Aberrant gene promoter methylation of E-cadherin, p16 INK4a , p14 ARF , and MGMT in Epstein–Barr virus-associated oral squamous cell carcinomas

2017 ◽  
Vol 34 (7) ◽  
Author(s):  
Ati Burassakarn ◽  
Chamsai Pientong ◽  
Nuchsupha Sunthamala ◽  
Jureeporn Chuerduangphui ◽  
Patravoot Vatanasapt ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Promoter Methylation ◽  
Epstein Barr Virus ◽  
Gene Promoter ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Barr Virus ◽  
P16 Ink4a ◽  
Epstein Barr ◽  
Aberrant Gene

Epstein-Barr virus infection is strictly associated with the metastatic spread of sinonasal squamous-cell carcinomas

Oral Oncology ◽  
2015 ◽  
Vol 51 (10) ◽  
pp. 929-934 ◽  
Author(s):  
Johannes Doescher ◽  
Guido Piontek ◽  
Markus Wirth ◽  
Marcus Bettstetter ◽  
Juergen Schlegel ◽  
...  
Keyword(s):  
Virus Infection ◽  
Squamous Cell ◽  
Epstein Barr Virus ◽  
Squamous Cell Carcinomas ◽  
Metastatic Spread ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Epstein-Barr virus and carcinomas: Undifferentiated carcinomas but not squamous cell carcinomas of the nasopharynx are regularly associated with the virus

1991 ◽  
Vol 165 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Gerald Niedobitek ◽  
Martin L. Hansmann ◽  
Hermann Herbst ◽  
Lawrence S. Young ◽  
Dieter Dienemann ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Epstein Barr Virus ◽  
Squamous Cell Carcinomas ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals p73 gene promoter methylation in Epstein-Barr virus-associated gastric carcinoma

2006 ◽  
Vol 120 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Tetsuo Ushiku ◽  
Ja-Mun Chong ◽  
Hiroshi Uozaki ◽  
Rumi Hino ◽  
Moon-Sung Chang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Promoter Methylation ◽  
Epstein Barr Virus ◽  
Gene Promoter ◽  
Barr Virus ◽  
P73 Gene ◽  
Epstein Barr

Detection of Epstein-Barr virus Genome in Squamous Cell Carcinomas of the Larynx

1995 ◽  
Vol 10 (4) ◽  
pp. 211-215 ◽  
Author(s):  
H. Kiaris ◽  
M. Ergazaki ◽  
J. Segas ◽  
D.A. Spandidos
Keyword(s):  
Squamous Cell ◽  
Normal Tissue ◽  
Epstein Barr Virus ◽  
Tumor Tissue ◽  
Virus Genome ◽  
Squamous Cell Carcinomas ◽  
Adjacent Normal Tissue ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr

Epstein-Barr virus (EBV) is a B-lymphotropic virus with a tumorigenic potential. EBV infection has been recognized as the main cause of nasopharyngeal carcinoma and Burkitt's lymphoma. The aim of our study was to determine the incidence of EBV in squamous cell carcinomas of the larynx. We employed for our analysis a sensitive polymerase chain reaction (PCR) assay, followed by restriction fragment length polymorphism (RFLP) for further confirmation of the specificity of the PCR-amplification reaction. Our analysis revealed that 9 of 27 (33%) specimens harbored the EBV genome in the tumor tissue while only 4 (15%) specimens from adjacent normal tissue exhibited evidence of EBV infection. Three were EBV positive for both normal and tumor tissue. No association has been found with disease stage, histological differentiation and nodes at pathology. The relatively high incidence of EBV in the tumor tissue (33%) of patients with laryngeal cancer, as compared to the low (15%) incidence of the virus genome detected in the adjacent normal tissue of the patients, indicates a probable role of EBV in the development of the disease.

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