Neural Stem Cells and New Neurons in the Cerebral Cortex of Stroke-Prone Spontaneously Hypertensive Rats After Stroke

2009 ◽  
Vol 41 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Tatsuki Itoh ◽  
Takao Satou ◽  
Kumiko Takemori ◽  
Shigeo Hashimoto ◽  
Hiroyuki Ito
Keyword(s):  
Stem Cells ◽  
Cerebral Cortex ◽  
Neural Stem Cells ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

SYSTEMIC DELIVERY OF ADULT STEM CELLS IMPROVES CARDIAC FUNCTION IN SPONTANEOUSLY HYPERTENSIVE RATS

2007 ◽  
Vol 0 (0) ◽  
pp. 071031221357009-??? ◽  
Author(s):  
Luisa MG de Macedo Braga ◽  
Kaleizu Rosa ◽  
Bruno Rodrigues ◽  
Christiane Malfitano ◽  
Melissa Camassola ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cardiac Function ◽  
Spontaneously Hypertensive Rats ◽  
Adult Stem Cells ◽  
Systemic Delivery ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

The Cerebral Cortex of Spontaneously Hypertensive Rats: A Quantitative Microanatomical Study

2004 ◽  
Vol 26 (4) ◽  
pp. 287-303 ◽  
Author(s):  
Fiorenzo Mignini ◽  
Lucia Vitaioli ◽  
Maurizio Sabbatini ◽  
Daniele Tomassoni ◽  
Francesco Amenta
Keyword(s):  
Cerebral Cortex ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Effects of Diabetic Hyperglycemia on Central Ang-(1-7)-Mas-R-nNOS Pathways in Spontaneously Hypertensive Rats

2016 ◽  
Vol 40 (5) ◽  
pp. 1186-1197 ◽  
Author(s):  
He Li ◽  
Xian Liu ◽  
Zhongqiao Ren ◽  
Jinxia Gu ◽  
Yingjie Lu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Cerebral Cortex ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Systemic Injection ◽  
Spontaneously Hypertensive ◽  
Arterial Blood ◽  
Cerebrovascular Dysfunction ◽  
And Control

Background/Aims: Hypertension is a major cause of stroke, and diabetes can increase incidence of this disease. We determined the role played by central angiotensin-(1-7) [Ang-(1-7)] pathway in modulating spontaneously hypertension with diabetic hyperglycemia. Methods: Western Blot analysis and ELISA were used to determine the protein expression of Ang-(1-7) and its signal pathway Mas-R-nNOS in the cerebral cortex and hippocampus of spontaneously hypertensive rats (SHR) and control animals. In a subset of animals, diabetic hyperglycemia was induced by systemic injection of streptozotocin (STZ). We analyzed a relationship between the levels of central Ang-(1-7) and plasma brain natriuretic peptide (BNP) indicating a risk of ischemic stroke. We further examined the effects of Ang-(1-7) on arterial blood pressure. Results: Our findings demonstrated for the first time that administration of STZ 1) attenuates the levels of Ang-(1-7) in the cerebral cortex and hippocampus, which are closely linked to plasma BNP; and 2) leads to downregulation of central Ang-(1-7)-Mas-R-nNOS pathways. Notably, STZ has greater effects in SHR. Additionally, inhibition of oxidative stress can largely improve downregulation of Ang-(1-7) in diabetic SHR. Moreover, central stimulation of Ang-(1-7) pathway or a blockade of oxidative stress improves systolic blood pressure in diabetic SHR. Conclusions: The Ang-(1-7) signaling pathway is engaged in the adaptive mechanisms associated with diabetic hypertension, suggesting that enhancing Ang-(1-7)-Mas-R-nNOS system is likely to be beneficial in preventing against cardiovascular and cerebrovascular dysfunction and vulnerability related to spontaneously hypertension, particularly to diabetic hypertension.

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