolactin activity of 12.2 IU/mg and fraction U8 with a mean prolactin activity of 8.6 IU/mg. The former fraction does not contain any significant gonadotrophin activity and the latter contains on an average 50 HMG U/mg. In both cases contamination with ACTH and MSH is minimal. The growth hormone activity of both these fractions is low. It is postulated that in man too, prolactin and growth hormone are two distinct hormones. A total of 1250 human pituitary glands have been processed by this method. The mean prolactin content per pituitary gland has been found to be 73 IU.

The corticotrophic cells of the canine pituitary gland in pituitary-dependent hyperadrenocorticism

1983 ◽  
Vol 96 (2) ◽  
pp. 303-309 ◽  
Author(s):  
A. M. McNicol ◽  
H. Thomson ◽  
C. J. R. Stewart
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Single Entity ◽  
Pituitary Glands ◽  
Corticotrophic Cells

The distribution of specifically stained corticotrophic cells has been studied in the pituitary glands of 11 dogs with pituitary-dependent hyperadrenocorticism. The results suggest that the disease is not a single entity, and that some cases are caused by primary abnormality of the pituitary gland whereas others appear to be the result of dysfunction of the hypothalamus or central nervous system. The patterns correspond closely to those demonstrated in the human pituitary gland in Cushing's disease, and confirm that the canine disease is a useful model for the study of the pathogenesis of the variants of the condition.

Human Pituitary Growth Hormone, by Allen W. Root, M.D. Springfield, Illinois: Charles C Thomas, 1972, 259 pp. $10.50

PEDIATRICS ◽  
1973 ◽  
Vol 52 (1) ◽  
pp. 158-159
Author(s):  
Selna L. Kaplan
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Control Mechanisms ◽  
Human Pituitary ◽  
Comprehensive Review ◽  
Pituitary Growth Hormone ◽  
Biochemical Effects ◽  
Clinical Syndromes

This book, divided into four sections, provides a comprehensive review of the biochemical effects of growth hormone as well as the clinical syndromes associated with abnormalities of its secretion and metabolism. The book opens with a historical résumé of the "discovery" of this hormone, identification of its varied biologic actions, and isolation from the pituitary gland. The second part discusses the development of radioimmunoassay for measurement of growth hormone by Roth and associates and the subsequent surge in studies of the control mechanisms for the secretion of growth hormone.

Isolation of five active thyrotropin components from human pituitary gland

1975 ◽  
Vol 379 (1) ◽  
pp. 247-261 ◽  
Author(s):  
Paul Roos ◽  
D.V. Dervartanian ◽  
Gunilla Jacobson ◽  
Leif Wide
Keyword(s):  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland
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