scholarly journals Hormone Receptor Status in Breast Cancer and its Relation to Age and Other Prognostic Factors

2011 ◽  
Vol 5 ◽  
pp. BCBCR.S7199 ◽  
Author(s):  
Ali Pourzand ◽  
M. Bassir A. Fakhree ◽  
Shahryar Hashemzadeh ◽  
Monireh Halimi ◽  
Amir Daryani
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Progesterone Receptor ◽  
Hormone Receptor ◽  
Hormone Receptor Status ◽  
Progesterone Receptor Status ◽  
Cross Sectional ◽  
P53 Expression ◽  
Receptor Status ◽  
Her 2

Background Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Patients and methods We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement. Results There is a direct correlation between positive progesterone receptor status and being younger than 40 ( P < 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages ( P < 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 overexpression ( P < 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant. Conclusions Although negative progesterone receptor tumors were more likely to have HER-2 overexpression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status.

scholarly journals Analytic study of hormone receptor status of breast cancer patients visiting in a tertiary care hospital of North-West India

2021 ◽  
Vol 8 (2) ◽  
pp. 612
Author(s):  
Vikas Kakkar ◽  
Arvind Kaushal ◽  
Swaraj Hanspal ◽  
Karanvir Singh ◽  
Anmol Randhawa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Hormone Receptor ◽  
Older Patients ◽  
Age Groups ◽  
Breast Tumors ◽  
Hormone Receptor Status ◽  
Receptor Status ◽  
Her 2

Background: Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Breast tumors in younger age groups were more likely to be of higher grade, hormone receptor– negative, poorly differentiated, and aneuploid, and to have high S-phase fraction, abnormal expression of P53, greater extent of lymphovascular invasion, and over-expression of human epidermal growth factor receptor 2 (HER-2) than breast tumors in older age groups.  Methods: We organised a retrospective study of 600 women diagnosed with breast cancer, who have been operated from 2016 to 2020. We evaluated age, size, hormone receptor status, HER-2 receptor status. Estrogen receptor and progesterone receptor status were evaluated by immunohistochemistry. Results: Total 600 patient data was evaluated in this study. Rate of hormone positivity is more in older patients than in younger patients.  Conclusions: In this study we conclude that the hormone positivity in younger patient is less as compared to older patients.  

A STUDY ON HORMONE RECEPTOR STATUS IN BREAST CANCER IN RELATION TO HISTOLOGICAL GRADING, AGE AND LYMPH NODE INVOLVEMENT

2021 ◽  
pp. 41-44
Author(s):  
R. Rani Suganya ◽  
M. Annapoorani ◽  
C. Naveen Kumar
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Hormone Receptor ◽  
Histological Grade ◽  
Systemic Disease ◽  
Lymph Node Involvement ◽  
Hormone Receptor Status ◽  
Major Health Problem ◽  
Receptor Status ◽  
Node Involvement

Breast cancer is the major health problem for the women throughout the world.Management of breast cancer has evolved to include both surgery for local disease and medical therapy for systemic disease. Multiple treatment options are available depending on various factors such as histological grade, hormone receptor status etc. The aim of this study is to correlate the hormone receptor status with prognostic factors such as lymph node involvement, tumour grading and age among patients diagnosed with breast cancer in our institution. The results of this study serve to prognosticate the severity of disease among various strata of patients.

scholarly journals Evaluation of the association between HIF-1α and HER-2 expression, hormone receptor status, Ki-67 expression, histology and tumor FDG uptake in breast cancer

2016 ◽  
Vol 12 (5) ◽  
pp. 3889-3895 ◽  
Author(s):  
Sevi̇m Sureyya Cerci ◽  
Kemal Kursat Bozkurt ◽  
Hasan Erol Eroglu ◽  
Celal Cerci ◽  
Evrim Erdemoglu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Hormone Receptor Status ◽  
Ki 67 ◽  
Receptor Status ◽  
Fdg Uptake ◽  
Her 2

scholarly journals Comparison of Grading and ER, PR Hormone Receptor Status of Carcinoma Breast in FNAC with Histopathology - A Cross Sectional Study from Thrissur, Kerala

2021 ◽  
Vol 8 (21) ◽  
pp. 1696-1700
Author(s):  
Suma Madathiveetil ◽  
Jisha Kalathil Thodiyil ◽  
Freena Rose
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Cross Sectional Study ◽  
Hormone Receptor Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Carcinoma Breast ◽  
Receptor Status ◽  
Common Cancer ◽  
Number Of Patients

BACKGROUND Breast cancer is now the most common cancer in cities in India and 2 nd most common cancer in the rural areas. Fine needle aspiration cytology (FNAC) is a less invasive pre-operative diagnostic method and is preferred over core / excision biopsy to decide the benign or malignant nature of the breast lump. Prognostic factor assessment by FNAC would allow the identification of patients who would benefit from neo adjuvant treatment (patients with grade 3 tumours) and in whom conservation surgery is inadvisable.1 The purpose of this study is to compare the grades of breast cancer in FNAC with histopathology as gold standard and compare the oestrogen (ER) and progesterone (PR) hormonal expression pattern on immunocytochemistry (ICC) with immunohistochemistry (IHC). From this study we intend to assess the usefulness of cytological grading and ER, PR hormone receptor status pre-operatively so that hormonal therapy can be included with neoadjuvant chemotherapy. METHODS This is a cross sectional study with a sample size of 50, conducted in the Department of Pathology. RESULTS Out of 50 cases, maximum number of patients were in the age group of 51 - 60 years. 68 % had attained menopause; 69 % of patients had tumour size between 2 - 5 cm and 90 % of tumours were in the upper outer quadrant of breast. Considering hormonal expression, in case of ER there was a moderate agreement between ICC and IHC (κ = .428, P = 0.005) and no agreement was seen in case of PR (κ = .073, P = 0.625). Regarding the cytological grading, this study showed highest degree of concordance with grade II tumours with a sensitivity of 75.9 %. For Grade I it was 2.5 % and for grade III, it was 33.3 %. CONCLUSIONS Evaluation of hormonal status and nuclear grading is fairly reliable on cytology when performed on qualitatively superior FNAC material from the primary breast lesions. KEYWORDS Carcinoma Breast, FNAC, ER / PR, Immunocytochemistry, Immunohistochemistry, Cytological Nuclear Grading

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