scholarly journals Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial

2009 ◽  
Vol 3 (3) ◽  
pp. 445-452 ◽  
Author(s):  
Michiko Shindo ◽  
Kazuaki Chayama ◽  
Satoshi Mochida ◽  
Joji Toyota ◽  
Eiichi Tomita ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Chronic Hepatitis B ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Japanese Adult ◽  
Double Blind

Nasal decongestant effect of oxymetazoline in the common cold: An objective dose-response study in 106 patients

1989 ◽  
Vol 103 (8) ◽  
pp. 743-746 ◽  
Author(s):  
Anders Åkerland ◽  
Thorsten Klint ◽  
Lars Olén ◽  
Hans Rundcrantz
Keyword(s):  
Clinical Trial ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Double Blind ◽  
Nasal Decongestant ◽  
Double Blind Clinical Trial ◽  
Symptom Scores ◽  
The Common ◽  
Dose Response Study

AbstractOxymetazoline has been used as decongesting nosedrops for more than 25 years but so far no objective does-response study of the drug has been published. In this double-blind clinical trial the decongestant effect on the nasal mucosa by the doses and concentrations traditionally used of oxymetazoline were studied.In 106 men with acute infectious rhinitis, a significant dose-response relationship was found when the decongestant effect was measured objectively by anterior rhinomanometry and subjectively by symptom scores.The concentration and volumes of the drug recommended from clinical experience seem to be adequate.

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