Analytic study of hormone receptor status of breast cancer patients visiting in a tertiary care hospital of North-West India

Background: Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Breast tumors in younger age groups were more likely to be of higher grade, hormone receptor– negative, poorly differentiated, and aneuploid, and to have high S-phase fraction, abnormal expression of P53, greater extent of lymphovascular invasion, and over-expression of human epidermal growth factor receptor 2 (HER-2) than breast tumors in older age groups. Methods: We organised a retrospective study of 600 women diagnosed with breast cancer, who have been operated from 2016 to 2020. We evaluated age, size, hormone receptor status, HER-2 receptor status. Estrogen receptor and progesterone receptor status were evaluated by immunohistochemistry. Results: Total 600 patient data was evaluated in this study. Rate of hormone positivity is more in older patients than in younger patients. Conclusions: In this study we conclude that the hormone positivity in younger patient is less as compared to older patients.

Download Full-text

Hormone Receptor Status in Breast Cancer and its Relation to Age and Other Prognostic Factors

Breast Cancer Basic and Clinical Research ◽

10.4137/bcbcr.s7199 ◽

2011 ◽

Vol 5 ◽

pp. BCBCR.S7199 ◽

Cited By ~ 2

Author(s):

Ali Pourzand ◽

M. Bassir A. Fakhree ◽

Shahryar Hashemzadeh ◽

Monireh Halimi ◽

Amir Daryani

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Progesterone Receptor ◽

Hormone Receptor ◽

Hormone Receptor Status ◽

Progesterone Receptor Status ◽

Cross Sectional ◽

P53 Expression ◽

Receptor Status ◽

Her 2

Background Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Patients and methods We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement. Results There is a direct correlation between positive progesterone receptor status and being younger than 40 ( P < 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages ( P < 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 overexpression ( P < 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant. Conclusions Although negative progesterone receptor tumors were more likely to have HER-2 overexpression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status.

Download Full-text

Can the Reliance of Hormone Receptor Assays of Surgical Specimens Be Explained by the Fluctuation of Estrogen Receptor, Progesterone Receptor, and HER-2 Protein Expression in Tumor Samples of Premenopausal Breast Cancer Patients?

Journal of Clinical Oncology ◽

10.1200/jco.2005.03.9024 ◽

2005 ◽

Vol 23 (34) ◽

pp. 8918-8918 ◽

Cited By ~ 1

Author(s):

Andrea Alimonti ◽

Gianluigi Ferretti ◽

Francesco Cognetti

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Progesterone Receptor ◽

Protein Expression ◽

Cancer Patients ◽

Hormone Receptor ◽

Breast Cancer Patients ◽

Premenopausal Breast Cancer ◽

Her 2 ◽

Receptor Assays

Download Full-text

Comparative study of the immunohistochemical detection of hormone receptor status and HER-2 expression in primary and paired recurrent/metastatic lesions of patients with breast cancer

Medical Oncology ◽

10.1007/s12032-010-9418-2 ◽

2010 ◽

Vol 28 (1) ◽

pp. 57-63 ◽

Cited By ~ 45

Author(s):

Ebru Sari ◽

Gulnur Guler ◽

Mutlu Hayran ◽

Ibrahim Gullu ◽

Kadri Altundag ◽

...

Keyword(s):

Breast Cancer ◽

Comparative Study ◽

Hormone Receptor ◽

Hormone Receptor Status ◽

Immunohistochemical Detection ◽

Receptor Status ◽

Metastatic Lesions ◽

Her 2

Download Full-text

Hormone Receptor Status and TN Stage Influence the Locoregional Benefit From Trastuzumab in Patients With HER 2–Positive Breast Cancer After Adjuvant Radiation Therapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2014.05.864 ◽

2014 ◽

Vol 90 (1) ◽

pp. S244-S245

Author(s):

L. Cao ◽

G. Cai ◽

X. Yu ◽

J. Ma ◽

Z. Yang ◽

...

Keyword(s):

Breast Cancer ◽

Radiation Therapy ◽

Hormone Receptor ◽

Hormone Receptor Status ◽

Adjuvant Radiation ◽

Adjuvant Radiation Therapy ◽

Receptor Status ◽

Her 2 ◽

Positive Breast Cancer

Download Full-text

Estrogen receptor associated protein ERD 5 — relation to hormone receptor status in 347 breast cancer cytosols

Journal of Steroid Biochemistry ◽

10.1016/0022-4731(87)91612-8 ◽

1987 ◽

Vol 28 ◽

pp. 176

Author(s):

F. Jänicke ◽

W. Eiermann

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Hormone Receptor ◽

Hormone Receptor Status ◽

Receptor Status ◽

Receptor Associated Protein

Download Full-text

Incidence of triple receptor status (ER, PR, HER-2) in patients undergoing mastectomy in MMC and RGGGH, Chennai, India during 2010-2014: a prospective and retrospective study

International Surgery Journal ◽

10.18203/2349-2902.isj20182243 ◽

2018 ◽

Vol 5 (6) ◽

pp. 2305

Author(s):

P. Subramanian ◽

P. Venkateswaran

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Progesterone Receptor ◽

Postmenopausal Women ◽

General Hospital ◽

Age Groups ◽

Resected Specimen ◽

Age Group ◽

Carcinoma Breast ◽

Receptor Status

Background: Breast cancer is the most common of all cancers and is the leading cause of cancer deaths in women worldwide, accounting for about 1.5% of all deaths. A recent study in India revealed that 1 in 28 women develop breast cancer during their lifetime. Objective was to study the incidence of receptor status in patients who underwent mastectomy for carcinoma breast in Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, India.Methods: All women with carcinoma breast who had undergone a mastectomy in Rajiv Gandhi Government General Hospital in the past 5 years and their resected specimen tested for receptor status by pathologists. Estrogen receptor, Progesterone receptor, Her2/neu receptor by using special kits.Results: The most common type was found to be ER+ PR- Her2- and the least common was the Triple Positive type. Estrogen Receptor alone was positive in 63 patients. It was common for age groups 41-50 years and 31-40 years. Progesterone Receptor alone was positive in 17 patients. It was seen in age groups 51-60 years, 31-40 years, and 41-50 yrs. Her2 neu receptor alone was positive in 20 cases. It was most common in the age group 31-40 years (50% cases). Both ER and Her2/neu receptor were positive in 20 patients. The highest was among the age groups 41-50 years (35%) & 31-40 years (30%). All the three receptors were found to be positive in 8 cases with the highest being in the age group 41-50 years (4 cases) followed by 31-40 years (3 cases) and 51-60 years (1 case).Conclusions: The incidence of Progesterone receptor positivity was 32.5%. It was higher in postmenopausal women (36.25%) compared to premenopausal women (30%).The incidence of Her2/neu receptor positivity was found to be 32.5%. It was equally distributed in premenopausal and postmenopausal women (32.5%). The most common receptor subtype was ER+ve, PR-ve, Her2/neu-ve contributing 31.5%.

Download Full-text