scholarly journals Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate

2014 ◽  
Vol 50 (1) ◽  
pp. 26-37 ◽  
Author(s):  
Kinga Czubowicz ◽  
Robert Strosznajder
Keyword(s):  
Cell Death ◽  
Molecular Mechanisms ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Sphingosine 1 Phosphate

scholarly journals Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease

2019 ◽  
Vol 20 (13) ◽  
pp. 3131 ◽  
Author(s):  
Nami Kim ◽  
Dongmei Chen ◽  
Xiao Zhen Zhou ◽  
Tae Ho Lee
Keyword(s):  
Cell Death ◽  
Protein Kinase ◽  
Neurodegenerative Diseases ◽  
Molecular Mechanisms ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Biological Processes ◽  
Death Associated Protein Kinase ◽  
The Brain

Regulated neuronal cell death plays an essential role in biological processes in normal physiology, including the development of the nervous system. However, the deregulation of neuronal apoptosis by various factors leads to neurodegenerative diseases such as ischemic stroke and Alzheimer’s disease (AD). Death-associated protein kinase 1 (DAPK1) is a calcium/calmodulin (Ca2+/CaM)-dependent serine/threonine (Ser/Thr) protein kinase that activates death signaling and regulates apoptotic neuronal cell death. Although DAPK1 is tightly regulated under physiological conditions, DAPK1 deregulation in the brain contributes to the development of neurological disorders. In this review, we describe the molecular mechanisms of DAPK1 regulation in neurons under various stresses. We also discuss the role of DAPK1 signaling in the phosphorylation-dependent and phosphorylation-independent regulation of its downstream targets in neuronal cell death. Moreover, we focus on the major impact of DAPK1 deregulation on the progression of neurodegenerative diseases and the development of drugs targeting DAPK1 for the treatment of diseases. Therefore, this review summarizes the DAPK1 phosphorylation signaling pathways in various neurodegenerative diseases.

Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death

1999 ◽  
Vol 46 (5) ◽  
pp. 787-790 ◽  
Author(s):  
Gillian M. Borthwick ◽  
Margaret A. Johnson ◽  
Paul G. Ince ◽  
Pamela J. Shaw ◽  
Douglass M. Turnbull
Keyword(s):  
Cell Death ◽  
Amyotrophic Lateral Sclerosis ◽  
Enzyme Activity ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mitochondrial Enzyme ◽  
Lateral Sclerosis

scholarly journals Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway

2021 ◽  
Author(s):  
Eun Ji Yeo ◽  
Won Sik Eum ◽  
Hyeon Ji Yeo ◽  
Yeon Joo Choi ◽  
Eun Jeong Sohn ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Protective Role ◽  
Signal Pathway ◽  
Mapk Signal Pathway

The role of nitric oxide and PARP in neuronal cell death

2005 ◽  
pp. 146-156
Author(s):  
Mika Shimoji ◽  
Valina L. Dawson ◽  
Ted M. Dawson
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell

scholarly journals Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death

Brain ◽  
2008 ◽  
Vol 131 (11) ◽  
pp. 3019-3033 ◽  
Author(s):  
Ik-Hyun Cho ◽  
Jinpyo Hong ◽  
Eun Cheng Suh ◽  
Jae Hwan Kim ◽  
Hyunkyoung Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Kainic Acid ◽  
Neuronal Cell Death ◽  
Neuronal Cell

Role of caspase-3 in neuronal cell death

1998 ◽  
Vol 5 ◽  
pp. 207
Author(s):  
A. Gorman ◽  
E. Bonfoco ◽  
B. Zhivotovsky ◽  
S. Orrenius ◽  
S. Ceccatelli
Keyword(s):  
Cell Death ◽  
Caspase 3 ◽  
Neuronal Cell Death ◽  
Neuronal Cell

scholarly journals Role of Cathepsin D in U18666A-induced Neuronal Cell Death

2012 ◽  
Vol 288 (5) ◽  
pp. 3136-3152 ◽  
Author(s):  
Asha Amritraj ◽  
Yanlin Wang ◽  
Timothy J. Revett ◽  
David Vergote ◽  
David Westaway ◽  
...  
Keyword(s):  
Cell Death ◽  
Cathepsin D ◽  
Neuronal Cell Death ◽  
Neuronal Cell
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