NUT Carcinoma Arising from the Parotid Gland: A Case Report and Review of the Literature

AbstractNUT carcinoma is an aggressive carcinoma with an overall poor survival outcome. The mediastinum and head and neck area, especially the sinonasal region, are among the common sites of disease. Histopathological diagnosis of NUT carcinoma is often very challenging due to its overlapping features with other poorly differentiated carcinomas. We report a case of NUT carcinoma arising from the parotid gland of a young female patient. Primary NUT carcinoma of salivary gland is very rare, with only 15 such cases reported in the literature to date. Our case highlights the diagnostic challenges associated with such lesions.

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Retroperitoneal Extragastrointestinal Stromal Tumors Have a Poor Survival Outcome: A Multicenter Observational Study

Cancer Management and Research ◽

10.2147/cmar.s278612 ◽

2020 ◽

Vol Volume 12 ◽

pp. 10491-10504

Author(s):

Weixian Hu ◽

Chengbin Zheng ◽

Renjie Li ◽

Xingyu Feng ◽

Guoliang Zheng ◽

...

Keyword(s):

Observational Study ◽

Survival Outcome ◽

Poor Survival ◽

Multicenter Observational Study ◽

Stromal Tumors ◽

Poor Survival Outcome

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GINS2 is Overexpressed in Esophageal Squamous Cell Cancer and Indicates Poor Survival Outcome

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2017.06.1098 ◽

2017 ◽

Vol 99 (2) ◽

pp. E207-E208

Author(s):

Y. Zhou ◽

X. Liu ◽

J. Li ◽

N. Liu ◽

Y. Dong ◽

...

Keyword(s):

Squamous Cell ◽

Squamous Cell Cancer ◽

Cell Cancer ◽

Survival Outcome ◽

Esophageal Squamous Cell Cancer ◽

Poor Survival ◽

Poor Survival Outcome

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LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer: Erratum

Theranostics ◽

10.7150/thno.68023 ◽

2021 ◽

Vol 11 (20) ◽

pp. 10171-10172

Author(s):

Biao Zheng ◽

Jianhua Qu ◽

Kenoki Ohuchida ◽

Haimin Feng ◽

Stephen Jun Fei Chong ◽

...

Keyword(s):

Pancreatic Cancer ◽

Liver Metastasis ◽

Survival Outcome ◽

Poor Survival ◽

Poor Survival Outcome ◽

High Liver

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Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC

10.21203/rs.2.23513/v1 ◽

2020 ◽

Author(s):

Toshiaki Iwase ◽

Kenichi Harano ◽

Hiroko Masuda ◽

Kumiko Kida ◽

Kenneth R. Hess ◽

...

Keyword(s):

Breast Cancer ◽

Gene Expression ◽

Inflammatory Breast Cancer ◽

Hormone Receptor ◽

Survival Outcome ◽

Stage Iii ◽

Prognostic Role ◽

Poor Survival ◽

Poor Survival Outcome

Abstract Purpose: The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.Methods: We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemical staining and determined the predictive and prognostic role of HR expression on 189 patients with HR+/HER2– IBC and 677 patients with HR+/HER2– stage III non-IBC. Furthermore, we performed gene expression (GE) analyses for 137 patients with HR+/HER2– IBC and 252 patients with corresponding non-IBC to detect genes that are specifically overexpressed in IBC.Results: The expression of ER% was significantly associated with longer distant disease-free survival and overall survival. However, there was no significant relationship between ER% and NAC outcome. In the GE study, 84 genes were identified as significantly distinguishing HR+ IBC from non-IBC. Among the top 15 canonical pathways expressed in IBC, the ERK/MAPK, PDGF, insulin receptor, and IL-7 signaling pathways were associated with the ER signaling pathway. Upregulation of the MYC gene was observed in three of these four pathways. Furthermore, HR+/HER2– IBC had significantly higher MYC amplification, and the genetic alteration was associated with poor survival outcome.Conclusions: Increased HR positivity was significantly associated with improved survival in both HR+/HER2– IBC and HR+/HER2– stage III non-IBC patients. HR+/HER2– IBC had several activated pathways with MYC upregulation, and the genetic alteration was associated with poor survival outcome. The results indicate that MYC may be a key gene for understanding the biology of HR+/HER2– IBC.

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