scholarly journals The role of CCN family genes in haematological malignancies

2015 ◽  
Vol 9 (3) ◽  
pp. 267-278 ◽  
Author(s):  
J. E. Wells ◽  
M. Howlett ◽  
L. C. Cheung ◽  
Ursula R. Kees
Keyword(s):  
Haematological Malignancies ◽  
Ccn Family

Perianal sepsis in neutropaenic patients with haematological malignancies: the role of magnetic resonance imaging and surgery

2020 ◽  
Vol 90 (9) ◽  
pp. 1642-1646
Author(s):  
Claudia Ashkar ◽  
Maneka Britto ◽  
Peter Carne ◽  
Wa Cheung ◽  
Naseem Mirbagheri
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Haematological Malignancies ◽  
Resonance Imaging ◽  
Perianal Sepsis

scholarly journals A clearer light on the role of NK cells in haematological malignancies

2017 ◽  
Vol 179 (3) ◽  
pp. 359-360
Author(s):  
Peter Hokland ◽  
Marianne Hokland
Keyword(s):  
Nk Cells ◽  
Haematological Malignancies

The role of cytology in the diagnosis of haematological malignancies

Cytopathology ◽  
2019 ◽  
Vol 30 (4) ◽  
pp. 345-347
Author(s):  
Maria Calaminici ◽  
Sabine Pomplun
Keyword(s):  
Haematological Malignancies

The Role of Bronchoalveolar Lavage in the Microbiological Diagnosis of Pneumonia in Patients with Haematological Malignancies

1997 ◽  
Vol 29 (6) ◽  
pp. 535-540 ◽  
Author(s):  
Livio Pagano ◽  
Gabriella Pagliari ◽  
Agostino Basso ◽  
Roberto Marra ◽  
Simona Sica ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Microbiological Diagnosis ◽  
Haematological Malignancies

scholarly journals The Role of Cytogenetic Methods in the Diagnosis of Haematological Diseases

2021 ◽  
Author(s):  
Amina Aščerić ◽  
Mirela Mačkić Durović ◽  
Hilada Nefić
Keyword(s):  
Chromosomal Aberrations ◽  
Cytogenetic Analysis ◽  
Chromosomal Abnormalities ◽  
Haematological Malignancies ◽  
Diagnosis And Prognosis ◽  
Conventional Cytogenetic Analysis ◽  
Frequent Use ◽  
Conventional Cytogenetics ◽  
Cytogenetic Methods

Introduction: Conventional cytogenetics by the use of standard karyotyping allows the study of numerical and structural chromosomal aberrations. Haematological malignancies include a number of cancer types that originate in the blood cells of the bone marrow or of the lymphatic system. Cytogenetic methods are traditionally used for the sake of diagnosis and prognosis of these diseases. However, with the ever more frequent use of molecular methods in the diagnostic laboratories, the importance of the conventional cytogenetic analysis in the diagnosis of haematological diseases needs to be reassessed. Aim: To evaluate the role of cytogenetic methods in the diagnosis of haematological malignancies. Materials and Methods: A retrospective analysis of cytogenetic findings of 146 patients with various haematological malignancies was performed. All of the findings were made over a period of three years at the Centre for Genetics at the Medical Faculty of the University of Sarajevo in Bosnia and Herzegovina. Microsoft Excel 2019 was used for the analysis and presentation of data in the form of tables and graphs. Results: The results of the present study showed that the use of conventional cytogenetic analysis is a good diagnostic method for 50.68% (74) of patients in whom chromosomal aberrations were detected. Conclusion: Cytogenetics remains the most comprehensive method for assessing chromosomal abnormalities due to its ability to detect clinically relevant aneuploidies and additional cytogenetic abnormalities that cannot be detected by locus-specific assays.

scholarly journals Application of Genomics to Clinical Practice in Haematological Malignancy

2019 ◽  
Vol 7 (4) ◽  
pp. 236-252
Author(s):  
Coen Veenstra ◽  
David Bruce ◽  
Adele Timbs ◽  
Angela Hamblin
Keyword(s):  
Bone Marrow Aspirate ◽  
Residual Disease ◽  
Clinical Care ◽  
Lymphoid Tissues ◽  
Haematological Malignancies ◽  
Sequencing Technologies ◽  
Whole Exome ◽  
Disease Entities

Abstract Purpose of Review The usual abundance of fresh cells and high-quality DNA derived from bone marrow aspirate and peripheral blood mean haematological malignancies are at the forefront of the application of genomics to malignancy. This review evaluates where genomics is routinely used in clinical care and where opportunities for further application exist. Recent Findings The 2016 revision of the WHO classification of tumours of haematopoietic and lymphoid tissues increased the number of disease entities defined by, or whose diagnosis was strongly supported by, a specific genetic change. Increasingly combinations of mutations rather than individual lesions are being used to genomically classify heterogeneous disorders to inform prognosis and direct treatment. Furthermore, the role of different genetic aberrations as markers of measurable residual disease is being evaluated in clinical trials to allow intensification/de-intensification of treatment as appropriate and early detection of relapse. Summary Implementation of broader sequencing technologies such as whole exome/genome sequencing coupled with continuing developments in genomic technology to improve turn-around-times are likely to further reinforce the centrality of genomics in the management of haematological malignancies.

scholarly journals P45 Invasive fungal infections in haematological malignancies at a regional cancer institute – Role of panfungal PCR

2011 ◽  
Vol 9 (1) ◽  
pp. 18 ◽  
Author(s):  
S. Adurthi ◽  
T.P. Sahoo ◽  
M. Shafiulla ◽  
B. Radhika ◽  
L.A. Jacob ◽  
...  
Keyword(s):  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Haematological Malignancies ◽  
Panfungal Pcr
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