Upregulated Expression of NF-YC Contributes to Neuronal Apoptosis via Proapoptotic Protein Bim in Rats’ Brain Hippocampus Following Middle Cerebral Artery Occlusion (MCAO)

2013 ◽  
Vol 52 (4) ◽  
pp. 552-565 ◽  
Author(s):  
Yunfeng Wang ◽  
Chunhua Wan ◽  
Shanshan Yu ◽  
Lixiang Yang ◽  
Bing Li ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Neuronal Apoptosis ◽  
Artery Occlusion ◽  
Proapoptotic Protein ◽  
Cerebral Artery Occlusion

scholarly journals Apocynin promotes neural function recovery and suppresses neuronal apoptosis by inhibiting Tlr4/NF-κB signaling pathway in a rat model of cerebral infarction

2018 ◽  
Vol 32 ◽  
pp. 205873841881770
Author(s):  
Lemen Pan ◽  
Shuxia Qian
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Cerebral Infarction ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Neuronal Apoptosis ◽  
Artery Occlusion ◽  
Cerebral Artery Occlusion ◽  
And Oxidative Stress

Occlusion of arteries in the brain is a common cause of cerebral infarction which induces inflammatory response and oxidative stress resulting in neuronal apoptosis and disruption of neurological function. The present study investigated the protective roles of an nicotinamide adenine dinucleotide phosphate oxidase inhibitor, apocynin, against cerebral infarction. Rat went through a surgery of middle cerebral artery occlusion and a subset of rats was treated with apocynin by intraperitoneal injection. The volume of cerebral infarction and water content were measured. Neuronal apoptosis, inflammatory response, and oxidative stress were assessed following middle cerebral artery occlusion and apocynin treatment. We found that apocynin significantly improved neurological function, increased forelimb placement test scores, and suppressed balance beam walk latency in rats with cerebral infarction. Histological and biochemistry analysis revealed that apocynin lead to a significant reduction in the volume of cerebral infarction as well as cerebral water content, suppressed neuronal apoptosis, oxidative stress, and inflammatory response induced by middle cerebral artery occlusion. Finally, we found that apocynin suppressed Tlr4/nuclear factor-k-gene binding signaling pathway that was upregulated in rats with cerebral infarction. Our results indicate that apocynin may represent a potent therapeutic strategy in alleviating neurological dysfunctions in patients with cerebral infarction.

Expression of neurocan after transient middle cerebral artery occlusion in adult rat brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S217-S217
Author(s):  
Kentaro Deguchi ◽  
Mikiro Takaishi ◽  
Takeshi Hayashi ◽  
Atsuhiko Oohira ◽  
Shoko Nagotani ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Rat Brain ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Adult Rat ◽  
Adult Rat Brain ◽  
Cerebral Artery Occlusion

scholarly journals Dendritic Cells Are Present in Ischemic Brain After Permanent Middle Cerebral Artery Occlusion in the Rat

Stroke ◽  
2002 ◽  
Vol 33 (4) ◽  
pp. 1129-1134 ◽  
Author(s):  
Nikolaos Kostulas ◽  
Hu-Lun Li ◽  
Bao-Guo Xiao ◽  
Yu-Min Huang ◽  
Vasilios Kostulas ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Ischemic Brain ◽  
Cerebral Artery Occlusion
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