Effects of Regular Exercise on Diabetes-Induced Memory Deficits and Biochemical Parameters in Male Rats

2020 ◽  
Author(s):  
Seyed Asaad Karimi ◽  
Iraj Salehi ◽  
Mohammad Taheri ◽  
Nafiseh Faraji ◽  
Alireza Komaki
Keyword(s):  
Biochemical Parameters ◽  
Memory Deficits ◽  
Male Rats ◽  
Regular Exercise

scholarly journals Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats

IBRO Reports ◽  
2019 ◽  
Vol 7 ◽  
pp. 90-96 ◽  
Author(s):  
Amin Pirmoghani ◽  
Iraj Salehi ◽  
Shirin Moradkhani ◽  
Seyed Asaad Karimi ◽  
Sakineh Salehi
Keyword(s):  
Biochemical Parameters ◽  
Memory Deficits ◽  
Male Rats ◽  
Serum Biochemical Parameters ◽  
Serum Biochemical

Effects of paroxitine on biochemical parameters and reproductive function in male rats

2019 ◽  
Author(s):  
Rachid Mosbah ◽  
Aziz Chettoum ◽  
Zohir Djerrou ◽  
Alberto Mantovani
Keyword(s):  
Biochemical Parameters ◽  
Reproductive Function ◽  
Male Rats

scholarly journals Effects of peptidic growth hormone secretagogue receptor (GHS-R) antagonist [D-Lys3] on some of serum hormonal and biochemical parameters in Wistar rat model

2014 ◽  
Vol 58 (3) ◽  
pp. 288-291 ◽  
Author(s):  
Habib Aghdam Shahryar ◽  
Alireza Lotfi
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Serum Lipids ◽  
Considerable Increase ◽  
Wistar Rat ◽  
Male Rats ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Glucose Levels ◽  
Blood Glucose Levels

Objective : The present study investigated the effects of different dosages of a GHS-R antagonist [D-Lys3] on some serum hormonal (cortisol, T3 and T4) and biochemical parameters in a rat.Materials and methods : Thirty-six 60-day-old male rats were assigned to four treatments. [D-Lys3]-GHRP-6 solutions were infused via intraperitoneal injections. Blood was collected and analyzed.Results : The large dosages of a GHS-R antagonist (200 ng/kg BW) caused increases in cortisol, whereas no significant changes occurred when low dosages were injected. There were no significant changes in T3 and T4 following the administration of the GHS-R antagonist, but a considerable increase was observed in blood glucose levels of the groups (G50, G100, and G200 ng/kg BW). There was a significant increase in total protein when the greatest dose was administrated (G200 ng/kg BW). However, total cholesterol, triglycerides, and albumin showed no significant changes.Conclusions : Exogenous GHS-R antagonist can cause an increase in glucose and moderate increases in cortisol and total protein, yet it has no significant effect on T3 and T4 levels or on the concentrations of serum lipids. The effect of GHS-R antagonist is not completely adverse to the effects of ghrelin. Further molecular studies are necessary to identify the physiological effects of the peptidic GHS-R antagonist. Arq Bras Endocrinol Metab. 2014;58(3):288-91

scholarly journals The Effects of Oxymorphone on Biochemical Parameters of Male Rats

2018 ◽  
Author(s):  
Jamil Kheirvari Khezerloo ◽  
Tahereh Dianat ◽  
Mohsen Tabasi ◽  
Ali Salimi
Keyword(s):  
Biochemical Parameters ◽  
Male Rats

Maternal restraint stress during pregnancy negatively affects behaviors and antioxidant capacity of offspring rats (Rattus norvegicus)

2018 ◽  
Vol 96 (8) ◽  
pp. 882-887 ◽  
Author(s):  
Chao Yin ◽  
Guofu Wang ◽  
Shixing Gao ◽  
Yanping Huang ◽  
Ruqian Zhao ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Soleus Muscle ◽  
Rattus Norvegicus ◽  
Biochemical Parameters ◽  
Restraint Stress ◽  
Gastrocnemius Muscle ◽  
Female Offspring ◽  
Female Rats ◽  
Male Rats ◽  
Biochemical Indices

This study evaluated the effect of maternal restraint stress during the gestation period on behaviors, biochemical parameters, and antioxidant capacities of offspring rats (Rattus norvegicus (Berkenhout,1769)) at weaning age. Behaviors, plasma biochemical indices, and antioxidant ability of the liver, soleus muscle, and gastrocnemius muscle of mother and (or) offspring rats were analyzed. Significant increases were found in the immobility and swinging behavior frequencies of offspring male rats; no difference was found in behaviors of female rats. The antioxidant indices including superoxide dismutase, nitric oxide synthase, and total antioxidant capacity in the soleus muscle of offspring male rats were significantly decreased in the restraint group. Female offspring rats showed significant lower glutathione and higher malondialdehyde levels in the gastrocnemius muscle and liver, respectively. No difference was found in the productive performance and plasma biochemical indices of maternal rats, nor in the biochemical parameters of the two groups of weaning rats. The results suggested that maternal chronic stresses negatively affected the behaviors and antioxidant abilities of offspring rats, and that these effects possibly have a greater impact on offspring male rats than on female rats.

Habitual exercise attenuates myocardial stiffness in diabetes mellitus in rats

1996 ◽  
Vol 271 (5) ◽  
pp. H2126-H2133 ◽  
Author(s):  
A. J. Woodiwiss ◽  
W. J. Kalk ◽  
G. R. Norton
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Male Rats ◽  
Regular Exercise ◽  
Myocardial Wall ◽  
Hydroxyproline Concentration ◽  
Strain Relation ◽  
Wall Stiffness ◽  
Habitual Exercise ◽  
Advanced Glycosylation

The effects of regular voluntary (habitual) exercise on left ventricular (LV) diastolic performance, as well as on those hemodynamic, LV geometric and myocardial interstitial changes that influence myocardial diastolic function, were examined in streptozocin (50 mg/kg)-induced diabetes mellitus (DM) in male rats. After 16 wk of regular exercise on voluntary running wheels, cardiac performance was measured in anesthetized open-chest ventilated rats. Rats with DM developed a decrease in LV end diastolic (LVED) chamber and myocardial wall compliance associated with an increase in myocardial collagen fluorescence (a measure of collagen advanced glycosylation end product concentrations), an increase in systemic blood pressure, and a dilated LV. However, LV end-systolic elastance and total myocardial hydroxyproline concentration were unchanged. Habitual exercise prevented the augmented LVED chamber stiffness (slope of linearized LVED pressure-strain relation, DM vs. exercise DM, P < 0.01) and myocardial wall stiffness (slope of linearized LVED stress-strain relation, DM vs. exercise DM, P < 0.001) produced by DM. However, neither markers of blood glucose control, blood pressure, LV geometry, myocardial hydroxyproline concentration, nor collagen fluorescence were altered by the exercise program. A reduced LVED chamber and myocardial wall stiffness, as noted in euglycemic control rats in response to regular exercise, was also not associated with hemodynamic or myocardial interstitial alterations. Therefore, regular voluntary exercise opposes the decrement in myocardial diastolic performance produced by DM in male rats without influencing the accumulation of myocardial advanced glycosylation end products thought to be partly responsible for the stiff myocardium after chronic hyperglycemia. The beneficial effects of regular exercise on myocardial compliance are likely to be a consequence of changes in active as opposed to passive properties of the myocardial wall.

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