Regulation of Autophagy and Ubiquitinated Protein Accumulation by bFGF Promotes Functional Recovery and Neural Protection in a Rat Model of Spinal Cord Injury

2013 ◽  
Vol 48 (3) ◽  
pp. 452-464 ◽  
Author(s):  
Hong-Yu Zhang ◽  
Zhou-Guang Wang ◽  
Fen-Zan Wu ◽  
Xiao-Xia Kong ◽  
Jie Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Rat Model ◽  
Protein Accumulation ◽  
Ubiquitinated Protein ◽  
Cord Injury

scholarly journals Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury

2020 ◽  
Vol 34 (5) ◽  
pp. 6984-6998
Author(s):  
Ningning Chen ◽  
Pengxiang Zhou ◽  
Xizhe Liu ◽  
Jiachun Li ◽  
Yong Wan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Rat Model ◽  
Injured Spinal Cord ◽  
Cord Injury

scholarly journals Galantamine improves functional recovery and reduces lesion size in a rat model of spinal cord injury

2019 ◽  
Vol 1724 ◽  
pp. 146424 ◽  
Author(s):  
Laura E. Sperling ◽  
Karina Pires Reis ◽  
Fabricio Nicola ◽  
Cristian Euzebio Teixeira ◽  
Gabriele Gulielmin Didó ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Rat Model ◽  
Lesion Size ◽  
Cord Injury

scholarly journals Functional Recovery after the Transplantation of Neurally Differentiated Mesenchymal Stem Cells Derived from Bone Barrow in a Rat Model of Spinal Cord Injury

2009 ◽  
Vol 18 (12) ◽  
pp. 1359-1368 ◽  
Author(s):  
Sung-Rae Cho ◽  
Yong Rae Kim ◽  
Hoi-Sung Kang ◽  
Sun Hee Yim ◽  
Chang-il Park ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Functional Recovery ◽  
Rat Model ◽  
Cord Injury

Functional recovery after transplantation of bone marrow-derived human mesenchymal stromal cells in a rat model of spinal cord injury

Cytotherapy ◽  
2010 ◽  
Vol 12 (6) ◽  
pp. 792-806 ◽  
Author(s):  
Rakhi Pal ◽  
Chaitanya Gopinath ◽  
Nagesh M Rao ◽  
Poulomi Banerjee ◽  
Venkatesh Krishnamoorthy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Mesenchymal Stromal Cells ◽  
Functional Recovery ◽  
Rat Model ◽  
Stromal Cells ◽  
Human Mesenchymal Stromal Cells ◽  
Cord Injury

Functional Recovery of Carbon Nanotube/Nafion Nanocomposite in Rat Model of Spinal Cord Injury

2015 ◽  
Vol 44 (1) ◽  
pp. 144-149 ◽  
Author(s):  
Saber Imani ◽  
Zahra Zagari ◽  
Saeid Rezaei Zarchi ◽  
Masomeh Jorjani ◽  
Sima Nasri
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Carbon Nanotube ◽  
Functional Recovery ◽  
Rat Model ◽  
Cord Injury

scholarly journals Ultrasound stimulation improves inflammatory resolution, neuroprotection, and functional recovery after spinal cord injury

2021 ◽  
Author(s):  
Yu-ri Hong ◽  
Eun-hee Lee ◽  
Ki-su Park ◽  
Mun Han ◽  
Kyoung-Tae Kim ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Inflammatory Response ◽  
Motor Function ◽  
Functional Recovery ◽  
Rat Model ◽  
Inflammatory Responses ◽  
Injury Site ◽  
Cord Injury ◽  
Anti Inflammatory

Abstract Spinal cord injury (SCI) is associated with limited functional recovery. Despite advances in neuroscience, realistic therapeutic treatments for SCI remain unavailable. In this study, the effects of non-invasive ultrasound (US) treatment on behavior and inflammatory responses were evaluated in a rat model of SCI. Adult female Sprague–Dawley rats were subjected to spinal cord contusion injury. Two different US parameters (SCIU5: 5% and SCIU40: 40% duty cycle) were applied, and their effects on behavioral recovery after SCI were quantified. Tissue and neuronal responses were detected. Immunofluorescence was used to detect inflammatory markers. In the rat model of SCI, motor function was more effectively restored, and the lesion cavity area was smaller in the SCIU5 group. Furthermore, the SCIU5 protocol elicited an anti-inflammatory response at the injury site by reducing degenerative FJC-labeled neurons, macrophage/microglia activation, and infiltration. Thus, the lesion area decreased, and tissue density increased. Meanwhile, the SCIU40 protocol did not improve motor function or induce an anti-inflammatory response at the injury site. The SCIU5 protocol effectively accelerated the rate of improved exercise performance in the rat model while reducing inflammation. Accordingly, appropriate US stimulation may represent a promising treatment modality for SCI with beneficial anti-inflammatory effects.

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