Comparative study of the immunohistochemical detection of hormone receptor status and HER-2 expression in primary and paired recurrent/metastatic lesions of patients with breast cancer

Background: Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Breast tumors in younger age groups were more likely to be of higher grade, hormone receptor– negative, poorly differentiated, and aneuploid, and to have high S-phase fraction, abnormal expression of P53, greater extent of lymphovascular invasion, and over-expression of human epidermal growth factor receptor 2 (HER-2) than breast tumors in older age groups. Methods: We organised a retrospective study of 600 women diagnosed with breast cancer, who have been operated from 2016 to 2020. We evaluated age, size, hormone receptor status, HER-2 receptor status. Estrogen receptor and progesterone receptor status were evaluated by immunohistochemistry. Results: Total 600 patient data was evaluated in this study. Rate of hormone positivity is more in older patients than in younger patients. Conclusions: In this study we conclude that the hormone positivity in younger patient is less as compared to older patients.

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Hormone Receptor Status in Breast Cancer and its Relation to Age and Other Prognostic Factors

Breast Cancer Basic and Clinical Research ◽

10.4137/bcbcr.s7199 ◽

2011 ◽

Vol 5 ◽

pp. BCBCR.S7199 ◽

Cited By ~ 2

Author(s):

Ali Pourzand ◽

M. Bassir A. Fakhree ◽

Shahryar Hashemzadeh ◽

Monireh Halimi ◽

Amir Daryani

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Progesterone Receptor ◽

Hormone Receptor ◽

Hormone Receptor Status ◽

Progesterone Receptor Status ◽

Cross Sectional ◽

P53 Expression ◽

Receptor Status ◽

Her 2

Background Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Patients and methods We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement. Results There is a direct correlation between positive progesterone receptor status and being younger than 40 ( P < 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages ( P < 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 overexpression ( P < 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant. Conclusions Although negative progesterone receptor tumors were more likely to have HER-2 overexpression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status.

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Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk

Obstetrics and Gynecology ◽

10.1097/01.aog.0000139789.22888.66 ◽

2004 ◽

Vol 104 (3) ◽

pp. 627

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Hormone Receptor ◽

Hormone Receptor Status ◽

Receptor Status

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Hormone receptor status in primary breast cancer—time for a consensus?

European Journal of Cancer ◽

10.1016/s0959-8049(01)00304-5 ◽

2002 ◽

Vol 38 (9) ◽

pp. 1201-1203 ◽

Cited By ~ 15

Author(s):

G.C Wishart ◽

M Gaston ◽

A.A Poultsidis ◽

A.D Purushotham

Keyword(s):

Breast Cancer ◽

Hormone Receptor ◽

Primary Breast Cancer ◽

Hormone Receptor Status ◽

Receptor Status

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A STUDY ON HORMONE RECEPTOR STATUS IN BREAST CANCER IN RELATION TO HISTOLOGICAL GRADING, AGE AND LYMPH NODE INVOLVEMENT

10.36106/ijar/1601400 ◽

2021 ◽

pp. 41-44

Author(s):

R. Rani Suganya ◽

M. Annapoorani ◽

C. Naveen Kumar

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Hormone Receptor ◽

Histological Grade ◽

Systemic Disease ◽

Lymph Node Involvement ◽

Hormone Receptor Status ◽

Major Health Problem ◽

Receptor Status ◽

Node Involvement

Breast cancer is the major health problem for the women throughout the world.Management of breast cancer has evolved to include both surgery for local disease and medical therapy for systemic disease. Multiple treatment options are available depending on various factors such as histological grade, hormone receptor status etc. The aim of this study is to correlate the hormone receptor status with prognostic factors such as lymph node involvement, tumour grading and age among patients diagnosed with breast cancer in our institution. The results of this study serve to prognosticate the severity of disease among various strata of patients.

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