Semaphorin-3A: a promising therapeutic tool in allergic rhinitis

2022 ◽  
Author(s):  
Ramin Lotfi ◽  
Nahid Zamanimehr
Keyword(s):  
Allergic Rhinitis ◽  
Semaphorin 3A ◽  
Therapeutic Tool

scholarly journals Subcutaneous Immunotherapy Improves the Symptomatology of Allergic Rhinitis

2015 ◽  
Vol 20 (01) ◽  
pp. 006-012 ◽  
Author(s):  
Edmir Lourenço ◽  
Eduardo Caldeira ◽  
César Carvalho ◽  
Marcelo Cunha ◽  
Marcus Carvalho ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Nasal Congestion ◽  
Average Score ◽  
Subcutaneous Immunotherapy ◽  
Therapeutic Tool ◽  
Pathological Conditions ◽  
In The Beginning ◽  
Subcutaneous Specific Immunotherapy

Introduction The relevance of allergic rhinitis is unquestionable. This condition affects people's quality of life and its incidence has increased over the last years. Objective Thus, this study aims to analyze the effectiveness of subcutaneous injectable immunotherapy in cases of nasal itching, sneeze, rhinorrhea and nasal congestion in allergic rhinitis patients. Methods In the present study, the same researcher analyzed the records of 281 patients. Furthermore, the researchers identified allergens through puncture cutaneous tests using standardized extracts containing acari, fungi, pet hair, flower pollen, and feathers. Then, the patients underwent treatment with subcutaneous specific immunotherapy, using four vaccine vials for desensitization, associated with environmental hygiene. The authors analyzed conditions of nasal itching, sneeze, rhinorrhea, and nasal congestion throughout the treatment, and assigned them with a score ranging from zero (0), meaning absence of these symptoms to three (3), for severe cases. The symptoms were statistically compared in the beginning, during, and after treatment. Results In this study, authors analyzed the cases distribution according to age and the evolution of symptomatology according to the scores, comparing all phases of treatment. The average score for the entire population studied was 2.08 before treatment and 0.44 at the end. These results represent an overall improvement of ∼79% in symptomatology of allergic rhinitis in the studied population. Conclusion The subcutaneous immunotherapy as treatment of allergic rhinitis led to a reduction in all symptoms studied, improving the quality of life of patients, proving itself as an important therapeutic tool for these pathological conditions.

scholarly journals SEMAPHORIN 3A - A NEW INTRATHYMIC SUPPRESSOR FACTOR

2019 ◽  
Vol 19 (1S) ◽  
pp. 203-205
Author(s):  
K V Rutto ◽  
E P Kisseleva
Keyword(s):  
Immune Responses ◽  
Axon Guidance ◽  
Cell Activity ◽  
Thymic Epithelial Cells ◽  
Neuronal System ◽  
Semaphorin 3A ◽  
Therapeutic Tool ◽  
Suppressor Factor ◽  
Immunosuppressive Factor

Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several semaphorins, so-called ‘immune semaphorins’, are also involved in various phases of immune responses. One of such factors is semaphorin 3A - a member of class 3 semaphorins, which are secretory molecules in vertebrates. There are multiple mechanisms involved in the process of semaphorin 3A-mediated regulation. One of them is down-regulation of peripheral T-cell activity in consequence of which semaphorin 3A is considered as an immunosuppressive factor. But semaphorin 3A is also expressed in the thymus while its function there remains obscure. Here are discussed new data on immunosuppressive function of this factor towards thymocytes and thymic epithelial cells, obtained in vitro. Because it is involved both in physiological immunoregulation and in the pathogenesis of many autoimmune, atopic, and malignant diseases, semaphorin 3A turns to be a promising therapeutic tool to be studied and applied in these diseases.

Semaphorin 3A inhibits allergic inflammation by regulating immune responses in a mouse model of allergic rhinitis

2018 ◽  
Vol 9 (5) ◽  
pp. 528-537 ◽  
Author(s):  
Rong Xiang ◽  
Yu Xu ◽  
Wei Zhang ◽  
Yong‐Gang Kong ◽  
Lu Tan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Immune Responses ◽  
Allergic Inflammation ◽  
Semaphorin 3A

Intranasal Administration of Semaphorin-3A Alleviates Sneezing and Nasal Rubbing in a Murine Model of Allergic Rhinitis

2011 ◽  
Vol 117 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Haruna Sawaki ◽  
Fumio Nakamura ◽  
Michiko Aihara ◽  
Yoji Nagashima ◽  
Junko Komori-Yamaguchi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Intranasal Administration ◽  
Semaphorin 3A

Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis

2005 ◽  
Vol 115 (3) ◽  
pp. 541-547 ◽  
Author(s):  
Andrea I. Koreck ◽  
Zsanett Csoma ◽  
Laszlo Bodai ◽  
Ferenc Ignacz ◽  
Anna Szabo Kenderessy ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Therapeutic Tool

Sequential degranulation of eosinophils induced by antigen or autocoids in allergic humans

1986 ◽  
Vol 44 ◽  
pp. 354-355
Author(s):  
Kate W. Sjoerdsma ◽  
W. James Metzger
Keyword(s):  
Allergic Rhinitis ◽  
Bronchoalveolar Lavage ◽  
Allergic Asthma ◽  
Skin Test ◽  
Positive Skin Test ◽  
Positive Skin ◽  
Human Eosinophil ◽  
Asthmatic Patients ◽  
Allergic Asthmatic ◽  
History Of

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.

Effects of Selected Rhinologic Disorders on the Perception of Nasal Resonance in Children

1984 ◽  
Vol 15 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Michael P. Rastatter ◽  
Melvin Hyman
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Implications ◽  
Normal Children ◽  
Nasal Resonance

A group of sophisticated listeners judged the nasal resonance characteristics of normal children versus children evidencing selected rhinologic disorders under three speaking conditions. Results showed that perceptions of denasality are influenced by both speakers and speaking tasks. That is, children with allergic rhinitis and edemic adenoids were perceived as being denasal when they produced VCV utterances and recited sentences. However, their resonance characteristics were deemed normal for vowel productions. Interestingly, children with severely deviated septums were judged to have normal nasal resonance under all speaking conditions. Clinical implications are discussed.

Phototherapy May Alleviate Allergic Rhinitis

2007 ◽  
Vol 38 (2) ◽  
pp. 22
Author(s):  
SHARON WORCESTER
Keyword(s):  
Allergic Rhinitis

Intranasal Corticosteroids, Inflammation, and Symptoms in Allergic Rhinitis

1999 ◽  
Vol 11 (1) ◽  
pp. 0004-0010 ◽  
Author(s):  
Niels Mygind ◽  
Lars Nielsen ◽  
Hans-Jürgen Hoffmann ◽  
Ronald Dahl ◽  
Henrik Jacobi
Keyword(s):  
Allergic Rhinitis ◽  
Intranasal Corticosteroids
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