Family-Based Association Analysis of Serotonin Genes in Pathological Gambling Disorder: Evidence of Vulnerability Risk in the 5HT-2A Receptor Gene

2012 ◽  
Vol 49 (3) ◽  
pp. 550-553 ◽  
Author(s):  
David Wilson ◽  
Daniela Sabbatini da Silva Lobo ◽  
Hermano Tavares ◽  
Valentim Gentil ◽  
Homero Vallada
Keyword(s):  
Pathological Gambling ◽  
Association Analysis ◽  
Gambling Disorder ◽  
Receptor Gene ◽  
Family Based

DRD4 polymorphism predicts the effect of L-DOPA on gambling behaviour

2011 ◽  
Vol 26 (S2) ◽  
pp. 1049-1049
Author(s):  
C. Eisenegger ◽  
D. Knoch ◽  
R.P. Ebstein ◽  
L.R.R. Gianotti ◽  
P.S. Sándor ◽  
...  
Keyword(s):  
Pathological Gambling ◽  
Receptor Gene ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Gambling Behaviour ◽  
Addictive Disorders ◽  
D4 Receptor ◽  
Challenging Question ◽  
Dopaminergic Stimulation ◽  
Dopamine Modulation

A challenging question in the fields of neuroscience and addiction research is why some individuals are more vulnerable than others to addictive disorders. Pharmacogenetic studies investigating how genetic variation leads to differential drug response offer a way to unravel this mystery.In recent years, impulse control disorders, in particular pathological gambling, have been described in Parkinson's patients; these problems are most likely associated with dopaminergic treatment. Interestingly, only a subgroup of Parkinson's patients develops pathological gambling, raising the question whether there might be an interaction between genetic predisposition and dopaminergic drug administration. By applying a pharmacogenetic approach in 200 healthy subjects, we observed a differential effect of dopaminergic stimulation using 300 mg of L-DOPA on gambling behaviour, depending on variation in the dopamine D4 receptor gene. Carriers of the 7 repeats allele of the DRD4 exon III variable number tandem repeat polymorphism show an increased propensity to gamble after dopamine modulation. These findings may have implications for the dopaminergic treatment of Parkinson's disease patients by offering a genotype approach for determining individual susceptibilities for pathological gambling. They may also afford insights into the vulnerability mechanisms underlying addictive behaviour.

scholarly journals Family-based association analysis validates chromosome 3p21 as a putative nasopharyngeal carcinoma susceptibility locus

2006 ◽  
Vol 8 (3) ◽  
pp. 156-160 ◽  
Author(s):  
Zhaoyang Zeng ◽  
Yanhong Zhou ◽  
Wenling Zhang ◽  
Xiaoling Li ◽  
Wei Xiong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Association Analysis ◽  
Susceptibility Locus ◽  
Family Based ◽  
Chromosome 3P21

A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder

2007 ◽  
Vol 9 (2) ◽  
pp. 101-116
Author(s):  
Jonathan Savitz ◽  
Lize Merwe ◽  
Mark Solms ◽  
Rajkumar Ramesar
Keyword(s):  
Bipolar Disorder ◽  
Association Analysis ◽  
Family Based

scholarly journals Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus

2010 ◽  
Vol 19 (19) ◽  
pp. 3852-3862 ◽  
Author(s):  
B. Johanneson ◽  
S. K. McDonnell ◽  
D. M. Karyadi ◽  
P. Quignon ◽  
L. McIntosh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Association Analysis ◽  
Hereditary Prostate Cancer ◽  
Risk Locus ◽  
Family Based

Novel polymorphisms of the human cholecystokinin a receptor gene: An association analysis with schizophrenia

2000 ◽  
Vol 96 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Hirokazu Tachikawa ◽  
Shoji Harada ◽  
Yoichi Kawanishi ◽  
Takehito Okubo ◽  
Hiroyasu Shiraishi
Keyword(s):  
Association Analysis ◽  
Receptor Gene

Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children

2017 ◽  
Vol 30 (1) ◽  
pp. 203-211 ◽  
Author(s):  
Mark Wade ◽  
Heather Prime ◽  
Thomas J. Hoffmann ◽  
Louis A. Schmidt ◽  
Thomas G. O'Connor ◽  
...  
Keyword(s):  
Birth Weight ◽  
Executive Functioning ◽  
Receptor Gene ◽  
Interactive Effect ◽  
Oxytocin Receptor ◽  
Oxytocin Receptor Gene ◽  
Weight Variation ◽  
Major Allele ◽  
Family Based ◽  
And Function

AbstractGenetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children. The sample consisted of 310 children from an ongoing longitudinal study. EF was measured at age 4.5 using observational tasks indexing working memory, cognitive flexibility, and inhibitory control. A family-based design that controlled for population admixture, stratification, and nongenomic confounds was employed. A significant genetic association between rs2254298 and EF was observed, with more copies of the major allele (G) associated with higher EF. There was also a significant interaction between rs2254298 and birth weight, such that more copies of the major allele in combination with higher birth weight predicted better EF. Findings suggest that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development.

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